A. Dhawan, J. Puppi, R. D. Hughes, and R. R. Mitry, Human hepatocyte transplantation: current experience and future challenges, Nat Rev Gastroenterol Hepatol, vol.7, issue.5, pp.288-298, 2010.

P. J. Bosma, N. R. Chowdhury, and B. G. Goldhoorn, Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I, Hepatology, vol.15, issue.5, pp.941-947, 1992.

I. J. Fox, J. R. Chowdhury, and S. S. Kaufman, Treatment of the Crigler-Najjar Syndrome Type I with Hepatocyte Transplantation, N Engl J Med, vol.338, issue.20, pp.1422-1427, 1998.

C. Guguen-guillouzo and A. Guillouzo, General review on in vitro hepatocyte models and their applications, Methods Mol Biol, vol.640, pp.1-40, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00742202

J. Yu, M. A. Vodyanik, and K. Smuga-otto, Induced pluripotent stem cell lines derived from human somatic cells, Science, vol.318, issue.5858, pp.1917-1920, 2007.

K. Takahashi, K. Tanabe, and M. Ohnuki, Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell, vol.131, issue.5, pp.861-872, 2007.

J. A. Thomson, J. Itskovitz-eldor, and S. S. Shapiro, Embryonic stem cell lines derived from human blastocysts, Science, vol.282, issue.5391, pp.1145-1147, 1998.

N. Dianat, C. Steichen, L. Vallier, A. Weber, and A. Dubart-kupperschmitt, Human pluripotent stem cells for modelling human liver diseases and cell therapy, Curr Gene Ther, vol.13, issue.2, pp.120-132, 2013.

S. Gerbal-chaloin, N. Funakoshi, A. Caillaud, C. Gondeau, B. Champon et al., Human induced pluripotent stem cells in hepatology: beyond the proof of concept, Am J Pathol, vol.184, issue.2, pp.332-347, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-00921587

K. Takayama, Y. Morisaki, and S. Kuno, Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes, Proc Natl Acad Sci, vol.111, issue.47, pp.16772-16777, 2014.

A. Carpentier, A. Tesfaye, and V. Chu, Engrafted human stem cellderived hepatocytes establish an infectious HCV murine model, J Clin Invest, vol.124, issue.11, pp.4953-4964, 2014.

M. Kajiwara, T. Aoi, and K. Okita, Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells, Proc Natl Acad Sci, vol.109, issue.31, pp.12538-12543, 2012.

H. Basma, A. Soto-gutiérrez, and G. R. Yannam, Differentiation and transplantation of human embryonic stem cell-derived hepatocytes, Gastroenterology, vol.136, issue.3, pp.990-999, 2009.

J. Cai, Y. Zhao, and Y. Liu, Directed differentiation of human embryonic stem cells into functional hepatic cells, Hepatology, vol.45, issue.5, pp.1229-1239, 2007.

D. C. Hay, J. Fletcher, and C. Payne, Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling, Proc Natl Acad Sci, vol.105, issue.34, pp.12301-12306, 2008.

K. Si-tayeb, F. K. Noto, and M. Nagaoka, Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells, Hepatology, vol.51, issue.1, pp.297-305, 2010.

G. J. Sullivan, D. C. Hay, and I. H. Park, Generation of functional human hepatic endoderm from human induced pluripotent stem cells, Hepatology, vol.51, issue.1, pp.329-335, 2010.

D. Hanahan and J. Folkman, Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis, Cell, vol.86, pp.353-364, 1996.

C. Du, Y. Feng, and D. Qiu, Highly efficient and expedited hepatic differentiation from human pluripotent stem cells by pure smallmolecule cocktails, Stem Cell Res Ther, vol.9, issue.1, p.58, 2018.

S. Asgari, M. Moslem, K. Bagheri-lankarani, B. Pournasr, M. Miryounesi et al., Differentiation and transplantation of human induced pluripotent stem cell-derived hepatocyte-like cells, Stem Cell Rev, vol.9, issue.4, pp.493-504, 2013.

C. Lyu, J. Shen, and R. Wang, Targeted genome engineering in human induced pluripotent stem cells from patients with hemophilia B using the CRISPR-Cas9 system, Stem Cell Res Ther, vol.9, issue.1, p.92, 2018.

L. Tolosa, J. Caron, and Z. Hannoun, Transplantation of hESC-derived hepatocytes protects mice from liver injury, Stem Cell Res Ther, vol.6, issue.1, p.246, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-01254139

K. G. Chen, B. S. Mallon, R. Mckay, and P. G. Robey, Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics, Cell Stem Cell, vol.14, issue.1, pp.13-26, 2014.

Z. Polgar, Y. Li, L. Wang, X. Guha, C. Roy-chowdhury et al., Gunn rats as a surrogate model for evaluation of hepatocyte transplantation-based therapies of crigler-najjar syndrome type 1, Methods Mol Biol, vol.1506, pp.131-147, 2017.

L. Tolosa, S. López, and E. Pareja, Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat, Liver Transplant, vol.21, issue.6, pp.801-811, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02147047

C. Maerckx, T. Tondreau, S. Berardis, J. Van-pelt, M. Najimi et al., Human liver stem/progenitor cells decrease serum bilirubin in hyperbilirubinemic Gunn rat, World J Gastroenterol, vol.20, issue.30, pp.10553-10563, 2014.

Y. Chen, Y. Li, and X. Wang, Amelioration of hyperbilirubinemia in gunn rats after transplantation of human induced pluripotent stem cell-derived hepatocytes, Stem Cell Reports, vol.5, issue.1, pp.22-30, 2015.

L. Spitzhorn, C. Kordes, and M. Megges, Transplanted human pluripotent stem cell-derived mesenchymal stem cells support liver regeneration in Gunn rats, Stem Cells Dev, vol.27, issue.24, pp.1702-1714, 2018.

S. Pauklin and L. Vallier, The cell cycle state of stem cells determines cell fate propensity, Cell, vol.155, issue.1, pp.135-147, 2013.

R. L. Gieseck, . Iii, N. Hannan, and R. Bort, Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture, PLoS ONE, vol.9, issue.1, p.86372, 2014.

T. H. Nguyen, J. Oberholzer, J. Birraux, P. Majno, P. Morel et al., Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes, Mol Ther, vol.6, issue.2, pp.199-209, 2002.

T. H. Nguyen, A. D. Bellodi-privato, and M. , Critical assessment of lifelong phenotype correction in hyperbilirubinemic Gunn rats after retroviral mediated gene transfer, Gene Ther, vol.14, issue.17, pp.1270-1277, 2007.

M. Black, B. H. Billing, and K. Heirwegh, Determination of bilirubin UDPglucuronyl transferase activity in needle-biopsy specimens of human liver, Clin Chim Acta, vol.29, issue.1, pp.27-35, 1970.

S. Ménoret, L. H. Ouisse, and L. Tesson, Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models, Transplantation, vol.102, issue.8, pp.1271-1278, 2018.

K. Takayama, Y. Nagamoto, and N. Mimura, Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes, Stem Cell Reports, vol.1, issue.4, pp.332-335, 2013.

N. Hannan, C. Segeritz, T. Touboul, and L. Vallier, Production of hepatocyte-like cells from human pluripotent stem cells, Nat Protoc, vol.8, issue.2, pp.430-437, 2013.

P. Ekblom, P. Lonai, and J. F. Talts, Expression and biological role of laminin-1, Matrix Biol, vol.22, issue.1, pp.35-47, 2003.

G. Lanzoni, T. Oikawa, and Y. Wang, Concise review: clinical programs of stem cell therapies for liver and pancreas, Stem Cells, vol.31, issue.10, pp.2047-2060, 2013.

K. Cameron, R. Tan, and W. Schmidt-heck, Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes, Stem Cell Reports, vol.5, issue.6, pp.1250-1262, 2015.

H. Ikebukuro, M. Inagaki, M. Mito, S. Kasai, K. Ogawa et al., Prolonged function of hepatocytes transplanted into the spleens of Nagase analbuminemic rats, Eur Surg Res, vol.31, issue.1, pp.39-47, 1999.

K. Takayama, N. Akita, and N. Mimura, Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine, Hepatol Commun, vol.1, issue.10, pp.1058-1069, 2017.

S. Blackford, S. S. Ng, and J. M. Segal, Validation of current good manufacturing practice compliant human pluripotent stem cellderived hepatocytes for cell-based therapy, Stem Cells Transl. Med, vol.8, issue.2, pp.124-137, 2019.

I. Dagher, T. H. Nguyen, and M. Groyer-picard, Efficient hepatocyte engraftment and long-term transgene expression after reversible portal embolization in nonhuman primates, Hepatology, vol.49, issue.3, pp.950-959, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00326130

K. Yamanouchi, H. Zhou, and N. Roy-chowdhury, Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation, Hepatology, vol.49, issue.1, pp.258-267, 2009.

G. G. Gornalusse, R. K. Hirata, and S. E. Funk, HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells, Nat Biotechnol, vol.35, issue.8, pp.765-772, 2017.