Jonker (pcDNA3.1/Hnf4?), H. Towle (minimal promoter PGL3/ChREBP luciferase reporter), and J. Chiang (human and mouse PGL3/ Cyp8b1 promoter luciferase reporters). We thank A. Herling and D. Schmoll (Sanofi) for providing S4048 and L. Chan for sharing the ChREBP ChIPseq data set ,
Role of bile acids and bile acid receptors in metabolic regulation, Physiol Rev, vol.89, pp.147-191, 2009. ,
Human insulin resistance is associated with increased plasma levels of 12?-hydroxylated bile acids, Diabetes, vol.62, pp.4184-4191, 2013. ,
Effects of diabetes mellitus on cholesterol metabolism in man, N Engl J Med, vol.296, pp.1365-1371, 1977. ,
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia, Cell Metab, vol.15, pp.65-74, 2012. ,
Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism, Hepatology, vol.52, pp.1455-1464, 2010. ,
Bile acids: regulation of synthesis, J Lipid Res, vol.50, pp.1955-1966, 2009. ,
Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis, Gastroenterology, vol.129, pp.1445-1453, 2005. ,
Insulin regulation of cholesterol 7?-hydroxylase expression in human hepatocytes, J Biol Chem, vol.281, pp.28745-28754, 2006. ,
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes, J Lipid Res, vol.51, pp.832-842, 2010. ,
Insulin is a dominant suppressor of sterol 12?-hydroxylase P450 (CYP8B) expression in rat liver: possible role of insulin in circadian rhythm of CYP8B, J Biochem, vol.127, pp.57-64, 2000. ,
Enhanced glucose cycling and suppressed de novo synthesis of glucose-6-phosphate result in a net unchanged hepatic glucose output in ob/ob mice, Diabetologia, vol.47, pp.2022-2031, 2004. ,
Hepatic glucose sensing and integrative pathways in the liver, Cell Mol Life Sci, vol.71, pp.1453-1467, 2014. ,
Mutations in the glucose-6-phosphatasealpha (G6PC) gene that cause type Ia glycogen storage disease, Hum Mutat, vol.29, pp.921-930, 2008. ,
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas, J Hepatol, vol.54, pp.529-537, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00575314
FoxOs function synergistically to promote glucose production, J Biol Chem, vol.285, pp.35245-5248, 2010. ,
Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system, Hum Gene Ther, vol.10, pp.1885-1891, 1999. ,
The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism, Arch Physiol Biochem, vol.118, pp.102-111, 2012. ,
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation, Proc Natl Acad Sci U S A, vol.106, pp.21660-21665, 2009. ,
A simple method for the isolation and purification of total lipids from animal tissues, J Biol Chem, vol.266, pp.497-509, 1957. ,
Methods of enzymatic analysis, vol.1974, pp.1089-1204 ,
Intestinal farnesoid X receptor controls transintestinal cholesterol excretion in mice, Gastroenterology, vol.152, pp.1126-1138, 2017. ,
Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions, J Lipid Res, vol.30, pp.719-730, 1989. ,
Liver receptor homolog 1 is essential for ovulation, Genes Dev, vol.22, pp.1871-1876, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00311099
Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor ? (LXR?) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1, Biochem J, vol.432, pp.249-254, 2010. ,
Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein, J Biol Chem, vol.278, pp.41930-41937, 2003. ,
Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood, J Lipid Res, vol.44, pp.859-866, 2003. ,
A link between hepatic glucose production and peripheral energy metabolism via hepatokines, Mol Metab, vol.3, pp.531-543, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01350728
Genome-wide analysis of ChREBP binding sites on male mouse liver and white adipose chromatin, Endocrinology, vol.156, pp.1982-1994, 2015. ,
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha, J Lipid Res, vol.47, pp.215-227, 2006. ,
Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes, J Biol Chem, vol.276, pp.16033-16039, 2001. ,
A novel factor binding to the glucose response elements of liver pyruvate kinase and fatty acid synthase genes, J Biol Chem, vol.274, pp.1100-1107, 1999. ,
BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver, Metabolism, vol.65, pp.1478-1488, 2016. ,
ATP-citrate lyase links cellular metabolism to histone acetylation, Science, vol.324, pp.1076-1080, 2009. ,
Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption, Am J Physiol Endocrinol Metab, vol.313, pp.121-133, 2017. ,
Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse, Am J Physiol Gastrointest Liver Physiol, vol.285, pp.494-502, 2003. ,
Mice abundant in muricholic bile acids show resistance to dietary induced steatosis, weight gain, and to impaired glucose metabolism, PLoS One, vol.11, p.147772, 2016. ,
Expression of sterol 12?-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo, Gastroenterology, vol.120, pp.1801-1809, 2001. ,
The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies, J Steroid Biochem Mol Biol, vol.169, pp.111-122, 2017. ,
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity, J Biol Chem, vol.287, pp.1861-1873, 2012. ,
Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats, Gastroenterology, vol.122, pp.1842-1852, 2002. ,
Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptor-and liver X receptor?-controlled metabolic pathways in mice, Hepatology, vol.51, pp.806-816, 2010. ,
ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver, J Biol Chem, vol.281, pp.28721-28730, 2006. ,
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice, FASEB J, vol.32, pp.3792-3802, 2018. ,
Fat malabsorption in essential fatty aciddeficient mice is not due to impaired bile formation, Am J Physiol Gastrointest Liver Physiol, vol.283, pp.900-908, 2002. ,
Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans, J Lipid Res, vol.57, pp.2130-2137, 2016. ,
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice, Diabetes, vol.55, pp.2159-2170, 2006. ,
Decreased transcription of ChREBP-?/? isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia, Diabetes, vol.62, pp.837-844, 2013. ,
De novo lipogenesis in human fat and liver is linked to ChREBP-? and metabolic health, Nat Commun, vol.4, p.1528, 2013. ,
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