Skip to Main content Skip to Navigation
Journal articles

Mucins and tumor resistance to chemotherapeutic drugs

Abstract : Epithelial cancer patients not considered eligible for surgical resection frequently benefit from chemotherapy. Chemotherapy is the treatment of cancer with one or combination of cytotoxic or cytostatic drugs. Recent advances in chemotherapy allowed a great number of cancer patients to receive treatment with significant results. Unfortunately, resistance to chemotherapeutic drug treatment is a major challenge for clinicians in the majority of epithelial cancers because it is responsible for the inefficiency of therapies. Mucins belong to a heterogeneous group of large O-glycoproteins that can be either secreted or membrane-bound. Implications of mucins have been described in relation to cancer cell behavior and cell signaling pathways associated with epithelial tumorigenesis. Because of the frequent alteration of the pattern of mucin expression in cancers as well as their structural and functional characteristics, mucins are thought to also be involved in response to therapies. In this report, we review the roles of mucins in chemoresistance and the associated underlying molecular mechanisms (physical barrier, resistance to apoptosis, drug metabolism, cell stemness, epithelial-mesenchymal transition) and discuss the therapeutic tools/strategies and/or prognosis biomarkers for personalized chemotherapy that could be proposed from these studies.
Document type :
Journal articles
Complete list of metadata

Cited literature [145 references]  Display  Hide  Download
Contributor : Nicolas Jonckheere Connect in order to contact the contributor
Submitted on : Thursday, October 31, 2019 - 2:17:23 PM
Last modification on : Wednesday, March 23, 2022 - 3:51:28 PM
Long-term archiving on: : Saturday, February 1, 2020 - 5:42:07 PM


Files produced by the author(s)




Nicolas Jonckheere, Nicolas Skrypek, Isabelle Van Seuningen. Mucins and tumor resistance to chemotherapeutic drugs. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Elsevier, 2014, 1846 (1), pp.142-151. ⟨10.1016/j.bbcan.2014.04.008⟩. ⟨inserm-02341531⟩



Record views


Files downloads