C. Curtis, S. P. Shah, S. F. Chin, G. Turashvili, O. M. Rueda et al., The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups, Nature, vol.486, issue.7403, pp.346-52, 2012.

D. J. Slamon, G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich et al., Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene, Science, vol.235, issue.4785, pp.177-82, 1987.

P. Carter, L. Presta, C. M. Gorman, J. B. Ridgway, D. Henner et al., Humanization of an anti-p185HER2 antibody for human cancer therapy, Proceedings of the National Academy of Sciences of the United States of America, vol.89, issue.10, pp.4285-4294, 1992.

Q. Ryan, A. Ibrahim, M. H. Cohen, J. Johnson, C. W. Ko et al., FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2. The oncologist, vol.13, pp.1114-1123, 2008.

I. E. Krop, S. B. Kim, A. G. Martin, P. M. Lorusso, J. M. Ferrero et al., Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial, Lancet Oncol, 2017.

Y. Xie and M. C. Hung, Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation, Biochem Biophys Res Commun, vol.203, issue.3, pp.1589-98, 1994.

D. K. Giri, M. Ali-seyed, L. Y. Li, D. F. Lee, P. Ling et al., Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor, Molecular and cellular biology, vol.25, issue.24, pp.11005-11023, 2005.

W. Beguelin, M. C. Diaz-flaque, C. J. Proietti, F. Cayrol, M. A. Rivas et al., Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3, Molecular and cellular biology, vol.30, issue.23, pp.5456-72, 2010.

M. C. Diaz-flaque, N. M. Galigniana, W. Beguelin, R. Vicario, C. J. Proietti et al., Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy, Breast Cancer Res, vol.15, issue.6, 2013.

M. C. Diaz-flaque, R. Vicario, C. J. Proietti, F. Izzo, R. Schillaci et al., Progestin drives breast cancer growth by inducing p21(CIP1) expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2, Steroids, vol.78, issue.6, pp.559-67, 2013.

S. C. Wang, H. C. Lien, W. Xia, I. F. Chen, H. W. Lo et al., Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2, Cancer cell, vol.6, issue.3, pp.251-61, 2004.

L. Venturutti, L. V. Romero, A. J. Urtreger, M. F. Chervo, C. Russo et al., Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis, Oncogene, vol.35, issue.17, pp.2208-2230, 2016.

L. Y. Li, H. Chen, Y. H. Hsieh, Y. N. Wang, H. J. Chu et al., Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes, Cancer Res, vol.71, issue.12, pp.4269-79, 2011.

X. Li, J. Kuang, Y. Shen, M. M. Majer, C. C. Nelson et al., The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells, The Journal of biological chemistry, vol.287, issue.27, pp.23171-83, 2012.

M. F. Dillon, A. T. Stafford, G. Kelly, A. M. Redmond, M. Mcilroy et al., Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. Endocrine-related cancer, Epub 2008/05/13, vol.15, pp.745-53, 2008.

R. Schillaci, P. Guzman, F. Cayrol, W. Beguelin, M. C. Diaz-flaque et al., Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer, BMC cancer, vol.12, 2012.

C. Russo, R. I. Beguelin, W. Diaz-flaque, M. C. Proietti, C. J. Venturutti et al., Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance, Oncogene, vol.34, issue.26, pp.3413-3441, 2015.

A. A. Serandour, G. D. Brown, J. D. Cohen, and J. S. Carroll, Development of an Illumina-based ChIP-exonuclease method provides insight into FoxA1-DNA binding properties, Genome biology, vol.14, issue.12, 2013.

Y. Zhang, T. Liu, C. A. Meyer, J. Eeckhoute, D. S. Johnson et al., Model-based analysis of ChIP-Seq (MACS), vol.9, 2008.

N. D. Heintzman, R. K. Stuart, G. Hon, Y. Fu, C. W. Ching et al., Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome, Nat Genet, vol.39, issue.3, pp.311-319, 2007.

C. Poulard, J. Rambaud, L. Romancer, M. Corbo, and L. , Proximity ligation assay to detect and localize the interactions of ERalpha with PI3-K and Src in breast cancer cells and tumor samples, Methods Mol Biol, vol.1204, pp.135-178, 2014.

V. K. Mootha, C. M. Lindgren, K. F. Eriksson, A. Subramanian, S. Sihag et al., PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes, Nature genetics, vol.34, issue.3, pp.267-73, 2003.

A. Subramanian, P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert et al., Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc Natl Acad Sci U S A, vol.102, issue.43, pp.15545-50, 2005.

H. Mohammed, C. Santos, A. A. Serandour, H. R. Ali, G. D. Brown et al., Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor, Cell Rep, vol.3, issue.2, pp.342-351, 2013.

S. Y. Lin, K. Makino, W. Xia, A. Matin, Y. Wen et al., Nuclear localization of EGF receptor and its potential new role as a transcription factor, Nature cell biology, vol.3, issue.9, 2001.

L. Andrique, D. Fauvin, E. Maassarani, M. Colasson, H. Vannier et al., ErbB3(80 kDa), a nuclear variant of the ErbB3 receptor, binds to the Cyclin D1 promoter to activate cell proliferation but is negatively controlled by p14ARF, Cellular signalling, vol.24, issue.5, 2012.

Y. N. Wang, H. H. Lee, H. J. Lee, Y. Du, H. Yamaguchi et al., Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. The Journal of biological chemistry, vol.287, pp.16869-79, 2012.

M. A. Dawson, A. J. Bannister, B. Gottgens, S. D. Foster, T. Bartke et al., JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin, Nature, vol.461, issue.7265, pp.819-841, 2009.

V. K. Tiwari, M. B. Stadler, C. Wirbelauer, R. Paro, D. Schubeler et al., A chromatin-modifying function of JNK during stem cell differentiation, Nat Genet, vol.44, issue.1, pp.94-100, 2012.

D. Schmidt, M. D. Wilson, C. Spyrou, G. D. Brown, J. Hadfield et al., ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions, Methods, vol.48, issue.3, pp.240-248, 2009.

B. Langmead and S. L. Salzberg, Fast gapped-read alignment with Bowtie 2, Nat Methods, vol.9, issue.4, pp.357-366, 2012.

C. Zang, D. E. Schones, C. Zeng, K. Cui, K. Zhao et al., A clustering approach for identification of enriched domains from histone modification ChIP-Seq data, Bioinformatics, vol.25, issue.15, pp.1952-1960, 2009.

E. P. Consortium, An integrated encyclopedia of DNA elements in the human genome, Nature, vol.489, issue.7414, pp.57-74, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-02187850

T. L. Bailey, M. Boden, F. A. Buske, M. Frith, C. E. Grant et al., SUITE: tools for motif discovery and searching, Nucleic Acids Res, vol.37, pp.202-210, 2009.

C. Trapnell, L. Pachter, and S. L. Salzberg, TopHat: discovering splice junctions with RNA-Seq, Bioinformatics, vol.25, issue.9, pp.1105-1116, 2009.

M. I. Love, W. Huber, and S. Anders, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome biology, vol.15, issue.12, p.25516281, 2014.