Type 2 diabetes mellitus, pandemic in 21st century, Adv Exp Med Biol, vol.771, pp.42-50, 2012. ,
The origins and drivers of insulin resistance, Cell, vol.152, pp.673-84, 2013. ,
Insulin resistance, small LDL particles, and risk for atherosclerotic disease, Curr Vasc Pharmacol, vol.12, pp.653-660, 2014. ,
Celastrol: Molecular targets of thunder god vine, Biochem Biophys Res Commun, vol.394, pp.439-481, 2010. ,
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease, Prog Neuropsychopharmacol Biol Psychiatry, vol.25, pp.1341-57, 2001. ,
Molecular targets of celastrol derived from thunder of god vine: Potential role in the treatment of inflammatory disorders and cancer, Cancer Lett, vol.303, pp.9-20, 2011. ,
HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way, Mol Cancer, vol.9, p.79, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00668221
Suppression of autoimmune arthritis by celastrus-derived celastrol through modulation of proinflammatory chemokines, Bioorg Med Chem, vol.20, pp.5229-5263, 2012. ,
Tripterine inhibits the expression of adhesion molecules in activated endothelial cells, J Leukoc Biol, vol.80, pp.309-328, 2006. ,
URL : https://hal.archives-ouvertes.fr/inserm-00180304
Celastrol attenuates hypertensioninduced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1, Am J Hypertens, vol.23, pp.895-903, 2010. ,
Celastrol, an NF-?B inhibitor, improves insulin resistance and attenuates renal injury in db/db mice, PLoS ONE, vol.8, p.62068, 2013. ,
Regulation of glucose transporter translocation in health and diabetes, Annu Rev Biochem, vol.81, pp.507-539, 2012. ,
Saturated fatty acidinduced insulin resistance in rat adipocytes, Diabetes, vol.43, pp.540-545, 1994. ,
Genistein reverses free fatty acid-induced insulin resistance in HepG2 hepatocytes through targeting JNK, J Huazhong Univ Sci Technol Med Sci, vol.31, pp.185-194, 2011. ,
MicroRNAs in ?-cell biology, insulin resistance, diabetes and its complications, Diabetes, vol.60, pp.1825-1856, 2011. ,
MicroRNAs in insulin resistance and obesity, Exp Diabetes Res, vol.2012, p.484696, 2012. ,
miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma, Oral Dis, vol.19, pp.611-620, 2013. ,
MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes, Biochem Biophys Res Commun, vol.389, pp.315-335, 2009. ,
IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: Role of microRNA-1 and microRNA-133a, J Cell Mol Med, vol.16, pp.83-95, 2012. ,
The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational repression of IRS-1 in SK-Hep1 cells, Biochem Biophys Res Commun, vol.434, pp.503-511, 2013. ,
Mechanism of growth inhibition by MicroRNA 145: The role of the IGF-I receptor signaling pathway, J Cell Physiol, vol.220, pp.485-91, 2009. ,
MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism, Cardiovasc Res, vol.86, pp.410-430, 2010. ,
Liposomal delivery of microRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitorresistance in lung cancer cells, Mol Cancer Ther, vol.10, pp.1720-1727, 2011. ,
MicroRNAs overexpressed in growth-restricted rat skeletal muscles regulate the glucose transport in cell culture targeting central TGF-? factor SMAD4, PLoS ONE, vol.7, p.34596, 2012. ,
The cell growth suppressor, mir-126, targets IRS-1, Biochem Biophys Res Commun, vol.377, pp.136-176, 2008. ,
Free fatty acidinduced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1, Endocrinology, vol.142, pp.229-269, 2001. ,
The functions of animal microRNAs, Nature, vol.431, pp.350-355, 2004. ,
MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2, Mol Cell Endocrinol, vol.381, pp.230-270, 2013. ,
Regulation of glucose transport by insulin: Traffic control of GLUT4, Nat Rev Mol Cell Biol, vol.13, pp.383-96, 2012. ,
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2, Diabetologia, vol.55, pp.2565-82, 2012. ,
Epigenetics: The missing link to understanding ?-cell dysfunction in the pathogenesis of type 2 diabetes, Epigenetics, vol.7, pp.841-52, 2012. ,
MicroRNAs in metabolism and metabolic disorders, Nat Rev Mol Cell Biol, vol.13, pp.239-50, 2012. ,
Role of microRNAs in diabetes and its cardiovascular complications, Cardiovasc Res, vol.93, pp.583-93, 2012. ,
miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells, Cell Physiol Biochem, vol.32, pp.448-58, 2013. ,
Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-?B activity, Cancer Cell Int, vol.13, p.50, 2013. ,
Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells, Carcinogenesis, vol.33, pp.886-94, 2012. ,
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-?B and STAT3 regulated gene products in multiple myeloma cells, Br J Pharmacol, vol.164, pp.1506-1527, 2011. ,
Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid, Biochem Pharmacol, vol.72, pp.1311-1332, 2006. ,
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators, Cancer Cell, vol.10, pp.321-351, 2006. ,
Inhibitory action of celastrol on hypoxiamediated angiogenesis and metastasis via the HIF-1? pathway, Int J Mol Med, vol.27, pp.407-422, 2011. ,
Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor ?, Cancer Lett, vol.300, pp.57-65, 2011. ,
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor, J Mol Med, vol.88, pp.1243-53, 2010. ,