Predicting RTS,S vaccine-mediated protection from transcriptomes in a malaria-challenge clinical trial. Front Immunol, vol.8, p.557, 2017. ,
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans, Proc Natl Acad Sci, vol.114, pp.2425-2430, 2017. ,
Different adjuvants induce common innate pathways that are associated with enhanced adaptive responses against a model antigen in humans, Front Immunol, vol.8, p.943, 2017. ,
Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells, J. Immunol, vol.193, pp.1920-1930, 2014. ,
AS04, an aluminum salt-and TLR4 agonistbased adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity, J. Immunol, vol.183, pp.6186-6197, 2009. ,
Adjuvant System AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity, vol.29, pp.2461-2473, 2011. ,
The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells, J. Immunol, vol.180, pp.5402-5412, 2008. ,
, The Authors, European Journal of Immunology, 2019.
Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates, Blood, vol.119, pp.2044-2055, 2012. ,
Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake, Sci. Transl. Med, vol.9, 2017. ,
ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells, J. Immunol, vol.187, pp.55-63, 2011. ,
Sensing infection and tissue damage, EMBO Mol. Med, vol.9, pp.285-288, 2017. ,
Analysis of the innate response to adjuvants: characterization of the draining lymph node by fluorescence-activated cell sorting, Methods Mol. Biol, vol.1494, pp.305-312, 2017. ,
Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNgamma response promoting vaccine immunogenicity, NPJ Vaccines, vol.2, p.25, 2017. ,
Lysosome-dependent activation of human dendritic cells by the vaccine adjuvant QS-21, Front. Immunol, vol.7, p.663, 2016. ,
Toll-like receptors differentially regulate CC and CXC chemokines in skeletal muscle via NF-kappaB and calcineurin, Infect. Immun, vol.74, pp.6829-6838, 2006. ,
Adjuvant system AS01: helping to overcome the challenges of modern vaccines, Expert Rev. Vaccines, vol.16, pp.55-63, 2017. ,
Central role of CD169 + lymph node resident macrophages in the adjuvanticity of the QS-21 component of AS01, Sci. Rep, vol.6, p.39475, 2016. ,
Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans, vol.37, pp.2004-2015, 2019. ,
Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production, J. Leukoc Biol. 2017, vol.102, pp.57-69 ,
Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant, PLoS One, vol.6, p.16333, 2011. ,
Comparative transcriptome profiles of human blood in response to the toll-like receptor 4 ligands lipopolysaccharide and monophosphoryl lipid A, p.40050 ,
Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function, Nat. Immunol, vol.6, pp.163-170, 2005. ,
Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi, Cell Host Microbe, vol.7, pp.474-487, 2010. ,
Essential yet limited role for CCR2(+) inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming, p.1086, 2013. ,
Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10, Clin. Exp. Immunol, vol.145, pp.535-544, 2006. ,
IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells, J. Leukoc Biol, vol.71, pp.669-676, 2002. ,
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells, Immunity, vol.37, pp.1076-1090, 2012. ,
Programming the magnitude and persistence of antibody responses with innate immunity, Nature, vol.470, pp.543-547, 2011. ,
Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice, vol.30, pp.3126-3135, 2012. ,
Effect of lipopolysaccharide on inflammation and insulin action in human muscle, PLoS One, vol.8, p.63983, 2013. ,
Endothelial cell tolerance to lipopolysaccharide challenge is induced by monophosphoryl lipid A, Clin. Sci, vol.130, pp.451-461, 2016. ,
House dust mite allergen induces asthma via Tolllike receptor 4 triggering of airway structural cells, Nat. Med, vol.15, pp.410-416, 2009. ,
Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin, J. Immunol, vol.175, pp.6861-6869, 2005. ,
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity, Mucosal Immunol, vol.7, pp.489-500, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-00925663
Guidelines for the use of flow cytometry and cell sorting in immunological studies, Eur. J. Immunol, vol.47, pp.1584-1797, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01619848
, Belgium e-mail: arnaud.x.didierlaurent@gsk.com The peer review history for this article is, Abbreviations: AS: Adjuvant System · DC: dendritic cell · dLN: draining lymph node · HBs: Hepatitis B surface antigen · ILLN: draining iliac lymph node · MPL: 3-O-desacyl-4'-monophosphoryl lipid A Full correspondence: Dr. Arnaud Didierlaurent, GSK