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Performance of Day 5 KIDScore™ morphokinetic prediction models of implantation and live birth after single blastocyst transfer

Abstract : PURPOSE : While several studies reported the association between morphokinetic parameters and implantation, few predictive models were developed to predict implantation after day 5 embryo transfer, generally without external validation. The objective of this study was to evaluate the respective performance of 2 commercially available morphokinetic-based models (KIDScore™ Day 5 versions 1 and 2) for the prediction of implantation and live birth after day 5 single blastocyst transfer. METHODS : This monocentric retrospective study was conducted on 210 ICSI cycles with single day 5 embryo transfer performed with a time-lapse imaging (TLI) system between 2013 and 2016. The association between both KIDScore™ and the observed implantation and live birth rates was calculated, as well as the agreement between embryologist's choice for transfer and embryo ranking by the models. RESULTS : Implantation and live birth rate were both 35.7%. A significant positive correlation was found between both models and implantation rate (r = 0.96 and r = 0.90, p = 0.01) respectively. Both models had statistically significant but limited predictive power for implantation (AUC 0.60). There was a fair agreement between the embryologists' choice and both models (78% and 61% respectively), with minor differences in case of discrepancies. CONCLUSIONS : KIDScore™ Day 5 predictive models are significantly associated with implantation rates after day 5 single blastocyst transfer. However, their predictive performance remains perfectible. The use of these predictive models holds promises as decision-making tools to help the embryologist select the best embryo, ultimately facilitating the implementation of SET policy. However, embryologists' expertise remains absolutely necessary to make the final decision.
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https://www.hal.inserm.fr/inserm-02420079
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Thursday, December 19, 2019 - 4:55:37 PM
Last modification on : Saturday, December 21, 2019 - 1:29:47 AM

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Arnaud Reignier, Jean-Maxime Girard, Jenna Lammers, Sana Chtourou, Tiphaine Lefebvre, et al.. Performance of Day 5 KIDScore™ morphokinetic prediction models of implantation and live birth after single blastocyst transfer. Journal of Assisted Reproduction and Genetics, Springer Verlag, 2019, 36 (11), pp.2279-2285. ⟨10.1007/s10815-019-01567-x⟩. ⟨inserm-02420079⟩

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