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Master Role of Glucose-6 Phosphate in Cell Signalling and Consequences of its Deregulation in the Liver and Kidneys: Key metabolic role of glucose-6 phosphate

Gilles Mithieux 1, * Fabienne Rajas 1
* Corresponding author
Abstract : Maintaining blood glucose levels through periods of fasting or excess of nutrients is a crucial function to the survival of the organism. In this review, we describe the glucose metabolism during the fed-to-fasted transition and in two metabolic diseases characterized by either an overproduction of glucose and hyperglycemia, that is, type 2 diabetes, or by a deficiency of glucose production and hypoglycemia, that is, glycogen storage disease type I. In these two pathologies, glucose-6 phosphate plays a master role in cell signaling. Indeed, the increased flux downstream of glucose-6 phosphate leads to a complete metabolism reprograming and an accumulation of lipids in the liver and kidneys. Thus, with time, type 2 diabetic patients and GSDI patients can develop hepatic tumors and chronic kidney disease.
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Submitted on : Thursday, November 28, 2019 - 10:17:49 AM
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Gilles Mithieux, Fabienne Rajas. Master Role of Glucose-6 Phosphate in Cell Signalling and Consequences of its Deregulation in the Liver and Kidneys: Key metabolic role of glucose-6 phosphate. Vinood Patel. Molecular Nutrition: Carbohydrates, Chapter 10, Elsevier, pp.173-189, 2019, 9780128498866. ⟨10.1016/B978-0-12-849886-6.00021-5⟩. ⟨inserm-02383971⟩

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