Investigation of the role of FcR and FcRn in mAb distribution to the brain, Mol Pharm, vol.10, pp.1505-1518, 2013. ,
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein, J Neurosci, vol.22, pp.9340-51, 2002. ,
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules, Nat Med, vol.2, pp.783-790, 1996. ,
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity, Acta Neuropathol, vol.127, pp.667-83, 2014. ,
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements, J Neurosci, vol.27, pp.9115-9144, 2007. ,
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease, Acta Neuropathol, vol.103, pp.26-35, 2002. ,
Tau protein quantification in human cerebrospinal fluid by targeted mass spectrometry at high sequence coverage provides insights into its primary structure heterogeneity, J Proteome Res, vol.15, pp.667-76, 2016. ,
Differential mass spectrometry profiles of tau protein in the cerebrospinal fluid of patients with Alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies, J Alzheimers Dis, vol.51, pp.1033-1076, 2016. ,
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain, J Neurochem, vol.118, pp.658-67, 2011. ,
Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol, vol.82, pp.239-59, 1991. ,
Alzheimer's pathogenesis: is there neuron-toneuron propagation?, Acta Neuropathol, vol.121, pp.589-95, 2011. ,
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders, Brain Res Brain Res Rev, vol.33, pp.95-130, 2000. ,
AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease, Brain Res Mol Brain Res, vol.39, pp.79-88, 1996. ,
Synaptic contacts enhance cell-to-cell tau pathology propagation, Cell Rep, vol.11, pp.1176-83, 2015. ,
Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model, J Neurosci, vol.35, pp.4857-68, 2015. ,
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles, J Neurosci, vol.34, pp.4260-72, 2014. ,
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression, J Biol Chem, vol.286, pp.34457-67, 2011. ,
In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum, Ann Neurol, vol.80, pp.247-58, 2016. ,
Transmission and spreading of tauopathy in transgenic mouse brain, Nat Cell Biol, vol.11, pp.909-922, 2009. ,
Grü ninger F. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease, Brain, vol.137, pp.2834-2880, 2014. ,
Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy, Mol Neurodegener, vol.11, p.62, 2016. ,
Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy, Brain, vol.141, pp.550-67, 2018. ,
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau, Acta Neuropathol, vol.136, pp.729-774, 2018. ,
Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures, Cell Death Dis, vol.8, p.2671, 2017. ,
Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity, PLoS One, vol.8, p.62402, 2013. ,
Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies, J Neural Transm, vol.122, pp.607-624, 2015. ,
Tau passive immunization inhibits not only tau but also Ab pathology, Alzheimers Res Ther, vol.9, p.1, 2017. ,
Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 Â Tg-AD mice, Alzheimers Res Ther, vol.10, p.13, 2018. ,
Propagation of tau pathology in a model of early Alzheimer's disease, Neuron, vol.73, pp.685-97, 2012. ,
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease, Neurology, vol.52, pp.1158-65, 1999. ,
Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms, Sci Rep, vol.5, p.9659, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01659458
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies, Acta Neuropathol Commun, vol.2, p.14, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-00945726
Ectosomes: a new mechanism for non-exosomal secretion of tau protein, PLoS ONE, vol.9, p.100760, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01181185
Modeling the relation between neurofibrillary tangles and intellectual status, Neurobiol Aging, vol.18, pp.267-73, 1997. ,
Seeding and propagation of lesions in neurodegenerative diseases: a new paradigm, Bull Acad Natl Med, vol.199, pp.809-828, 2015. ,
Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat, Brain, vol.141, pp.535-584, 2018. ,
Methods for measuring tau pathology in transgenic mouse models, J Alzheimers Dis, vol.33, pp.463-71, 2013. ,
Distinct therapeutic mechanisms of tau antibodies: promoting microglial clearance versus blocking neuronal uptake, J Biol Chem, vol.290, pp.21652-62, 2015. ,
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease, Neuron, vol.3, pp.519-545, 1989. ,
Intracellular and extracellular roles for tau in neurodegenerative disease, J Alzheimers Dis, vol.40, issue.1, pp.37-45, 2014. ,
Networks of tau distribution in Alzheimer's disease, Brain, vol.14, pp.568-81, 2018. ,
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury, J Neurosci, vol.34, pp.16180-93, 2014. ,
A walk through tau therapeutic strategies, Acta Neuropathol Commun, vol.7, p.22, 2019. ,
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau, J Neurosci Res, vol.48, pp.128-160, 1997. ,
Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice, Am J Pathol, vol.171, pp.976-92, 2007. ,
What is the evidence that tau pathology spreads through prion-like propagation?, Acta Neuropathol Commun, vol.5, p.99, 2017. ,
Accelerated filament formation from tau protein with specific FTDP-17 missense mutations, FEBS Lett, vol.447, pp.195-204, 1999. ,
Tau antibody targeting pathological species blocks neuronal uptake and interneuron propagation of tau in Vitro, Am J Pathol, vol.187, pp.1399-412, 2017. ,
Tau immunotherapy for Alzheimer's disease, Trends Mol Med, vol.21, pp.394-402, 2015. ,
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice, Neurobiol Dis, vol.73, pp.83-95, 2015. ,
Staging of argyrophilic grains: an age-associated tauopathy, J Neuropathol Exp Neurol, vol.63, pp.911-919, 2004. ,
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models, PLoS One, vol.10, p.125614, 2015. ,
Tau Kinetics in neurons and the human central nervous system, Neuron, vol.98, pp.861-64, 2018. ,
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits, Am J Pathol, vol.169, pp.599-616, 2006. ,
Atypical, non-standard functions of the microtubule associated Tau protein, Acta Neuropathol Commun, vol.5, p.91, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01654098
Frontotemporal dementia and parkinsonism linked to chromosome 17: a new group of tauopathies, Brain Pathol, vol.8, pp.387-402, 1998. ,
Brain bioavailability of human intravenous immunoglobulin and its transport through the murine blood-brain barrier, J Cereb Blood Flow Metab, vol.33, pp.1983-92, 2013. ,
Transneuronal degeneration in the spread of Alzheimer's disease pathology: immunohistochemical evidence for the transmission of tau hyperphosphorylation, Neurobiol Dis, vol.4, pp.365-75, 1997. ,
Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice, J Biol Chem, vol.280, pp.3963-73, 2005. ,
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach, Curr Alzheimer Res, vol.9, pp.397-405, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00664452
Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice, Ann Clin Transl Neurol, vol.2, pp.241-55, 2015. ,
Anti-Tau monoclonal antibodies derived from soluble and filamentous tau show diverse functional properties in vitro and in vivo, J Alzheimers Dis, vol.65, pp.265-81, 2018. ,
The significance of cortical pathology in progressive supranuclear palsy. Clinico-pathological data in 10 cases, Brain, vol.119, pp.1123-1159, 1996. ,
Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau, J Biol Chem, vol.274, pp.7368-78, 1999. ,
A protein factor essential for microtubule assembly, Proc Natl Acad Sci, vol.72, pp.1858-62, 1975. ,
Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome, Brain, vol.130, pp.1566-76, 2007. ,
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease, Proc Natl Acad Sci, vol.85, pp.4506-4516, 1988. ,
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy, Sci Transl Med, vol.9, 2017. ,
The selfperpetuating tau truncation circle, Biochem Soc Trans, vol.40, pp.681-687, 2012. ,