B. J. Nankivell, R. J. Borrows, C. L. Fung, P. J. O'connell, R. D. Allen et al., The natural history of chronic allograft nephropathy, N Engl J Med, vol.349, issue.24, pp.2326-2333, 2003.

R. Zeiser and B. R. Blazar, Pathophysiology of chronic graft-versus-host disease and therapeutic targets, N Engl J Med, vol.377, issue.26, pp.2565-2579, 2017.

R. Zeiser and B. R. Blazar, Acute graft-versus-host disease -biologic process, prevention, and therapy, N Engl J Med, vol.377, issue.22, pp.2167-2179, 2017.

B. Ezekian, P. M. Schroder, K. Freischlag, J. Yoon, J. Kwun et al., Contemporary strategies and barriers to transplantation tolerance, Transplantation, vol.102, issue.8, pp.1213-1222, 2018.

J. M. Mathew, H. -voss, J. Lefever, and A. , A phase I clinical trial with ex vivo expanded recipient regulatory t cells in living donor kidney transplants, Sci Rep, vol.8, issue.1, p.7428, 2018.

S. Chandran, Q. Tang, and M. Sarwal, Polyclonal regulatory T cell therapy for control of inflammation in kidney transplants, Am J Transplant, vol.17, issue.11, pp.2945-2954, 2017.

S. Todo, K. Yamashita, and R. Goto, A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation, Hepatology, vol.64, issue.2, pp.632-643, 2016.

E. Nishimura, T. Sakihama, R. Setoguchi, K. Tanaka, and S. Sakaguchi, Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp31CD251CD41 regulatory T cells, Int Immunol, vol.16, issue.8, pp.1189-1201, 2004.

O. Joffre, T. Santolaria, and D. Calise, Prevention of acute and chronic allograft rejection with CD41CD251Foxp31 regulatory T lymphocytes, Nat Med, vol.14, issue.1, pp.88-92, 2008.

D. Golshayan, S. Jiang, J. Tsang, M. I. Garin, C. Mottet et al., In vitro-expanded donor alloantigen-specific CD41CD251 regulatory T cells promote experimental transplantation tolerance, Blood, vol.109, issue.2, pp.827-835, 2007.

J. Y. Tsang, Y. Tanriver, and S. Jiang, Conferring indirect allospecificity on CD41CD251 Tregs by TCR gene transfer favors transplantation tolerance in mice, J Clin Invest, vol.118, issue.11, pp.3619-3628, 2008.

A. L. Putnam, N. Safinia, and A. Medvec, Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation, Am J Transplant, vol.13, issue.11, pp.3010-3020, 2013.

E. Picarda, S. Bézie, and V. Venturi, MHC-derived allopeptide activates TCR-biased CD81 Tregs and suppresses organ rejection, J Clin Invest, vol.124, issue.6, pp.2497-2512, 2014.

C. H. June and M. Sadelain, Chimeric antigen receptor therapy, N Engl J Med, vol.379, issue.1, pp.64-73, 2018.

C. R. Maldini, G. I. Ellis, and J. L. Riley, CAR T cells for infection, autoimmunity and allotransplantation, Nat Rev Immunol, vol.18, issue.10, pp.605-616, 2018.

F. Noyan, K. Zimmermann, and M. Hardtke-wolenski, Prevention of allograft rejection by use of regulatory T cells with an MHC-specific chimeric antigen receptor, Am J Transplant, vol.17, issue.4, pp.917-930, 2017.

K. G. Macdonald, R. E. Hoeppli, and Q. Huang, Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor, J Clin Invest, vol.126, issue.4, pp.1413-1424, 2016.

D. A. Boardman, C. Philippeos, and G. O. Fruhwirth, Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection, Am J Transplant, vol.17, issue.4, pp.931-943, 2017.

S. Bézie, D. Meistermann, and L. Boucault, Ex vivo expanded human non-cytotoxic CD8 1 CD45RC low/-Tregs efficiently delay skin graft rejection and GVHD in humanized mice, Front Immunol, vol.8, 2014.

S. Bézie, I. Anegon, and C. Guillonneau, Advances on CD81 Treg cells and their potential in transplantation, Transplantation, vol.102, issue.9, pp.1467-1478, 2018.

C. Guillonneau, M. Hill, and F. X. Hubert, CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase, J Clin Invest, vol.117, issue.4, pp.1096-1106, 2007.

X. L. Li, S. Ménoret, and S. Bezie, Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance, J Immunol, vol.185, issue.2, pp.823-833, 2010.

E. Xystrakis, A. S. Dejean, and I. Bernard, Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation, Blood, vol.104, issue.10, pp.3294-3301, 2004.

E. Picarda, S. Bézie, and L. Boucault, Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells, JCI Insight, vol.2, issue.3, p.90088, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01833115

Z. Dai, S. Zhang, and Q. Xie, Natural CD81CD1221 T cells are more potent in suppression of allograft rejection than CD41CD251 regulatory T cells, Am J Transplant, vol.14, issue.1, pp.39-48, 2014.

S. Bézie, E. Picarda, and J. Ossart, IL-34 is a Treg-specific cytokine and mediates transplant tolerance, J Clin Invest, vol.125, issue.10, pp.3952-3964, 2015.

A. J. Beres, D. Haribhai, A. C. Chadwick, P. J. Gonyo, C. B. Williams et al., CD81 Foxp31 regulatory T cells are induced during graft-versus-host disease and mitigate disease severity, J Immunol, vol.189, issue.1, pp.464-474, 2012.

J. Heinrichs, J. Li, and H. Nguyen, CD8(1) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(1) Tregs in mice, OncoImmunology, vol.5, issue.6, p.1146842, 2016.

N. M. Lerret, J. L. Houlihan, T. Kheradmand, K. L. Pothoven, Z. J. Zhang et al., Donor-specific CD81 Foxp31 T cells protect skin allografts and facilitate induction of conventional CD41 Foxp31 regulatory T cells, Am J Transplant, vol.12, issue.9, pp.2335-2347, 2012.

S. Bézie, E. Picarda, and L. Tesson, Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells, PLoS One, vol.10, issue.3, p.119686, 2015.

P. Tonnerre, N. Gérard, and M. Chatelais, MICA variant promotes allosensitization after kidney transplantation, J Am Soc Nephrol, vol.24, issue.6, pp.954-966, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-02165869

B. R. Blazar, K. Macdonald, and G. R. Hill, Immune regulatory cell infusion for graft-versus-host disease prevention and therapy, Blood, vol.131, issue.24, pp.2651-2660, 2018.

E. Picarda, I. Anegon, and C. Guillonneau, T-cell receptor specificity of CD8(1) Tregs in allotransplantation, Immunotherapy, vol.3, issue.4, pp.35-37, 2011.

G. Gross, T. Waks, and Z. Eshhar, Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity, Proc Natl Acad Sci, vol.86, issue.24, pp.10024-10028, 1989.

M. Sadelain, I. Rivière, and S. Riddell, Therapeutic T cell engineering, Nature, vol.545, issue.7655, pp.423-431, 2017.

E. Elinav, T. Waks, and Z. Eshhar, Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice, Gastroenterology, vol.134, issue.7, pp.2014-2024, 2008.

J. M. Nunes, S. Buhler, D. Roessli, and A. Sanchez-mazas, HLA-net 2013 collaboration. The HLA-net GENE[RATE] pipeline for effective HLA data analysis and its application to 145 population samples from Europe and neighbouring areas, Tissue Antigens, vol.83, issue.5, pp.307-323, 2014.

C. Burt, C. Cryer, S. Fuggle, A. M. Little, P. Dyer et al., -DR allele group frequencies in 7007 kidney transplant list patients in 27 UK centres, Int J Immunogenet, vol.40, issue.3, pp.209-215, 2013.

S. Ménoret, L. H. Ouisse, and L. Tesson, Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models, Transplantation, vol.102, issue.8, pp.1271-1278, 2018.

D. Sommermeyer, M. Hudecek, and P. L. Kosasih, Chimeric antigen receptor-modified T cells derived from defined CD81 and CD41 subsets confer superior antitumor reactivity in vivo, Leukemia, vol.30, issue.2, pp.492-500, 2016.

S. Jiang, O. Herrera, and R. I. Lechler, New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance, Curr Opin Immunol, vol.16, issue.5, pp.550-557, 2004.

P. Sagoo, N. Ali, G. Garg, F. O. Nestle, R. I. Lechler et al., Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells, Sci Transl Med, vol.3, issue.83, pp.83-125, 2011.

K. Lee, V. Nguyen, K. M. Lee, S. M. Kang, and Q. Tang, Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy, Am J Transplant, vol.14, issue.1, pp.27-38, 2014.

S. Landwehr-kenzel, F. Issa, and S. H. Luu, Novel GMP-compatible protocol employing an allogeneic B cell bank for clonal expansion of allospecific natural regulatory T cells, Am J Transplant, vol.14, issue.3, pp.594-606, 2014.

M. Chmielewski, A. Hombach, C. Heuser, G. P. Adams, and H. Abken, T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity, J Immunol, vol.173, issue.12, pp.7647-7653, 2004.

A. Varela-rohena, P. E. Molloy, and S. M. Dunn, Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor, Nat Med, vol.14, issue.12, pp.1390-1395, 2008.

G. Plesa, L. Zheng, and A. Medvec, TCR affinity and specificity requirements for human regulatory T-cell function, Blood, vol.119, issue.15, pp.3420-3430, 2012.

J. Y. Tsang, K. Ratnasothy, and D. Li, The potency of allospecific Tregs cells appears to correlate with T cell receptor functional avidity, Am J Transplant, vol.11, issue.8, pp.1610-1620, 2011.

D. Sommermeyer, T. Hill, and S. M. Shamah, Fully human CD19-specific chimeric antigen receptors for T-cell therapy, Leukemia, vol.31, issue.10, pp.2191-2199, 2017.

L. H. Ouisse, L. Gautreau-rolland, and M. C. Devilder, Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies, BMC Biotechnol, vol.17, issue.1, p.3, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01444749

A. H. Long, W. M. Haso, and J. F. Shern, 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors, Nat Med, vol.21, issue.6, pp.581-590, 2015.