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Journal articles
Expression of fucosylated glycans in endothelial glycocalyces of placental villi at early and late fetal growth restriction
M.M. Ziganshina
1
G.V. Kulikova
1
N.M. Fayzullina
1
E.L. Yarotskaya
1
A.I. Shchegolev
1
Jacques Le Pendu
2
Adrien Breiman
2
N.V. Shilova
1, 3
N.R. Khasbiullina
1
N.V. Bovin
3
N.E. Kan
1
V.L. Tyutyunnik
1
Z.S. Khodzhaeva
1, 4
G.T. Sukhikh
1, 5
2
CRCINA - Département INCIT - Equipe 5 - Host-pathogen interactions in the regulation of immune responses
CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers
Z.S. Khodzhaeva 1, 4
Author
G.T. Sukhikh 1, 5
Author
1
National Medical Research Center for Obstetrics, Gynecology and Perinatology [Moscow, Russia] (Russia)
2
CRCINA - Département INCIT - Equipe 5 - Host-pathogen interactions in the regulation of immune responses (Département d'Immunologie et Nouveaux Concepts en Immunothérapie (INCIT).
CRCINA - Institut de Recherche en Santé de l'Université de Nantes - 8 quai Moncousu - BP 70721 - 44007 Nantes cedex 1. - France)
- CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers (8 quai de Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)
- UA - Université d'Angers (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1232 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : ERL6001 (France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
Abstract : The aim of the study was to investigate the content and distribution of fucosylated sugar residues and Lewis Y (LeY) in the endothelial glycocalyx (eGC) in placental tissue at early and late onset fetal growth restriction (FGR). Our findings demonstrated that the changes of the fucosylated glycans of type 2 (H2)/LeY in the vascular endothelium of the villi may reflect alteration of villi maturation, or adaptation to hypoxia through the change of cell proliferation potential and induction angiogenesis. Early onset FGR differs from late onset FGR by a markedly increased LeY expression, being associated with more severe pathological state.
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https://www.hal.inserm.fr/inserm-02426291
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, January 2, 2020 - 10:02:44 AM
Last modification on : Friday, January 3, 2020 - 1:25:24 AM
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, January 2, 2020 - 10:02:44 AM
Last modification on : Friday, January 3, 2020 - 1:25:24 AM
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Identifiers
- HAL Id : inserm-02426291, version 1
- DOI : 10.1016/j.placenta.2019.12.005
Collections
CRCNA | CRCINA | UNIV-NANTES | UNIV-ANGERS | CNRS
Citation
M.M. Ziganshina, G.V. Kulikova, N.M. Fayzullina, E.L. Yarotskaya, A.I. Shchegolev, et al.. Expression of fucosylated glycans in endothelial glycocalyces of placental villi at early and late fetal growth restriction. Placenta, Elsevier, 2019, 90, pp.98-102. ⟨10.1016/j.placenta.2019.12.005⟩. ⟨inserm-02426291⟩
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