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YAP-Mediated Mechanotransduction in Skeletal Muscle

Abstract : Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and functionality is determined by its mechanical and physical environment. Processing intra-and extracellular mechanical signaling cues contributes to the regulation of cell growth, survival, migration and differentiation. Yes-associated Protein (YAP), a transcriptional coactivator downstream of the Hippo pathway and its paralog, the transcriptional co-activator with PDZ-binding motif (TAZ), were recently found to play a key role in mechanotransduction in various tissues including skeletal muscle. Furthermore, YAP/TAZ modulate myogenesis and muscle regeneration and abnormal YAP activity has been reported in muscular dystrophy and rhabdomyosarcoma. Here, we summarize the current knowledge of mechanosensing and-signaling in striated muscle. We highlight the role of YAP signaling and discuss the different routes and hypotheses of its regulation in the context of mechanotransduction.
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Martina Fischer, Paul Rikeit, Petra Knaus, Catherine Coirault. YAP-Mediated Mechanotransduction in Skeletal Muscle. Frontiers in Physiology, Frontiers, 2016, 7, ⟨10.3389/fphys.2016.00041⟩. ⟨inserm-02426450⟩



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