The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

Abstract : Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics.
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Lucrezia Cellai, Kevin Carvalho, Emilie Faivre, Aude Deleau, Didier Vieau, et al.. The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease. Frontiers in Neuroscience, Frontiers, 2018, 12, pp.520. ⟨10.3389/fnins.2018.00520⟩. ⟨inserm-02350079⟩

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