Future prospects for CD8 + regulatory T cells in immune tolerance

Abstract : CD8+ Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4+ Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8+ and CD4+ Tregs, and we will discuss the biology, development and induction of CD8+ Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically accessible improvements notably through genetic modifications.
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https://www.hal.inserm.fr/inserm-02341615
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Thursday, October 31, 2019 - 2:42:03 PM
Last modification on : Wednesday, November 6, 2019 - 1:38:47 AM

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Léa Flippe, Séverine Bézie, Ignacio Anegon, Carole Guillonneau. Future prospects for CD8 + regulatory T cells in immune tolerance. Immunological Reviews, Wiley, 2019, ⟨10.1111/imr.12812⟩. ⟨inserm-02341615⟩

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