Picornavirus and enterovirus diversity with associated human diseases, Infect., Genet. Evol, vol.14, pp.282-93, 2013. ,
Direct-acting antivirals and host-targeting strategies to combat enterovirus infections, Curr. Opin. Virol, vol.24, pp.1-8, 2017. ,
Poliovirus protein 2C has ATPase and GTPase activities, J. Biol. Chem, vol.268, issue.11, pp.8105-8110, 1993. ,
Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication, J. Biol. Chem, vol.274, issue.11, pp.6992-7001, 1999. ,
, , p.9, 1999.
, strain barty non-structural protein 2C has NTPase activity, Virus Res, vol.65, issue.2, pp.155-60
Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone, PLoS Pathog, vol.11, issue.7, p.1005067, 2015. ,
Structure and mechanism of helicases and nucleic acid translocases, Annu. Rev. Biochem, vol.76, pp.23-50, 2007. ,
An intragenic revertant of a poliovirus 2C mutant has an uncoating defect, J. Virol, vol.64, issue.3, pp.1102-1107, 1990. ,
Membrane rearrangement and vesicle induction by recombinant poliovirus 2C and 2BC in human cells, Virology, vol.202, issue.1, pp.129-174, 1994. ,
Induction of membrane proliferation by poliovirus proteins 2C and 2BC, Biochem. Biophys. Res. Commun, vol.206, issue.1, pp.64-76, 1995. ,
Poliovirus 2C protein determinants of membrane binding and rearrangements in mammalian cells, J. Virol, vol.71, issue.12, pp.8962-8972, 1997. ,
Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles, J. Virol, vol.74, issue.19, pp.8953-65, 2000. ,
Poliovirusencoded 2C polypeptide specifically binds to the 3?-terminal sequences of viral negative-strand RNA, J. Virol, vol.71, issue.12, pp.9570-9578, 1997. ,
Interaction of picornavirus 2C polypeptide with the viral negative-strand RNA, J. Gen. Virol, vol.82, issue.11, pp.2621-2627, 2001. ,
Interaction of poliovirus-encoded 2C/2BC polypeptides with the 3? terminus negative-strand cloverleaf requires an intact stem-loop b, Virology, vol.280, issue.1, pp.41-51, 2001. ,
Isolation of poliovirus 2C mutants defective in viral RNA synthesis, J. Virol, vol.62, issue.11, pp.4016-4021, 1988. ,
Analysis of the functional significance of amino acid residues in the putative NTP-binding pattern of the poliovirus 2C protein, J. Gen. Virol, vol.73, issue.8, 1977. ,
Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization, J. Mol. Biol, vol.236, issue.5, pp.1310-1333, 1994. ,
Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C, J. Virol, vol.71, issue.11, pp.8482-8489, 1997. ,
Evidence for functional protein interactions required for poliovirus RNA replication, J. Virol, vol.80, issue.11, pp.5327-5364, 2006. ,
Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication, J. Biol. Chem, vol.282, issue.8, pp.5888-98, 2007. ,
Enterovirus 71 2C protein inhibits TNF-alpha-mediated activation of NF-kappaB by suppressing IkappaB kinase beta phosphorylation, J. Immunol, vol.187, issue.5, pp.2202-2214, 2011. ,
, , 1997.
, Poliovirus 2C region functions during encapsidation of viral RNA, J. Virol, vol.71, issue.11, pp.8759-8765
The antiviral compound 5-(3,4-dichlorophenyl) methylhydantoin inhibits the post-synthetic cleavages and the assembly of poliovirus in a cell-free system, Antiviral Res, vol.48, issue.1, pp.61-70, 2000. ,
Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis, PLoS Pathog, vol.6, issue.8, p.1001066, 2010. ,
A C-terminal, cysteine-rich site in poliovirus 2C(ATPase) is required for morphogenesis, Replication and Inhibitors of Enteroviruses and Parechoviruses. Viruses, vol.95, pp.4529-4562, 2014. ,
Dependence of echovirus 9 on the enterovirus RNA replication inhibitor 2-(alpha-Hydroxybenzyl)-benzimidazole maps to nonstructural protein 2C, J. Virol, vol.73, issue.12, pp.10536-10539, 1999. ,
The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C, J. Virol, vol.82, issue.10, pp.4720-4750, 2008. ,
Mutations in the 2C region of poliovirus responsible for altered sensitivity to benzimidazole derivatives, J. Virol, vol.74, issue.9, pp.4146-54, 2000. ,
Drug repositioning: identifying and developing new uses for existing drugs, Nat. Rev. Drug Discovery, vol.3, issue.8, pp.673-83, 2004. ,
Drug Repurposing for Viral Infectious Diseases: How Far Are We?, Trends Microbiol, vol.26, issue.10, pp.865-876, 2018. ,
Fluoxetine Is a Potent Inhibitor of Coxsackievirus Replication, Antimicrob. Agents Chemother, vol.56, issue.9, pp.4838-4844, 2012. ,
Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C, Antimicrob. Agents Chemother, vol.57, issue.4, pp.1952-1958, 2013. ,
Screening of a library of FDA-approved drugs identifies several enterovirus replicaton inhibitors that target viral protein 2C, Antimicrob. Agents Chemother, vol.60, p.2627, 2016. ,
Fluoxetine a novel anti-hepatitis C virus agent via ROS-, JNK-, and PPARbeta/gamma-dependent pathways, Antiviral Res, vol.110, pp.158-67, 2014. ,
N-Desmethylclozapine, Fluoxetine, and Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle, Antimicrob. Agents Chemother, vol.60, issue.11, pp.6709-6718, 2016. ,
Treatment of Chronic Enterovirus Encephalitis With Fluoxetine in a Patient With X-Linked Agammaglobulinemia, Pediatr Neurol, vol.64, p.94, 2016. ,
Crystal structure of 2C helicase from enterovirus 71, Sci. Adv, vol.3, issue.4, p.1602573, 2017. ,
Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor, J. Med. Chem, vol.31, issue.1, pp.185-194, 1988. ,
Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses, Antimicrob. Agents Chemother, vol.60, issue.3, pp.1615-1641, 2016. ,
Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus, Cell. Microbiol, vol.17, p.1144, 2015. ,
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein, Cell Rep, vol.10, issue.4, pp.600-615, 2015. ,
Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery, Antiviral Res, vol.106, pp.61-70, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02061701
Poliovirus 2C protein forms homo-oligomeric structures required for ATPase activity, J. Biol. Chem, vol.284, issue.33, pp.22012-22033, 2009. ,
Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism, J. Biol. Chem, vol.285, issue.32, pp.24347-59, 2010. ,
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIbeta, Antimicrob. Agents Chemother, vol.57, issue.10, pp.4971-81, 2013. ,
Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections, ACS Med. Chem. Lett, vol.4, issue.7, pp.585-594, 2013. ,
A novel class of highly potent small molecule inhibitors of entero/rhinovirus replication that target the non structural protein 2C, 2013. ,
Global emergence of enterovirus D68: a systematic review, Lancet Infect. Dis, vol.16, issue.5, pp.64-75, 2016. ,
Evaluating Treatment Efficacy in a Mouse Model of Enterovirus D68-Associated Paralytic Myelitis, J. Infect. Dis, vol.216, issue.10, pp.1245-1253, 2017. ,
, ACS Infectious Diseases
Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis, Neurology, vol.92, issue.18, pp.2118-2126, 2019. ,
Fluoxetine can inhibit coxsackievirus-B4 E2 in vitro and in vivo, Antiviral Res, vol.159, pp.130-133, 2018. ,
Fluoxetine and norfluoxetine plasma concentrations in major depression: a multicenter study, Am. J. Psychiatry, vol.154, issue.7, pp.963-969, 1997. ,
Role of annexin A2 in the production of infectious hepatitis C virus particles, J. Virol, vol.84, issue.11, pp.5775-89, 2010. ,
,
, GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication, J. Virol, vol.83, issue.22, pp.11940-11949
Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment, Am. J. Epidemiol, vol.80, issue.23, pp.493-497, 1938. ,
, , vol.12, 2012.
MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry, J. Comput.-Aided Mol. Des, vol.9, issue.3, pp.251-68, 1995. ,
The generalized Born/volume integral implicit solvent model: estimation of the free energy of hydration using London dispersion instead of atomic surface area, J. Comput. Chem, vol.29, issue.10, pp.1693-1701, 2008. ,
Structure validation by Calpha geometry: phi,psi and Cbeta deviation, Proteins: Struct., Funct., Genet, vol.50, pp.437-450, 2003. ,
A method to identify protein sequences that fold into a known three-dimensional structure, Science, vol.253, issue.5016, pp.164-70, 1991. ,
Assessment of protein models with three-dimensional profiles, Nature, vol.356, issue.6364, pp.83-88, 1992. ,
Verification of protein structures: patterns of nonbonded atomic interactions, Protein Sci, vol.2, issue.9, pp.1511-1520, 1993. ,
Deviations from standard atomic volumes as a quality measure for protein crystal structures, J. Mol. Biol, vol.264, issue.1, pp.121-157, 1996. ,
, ACS Infectious Diseases Article DOI: 10.1021/acsinfecdis.9b00179 ACS Infect. Dis, vol.5, pp.1609-1623, 2019.