Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation, Nature, vol.419, pp.162-167, 2002. ,
The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis, J. Gastroenterol, vol.49, pp.9-23, 2014. ,
AMPK/LKB1 signaling in epithelial cell polarity and cell division, Cell Cycle, vol.6, pp.2755-2759, 2007. ,
Polyploidization of liver cells, Adv. Exp. Med. Biol, vol.676, pp.123-135, 2010. ,
The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents, J. Clin. Invest, vol.119, pp.1880-1887, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00404399
Aneuploidy, polyploidy and ploidy reversal in the liver, Semin. Cell Dev. Biol, vol.24, pp.347-356, 2013. ,
The ploidy conveyor of mature hepatocytes as a source of genetic variation, Nature, vol.467, pp.707-710, 2010. ,
Aneuploidy as a mechanism for stressinduced liver adaptation, J. Clin. Invest, vol.122, pp.3307-3315, 2012. ,
Involvement of the innate immune system in liver regeneration and injury, J. Hepatol, vol.45, pp.347-349, 2006. ,
The role of hepatocytes and oval cells in liver regeneration and repopulation, Mech. Dev, vol.120, pp.117-130, 2003. ,
, Liver regeneration. Hepatology 43, pp.45-53, 2006.
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state, J. Clin. Invest, vol.120, pp.2355-2369, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00495746
Polyploidization in liver tissue, Am. J. Pathol, vol.184, pp.322-331, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01074730
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation, Diabetes, vol.55, pp.865-874, 2006. ,
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome, Nature, vol.391, pp.184-187, 1998. ,
Elucidating the metabolic regulation of liver regeneration, Am. J. Pathol, vol.184, pp.309-321, 2014. ,
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism, Physiol. Rev, vol.89, pp.777-798, 2009. ,
LKB1 and Notch pathways interact and control biliary morphogenesis, PLoS One, vol.10, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-01281665
EGFR signaling in liver diseases, Int. J. Mol. Sci, vol.17, p.30, 2016. ,
Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes, J. Cell Biol, vol.203, pp.251-264, 2013. ,
Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen-induced liver growth, Carcinogenesis, vol.14, pp.1825-1830, 1993. ,
AMPKa1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression, J. Hepatol, vol.60, pp.152-159, 2014. ,
Hepatostat: liver regeneration and normal liver tissue maintenance, Hepatology, vol.65, pp.1384-1392, 2017. ,
Liver regeneration, growth factors, and amphiregulin, Gastroenterology, vol.128, pp.503-506, 2005. ,
Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration, Curr. Biol, vol.22, pp.1166-1175, 2012. ,
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway, Nat. Cell Biol, vol.16, pp.108-117, 2014. ,
Targeting LKB1 in cancerexposing and exploiting vulnerabilities, Br. J. Cancer, vol.113, pp.574-584, 2015. ,
LKB1 and AMP-activated protein kinase: regulators of cell polarity, Genes Cells, vol.17, pp.737-747, 2012. ,
Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice, Cancer Res, vol.62, pp.4549-4553, 2002. ,
The tumor suppressor kinase LKB1: lessons from mouse models, J. Mol. Cell Biol, vol.3, pp.330-340, 2011. ,
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver, Nat. Commun, vol.5, p.4535, 2014. ,
Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo, Hepatology, vol.64, pp.1317-1329, 2016. ,
Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint, Dev. Cell, vol.7, pp.637-651, 2004. ,
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression, Nat. Rev. Cancer, vol.9, pp.563-575, 2009. ,
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin, Science, vol.310, pp.1642-1646, 2005. ,
LKB1 loss of function studied in vivo, FEBS Lett, vol.585, pp.958-966, 2011. ,
Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes, PLoS Biol, vol.11, p.1001739, 2013. ,
, , 2014.
, The special case of hepatocytes: unique tissue architecture calls for a distinct mode of cell division, Bioarchitecture, vol.4, pp.47-52
A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver, Hepatology, vol.35, pp.1072-1081, 2002. ,
Activation of b-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice, Gastroenterology, vol.147, pp.690-701, 2014. ,
Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis, Gut, vol.54, pp.297-302, 2005. ,
Impaired liver regeneration in mice lacking glycine N-methyltransferase, Hepatology, vol.50, pp.443-452, 2009. ,
Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation, Hepatology, vol.49, pp.608-617, 2009. ,
Hepatocyte polyploidization and its association with pathophysiological processes, Cell Death Dis, vol.8, p.2805, 2017. ,
The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells, PLoS One, vol.7, 2012. ,
p21 is required for dextrose-mediated inhibition of mouse liver regeneration, Hepatology, vol.50, pp.207-215, 2009. ,
LKB1 and AMPK in cell polarity and division, Trends Cell Biol, vol.18, pp.193-198, 2008. ,
LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice, Biochem. J, vol.434, pp.49-60, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00560694