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, Benoit Viollet
, Jiri Neuzil
, Jorge Joven
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URL : https://hal.archives-ouvertes.fr/inserm-02135382
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Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway, Cell Metabolism, vol.14, pp.161-172, 2011. ,
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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response, Nature, vol.488, pp.404-408, 2012. ,
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Basal/ HER2 breast carcinomas: Integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin), Cell Cycle, vol.12, pp.225-245, 2013. ,
The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner, Aging Cell, vol.10, pp.980-990, 2011. ,
Circulating nucleosomes and nucleosome modifications as biomarkers in cancer, Cancers, vol.9, 2017. ,
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Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome, Genome Research, vol.23, pp.260-269, 2013. ,
Metformin prevents tobacco carcinogen-induced lung tumorigenesis, Cancer Prevention Research, vol.3, pp.1066-1076, 2010. ,
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Mitochondrial metabolites extend lifespan, Aging Cell, vol.15, pp.336-348, 2016. ,
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How to winnow actives from inactives: Introducing molecular orthogonal sparse bigrams (MOSBs) and multiclass Winnow, Journal of Chemical Information and Modeling, vol.48, pp.306-318, 2008. ,
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Safety and efficacy of neoadjuvant metformin with trastuzumab and chemotherapy in women with HER2-positive early breast cancer: A randomized, open-label, multicenter, phase 2 trial, San Antonio Breast Cancer Symposium (SABCS, 2017. ,
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Dose translation from animal to human studies revisited, FASEB Journal, vol.22, pp.659-661, 2008. ,
Metformin potentiates the benefits of dietary restraint: A metabolomic study, International Journal of Molecular Sciences, vol.18, 2017. ,
GSKJ4, a selective jumonji H3K27 demethylase inhibitor, effectively targets ovarian cancer stem cells, Anticancer Research, vol.35, pp.6607-6614, 2015. ,
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome, Nature Medicine, vol.11, pp.440-445, 2005. ,
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H3K36 methylation promotes longevity by enhancing transcriptional fidelity, Genes & Development, vol.29, pp.1362-1376, 2015. ,
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Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape, 2013. ,
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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging, Proceedings of the National Academy of Sciences of the United States of America, vol.103, pp.8703-8708, 2006. ,
Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents, Biochemical Pharmacology, vol.66, issue.03, pp.338-339, 2003. ,
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Naked mole rat cells have a stable epigenome that resists iPSC reprogramming, Stem Cell Reports, vol.9, pp.1721-1734, 2017. ,
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Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates, Journal of Molecular Biology, vol.429, pp.2895-2906, 2017. ,
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Phosphorylation of EZH2 by AMPK suppresses PRC2 methyltransferase activity and oncogenic function, Molecular Cell, vol.69, pp.279-291, 2018. ,
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, , 2017.
, H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells, GSKJ4, an, vol.359, pp.405-414
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Metformin directly targets the H3K27me3 demethylase KDM6A/UTX, Aging Cell, vol.17, p.12772, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02349904
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