Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press - Archive ouverte HAL Access content directly
Journal Articles Tumor Biology Year : 2014

Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press

(1, 2) , (1, 2)
1
2

Abstract

Gao and collaborators (Tumour Biol, 2013) have investigated the role of mucin 4 (MUC4) in lung cancer and have concluded that a loss of MUC4 results in epithelial mesenchymal transition via beta-catenin nuclear translocation and that MUC4 expression is correlated with a risk of lymph node metastasis in a cohort of 20 lung adenocarcinoma patients. This surprising analysis is contradictory to most of the scientific knowledge and literature regarding MUC4 contribution in epithelial cancers that is very hardly discussed in their manuscript.
Fichier principal
Vignette du fichier
The relation between MUC4 and EMT is conflicting since MUC4 was shown to suppress EMT in lung adenocarcinoma.pdf (13.61 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-02371186 , version 1 (19-11-2019)

Identifiers

Cite

Nicolas Jonckheere, Isabelle van Seuningen. Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press. Tumor Biology, 2014, 35 (4), pp.3941-3942. ⟨10.1007/s13277-013-1390-y⟩. ⟨inserm-02371186⟩

Collections

INSERM UNIV-LILLE
29 View
104 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More