Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment, Development, vol.137, pp.2483-2492, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-02193451
The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCdelta-dependent inhibition of the AKT pathway, EMBO Mol Med, vol.8, pp.511-526, 2016. ,
Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy, Cell Death Differ, vol.21, pp.1119-1131, 2014. ,
Chromatin signatures of pluripotent cell lines, Nat Cell Biol, vol.8, pp.532-538, 2006. ,
High-resolution profiling of histone methylations in the human genome, Cell, vol.129, pp.823-837, 2007. ,
A bivalent chromatin structure marks key developmental genes in embryonic stem cells, Cell, vol.125, pp.315-326, 2006. ,
The mammalian epigenome, Cell, vol.128, pp.669-681, 2007. ,
The Wnt cries many: Wnt regulation of neurogenesis through tissue patterning, proliferation, and asymmetric cell division, Dev Neurobiol, vol.74, pp.772-780, 2014. ,
GlioVis data portal for visualization and analysis of brain tumor expression datasets, Neuro Oncol, vol.19, pp.139-141, 2017. ,
Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs, Cell Stem Cell, vol.10, pp.157-170, 2012. ,
Comparison of proliferation indices in glioblastoma multiforme by whole tissue section vs tissue microarray, Am J Clin Pathol, vol.120, pp.902-908, 2003. ,
Integrative analysis of 111 reference human epigenomes, Nature, vol.518, pp.317-330, 2015. ,
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation, Cell Stem Cell, vol.4, pp.80-93, 2009. ,
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res, vol.37, pp.1-13, 2009. ,
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat Protoc, vol.4, pp.44-57, 2009. ,
DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01984521
Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture, Toxicol Sci, vol.103, pp.191-206, 2008. ,
ARNT2, a transcription factor for brain neuron survival?, Eur J Neurosci, vol.11, pp.1545-1553, 1999. ,
Two splice variants of the hypoxia-inducible factor HIF-1alpha as potential dimerization partners of ARNT2 in neurons, Eur J Neurosci, vol.12, pp.3701-3708, 2000. ,
Gene expression omnibus: NCBI gene expression and hybridization array data repository, Nucleic Acids Res, vol.30, pp.207-210, 2002. ,
A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma, Acta Neuropathol, vol.133, pp.645-660, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01481051
The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network, Cell Death Differ, vol.19, pp.232-244, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00655645
Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth, Cell Death Dis, vol.8, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01541413
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake, Nat Neurosci, vol.16, pp.1373-1382, 2013. ,
Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway, EMBO Rep, vol.12, pp.470-476, 2011. ,
Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma, Hum Mutat, vol.31, pp.1186-1199, 2010. ,
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells, Cell, vol.146, pp.633-644, 2011. ,
Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011. ,
Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR, Nucleic Acids Res, vol.39, pp.3695-3709, 2011. ,
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential, Cell Death Differ, vol.19, pp.428-439, 2012. ,
SOX9-mediated upregulation of LGR5 is important for glioblastoma tumorigenicity, Biochem Biophys Res Commun, vol.460, pp.216-221, 2015. ,
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt), Mol Cell Biol, vol.16, pp.1706-1713, 1996. ,
Acidic stress promotes a glioma stem cell phenotype, Cell Death Differ, vol.18, pp.829-840, 2011. ,
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays, J Immunol Methods, vol.347, pp.70-78, 2009. ,
Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice, J Neurosurg, vol.83, pp.308-315, 1995. ,
The role of Notch signaling in adult neurogenesis, Mol Neurobiol, vol.44, pp.7-12, 2011. ,
Regulation of pluripotency and self-renewal of ESCs through epigenetic-threshold modulation and mRNA pruning, Cell, vol.151, pp.576-589, 2012. ,
Wnt/beta-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells, Neuro Oncol, vol.15, pp.161-171, 2013. ,
ARNT2 regulates tumoral growth in oral squamous cell carcinoma, J Cancer, vol.7, pp.702-710, 2016. ,
Tcf3 represses Wnt-beta-catenin signaling and maintains neural stem cell population during neocortical development, PLoS One, vol.9, 2014. ,
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines, Cancer Cell, vol.9, pp.391-403, 2006. ,
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells, Cancer Cell, vol.15, pp.501-513, 2009. ,
Downregulation of ARNT2 promotes tumor growth and predicts poor prognosis in human hepatocellular carcinoma, J Gastroenterol Hepatol, vol.30, pp.1085-1093, 2015. ,
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma, Neuron, vol.53, pp.503-517, 2007. ,
Crystal structure of the nucleosome core particle at 2.8 A resolution, Nature, vol.389, pp.251-260, 1997. ,
The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia, Biochem Biophys Res Commun, vol.273, pp.231-238, 2000. ,
A HIF-1alpha-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT, Cell Death Dis, vol.7, 2016. ,
Drug metabolism-related genes as potential biomarkers: analysis of expression in normal and tumour breast tissue, Breast Cancer Res Treat, vol.110, pp.521-530, 2008. ,
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity, Proc Natl Acad Sci, vol.112, pp.851-856, 2015. ,
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells, Nature, vol.448, pp.553-560, 2007. ,
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors, Mol Cell, vol.30, pp.755-766, 2008. ,
Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma, Cancer Res, vol.73, pp.4559-4570, 2013. ,
Wholegenome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells, Cell Stem Cell, vol.1, pp.299-312, 2007. ,
Molecular heterogeneity in glioblastoma: potential clinical implications, Front Oncol, vol.5, p.55, 2015. ,
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma, Science, vol.344, pp.1396-1401, 2014. ,
CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors, BMC Cancer, vol.10, p.66, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00663773
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells, Nature, vol.444, pp.761-765, 2006. ,
Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution, Oncogene, vol.28, pp.1807-1811, 2009. ,
siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells, FEBS Lett, vol.585, pp.3310-3315, 2011. ,
Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression, Am J Pathol, vol.177, pp.1969-1976, 2010. ,
The role of hypoxia-inducible factors in tumorigenesis, Cell Death Differ, vol.15, pp.678-685, 2008. ,
Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors, Neuro Oncol, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01366707
Alternative lengthening of telomeres in human glioma stem cells, Stem Cells, vol.29, pp.440-451, 2011. ,
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics, Proc Natl Acad Sci, vol.110, pp.4009-4014, 2013. ,
Signals and combinatorial functions of histone modifications, Annu Rev Biochem, vol.80, pp.473-499, 2011. ,
Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2, Biochem J, vol.461, pp.403-412, 2014. ,
DLG1/SAP97 modulates transforming growth factor alpha bioavailability, Biochim Biophys Acta, vol.1793, pp.264-272, 2009. ,
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells, Cell, vol.157, pp.580-594, 2014. ,
STRING v10: protein-protein interaction networks, integrated over the tree of life, Nucleic Acids Res, vol.43, pp.447-452, 2015. ,
Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor, Stem Cells, vol.30, pp.845-853, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01541440
Tumorigenic potential of miR-18A* in glioma initiating cells requires NOTCH-1 signaling, Stem Cells, vol.31, pp.1252-1265, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00811588
Notch promotes radioresistance of glioma stem cells, Stem Cells, vol.28, pp.17-28, 2010. ,
The human glioblastoma cell culture resource: validated cell models representing all molecular subtypes, EBioMedicine, vol.2, pp.1351-1363, 2015. ,
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal, Nat Cell Biol, vol.13, pp.762-770, 2011. ,
NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53, EMBO J, vol.29, pp.2659-2674, 2010. ,
Model-based analysis of ChIP-Seq (MACS), Genome Biol, vol.9, issue.9, 2008. ,
FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis, Cancer Cell, vol.20, pp.427-442, 2011. ,
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells, Cell Stem Cell, vol.1, pp.286-298, 2007. ,
regulates Wnt signaling to impede differentiation in neural stem cells and gliomas, Cancer Cell, vol.17, pp.497-509, 2010. ,