, Cancer Facts and Figures, 2018.

M. Malvezzi, G. Carioli, P. Bertuccio, P. Boffetta, F. Levi et al., European cancer mortality predictions for the year 2018 with focus on colorectal cancer, Ann. Oncol, vol.29, pp.1016-1022, 2018.

. Wcrf/aicr, Continuous Update Project Report: Food, Nutrition, Physical Activity, and the Prevention of Colorectal Cancer, 2011.

K. M. Rank and A. Shaukat, Stool Based Testing for Colorectal Cancer: An Overview of Available Evidence, Curr. Gastroenterol. Rep, vol.19, 2017.

N. N. Rahbari, P. R. Carr, L. Jansen, J. Chang-claude, J. Weitz et al., Time of Metastasis and Outcome in Colorectal Cancer, Ann. Surg, vol.2017

T. Akinyemiju, S. Sakhuja, J. Waterbor, M. Pisu, and S. F. Altekruse, Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer, Cancer Med, vol.7, pp.1183-1193, 2018.

Q. Luo, D. L. O'connell, C. Kahn, and X. Q. Yu, Colorectal cancer metastatic disease progression in Australia: A population-based analysis, Cancer Epidemiol, vol.49, pp.92-100, 2017.

A. R. Benson, A. Venook, L. Cederquist, E. Chan, Y. Chen et al., Clinical Practice Guidelines in Oncology. Natl. Compr. Cancer Netw, vol.3, pp.370-398, 2017.

A. Puccini, M. D. Berger, M. Naseem, R. Tokunaga, F. Battaglin et al., Colorectal cancer: Epigenetic alterations and their clinical implications, Biochim. Biophys. Acta Rev. Cancer, vol.1868, pp.439-448, 2017.

R. Gupta, S. Sinha, and R. N. Paul, The impact of microsatellite stability status in colorectal cancer, Curr. Probl. Cancer, 2018.

A. Sadanandam, C. A. Lyssiotis, K. Homicsko, E. A. Collisson, W. J. Gibb et al., A colorectal cancer classification system that associates cellular phenotype and responses to therapy, Nat. Med, vol.19, pp.619-625, 2013.

J. Guinney, R. Dienstmann, X. Wang, A. De-reyniès, A. Schlicker et al., The consensus molecular subtypes of colorectal cancer, Nat. Med, vol.21, pp.1350-1356, 2015.

S. Merkel, V. S. Schellerer, A. Wein, S. Semrau, C. Geppert et al., The influence of tumour site on prognosis in metastatic colorectal carcinomas with primary tumour resection, Int. J. Color. Dis, vol.33, pp.1215-1223, 2018.

C. Cremolini, C. Antoniotti, S. Lonardi, F. Bergamo, E. Cortesi et al., Primary Tumor Sidedness and Benefit from FOLFOXIRI plus Bevacizumab as Initial Therapy for Metastatic Colorectal Cancer, Ann. Oncol, 2018.

S. Narayanan, E. Gabriel, K. Attwood, P. Boland, and S. Nurkin, Association of Clinicopathologic and Molecular Markers on Stage-specific Survival of Right Versus Left Colon Cancer, Clin. Color. Cancer, vol.5, 2018.

R. L. Siegel, K. D. Miller, and A. Jemal, Cancer statistics, vol.68, pp.7-30, 2018.

Y. Zhang, Y. Tao, Y. Li, J. Zhao, L. Zhang et al., The regulatory network analysis of long noncoding RNAs in human colorectal cancer, Funct. Integr. Genom, vol.18, pp.261-275, 2018.

M. Sun, F. Nie, Y. Wang, Z. Zhang, J. Hou et al., LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1, Cancer Res, vol.76, pp.6299-6310, 2016.

Y. Wang, L. He, Y. Du, P. Zhu, G. Huang et al., The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling, Cell Stem Cell, vol.16, pp.413-425, 2015.

Z. Chen, Y. Gao, L. Yao, Y. Liu, L. Huang et al., LncFZD6 initiates Wnt/beta-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation, Oncogene, vol.37, pp.3098-3112, 2018.

X. Wang, Y. Gong, B. O. Jin, C. Wu, J. Yang et al., Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells, Oncol. Rep, vol.32, pp.1281-1290, 2014.

W. P. Tsang, E. K. Ng, S. S. Ng, H. Jin, J. Yu et al., Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer, Carcinogenesis, vol.31, pp.350-358, 2010.

I. J. Matouk, E. Raveh, R. Abu-lail, S. Mezan, M. Gilon et al., Oncofetal H19 RNA promotes tumor metastasis, Biochim. Biophys. Acta, vol.7, pp.1414-1426, 2014.

Q. Zhao, T. Li, J. Qi, J. Liu, and C. Qin, The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression, PLoS ONE, vol.9, 2014.

A. Iio, T. Takagi, K. Miki, T. Naoe, A. Nakayama et al., DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells, Biochim. Biophys. Acta, vol.10, pp.1102-1110, 2013.

K. Augoff, B. Mccue, and E. F. Plow, Sossey-Alaoui, K. miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer, Mol. Cancer, vol.11, issue.5, 2012.

S. Emmrich, A. Streltsov, F. Schmidt, V. R. Thangapandi, D. Reinhardt et al., LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia, Mol. Cancer, vol.13, pp.1476-4598, 2014.

D. Sun, R. Layer, A. C. Mueller, M. A. Cichewicz, M. Negishi et al., Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells, Oncogene, vol.33, pp.1448-1457, 2014.

Y. Kotake, K. Kitagawa, T. Ohhata, S. Sakai, C. Uchida et al., Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein, Anticancer Res, vol.36, pp.1605-1611, 2016.

C. Yan, J. Chen, and N. Chen, Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability, Sci. Rep, 2016.

J. H. Yoon, B. H. You, C. H. Park, Y. J. Kim, J. W. Nam et al., The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma, Cancer Lett, vol.417, pp.47-57, 2018.

H. Jiang, T. Li, Y. Qu, X. Wang, B. Li et al., Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression, Cancer Lett, vol.425, pp.78-87, 2018.

A. Nevers, A. Doyen, C. Malabat, B. Neron, T. Kergrohen et al., Antisense transcriptional interference mediates condition-specific gene repression in budding yeast, Nucleic Acids Res, 2018.

L. Muniz, M. K. Deb, M. Aguirrebengoa, S. Lazorthes, D. Trouche et al., Control of Gene Expression in Senescence through Transcriptional Read-Through of Convergent Protein-Coding Genes, vol.21, pp.2433-2446, 2017.

V. Pelechano and L. M. Steinmetz, Gene regulation by antisense transcription, Nat. Rev. Genet, vol.14, pp.880-893, 2013.

C. Li, W. Li, Y. Zhang, X. Zhang, T. Liu et al., Increased expression of antisense lncRNA SPINT1-AS1 predicts a poor prognosis in colorectal cancer and is negatively correlated with its sense transcript, OncoTargets Ther, vol.11, pp.3969-3978, 2018.

J. Yin, W. Luo, X. Zeng, L. Zeng, Z. Li et al., UXT-AS1-induced alternative splicing of UXT is associated with tumor progression in colorectal cancer, Am. J. Cancer Res, vol.7, pp.462-472, 2017.

J. M. Engreitz, J. E. Haines, E. M. Perez, G. Munson, J. Chen et al., Local regulation of gene expression by lncRNA promoters, transcription and splicing, Nature, vol.539, pp.452-455, 2016.

S. Jalali, A. Singh, S. Maiti, and V. Scaria, Genome-wide computational analysis of potential long noncoding RNA mediated DNA:DNA:RNA triplexes in the human genome, J. Transl. Med, vol.15, 2017.

P. P. Amaral, T. Leonardi, N. Han, E. Viré, D. K. Gascoigne et al., Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci, Genome Biol, vol.19, 2018.

J. Xiang, Q. Yin, T. Chen, Y. Zhang, X. Zhang et al., Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus, Cell Res, vol.24, pp.513-531, 2014.

X. Gui, H. Li, T. Li, H. Pu, and D. Lu, Long Noncoding RNA CUDR Regulates HULC and ?-Catenin to Govern Human Liver Stem Cell Malignant Differentiation, Mol. Ther, vol.23, pp.1843-1853, 2015.

T. Mondal, S. Subhash, R. Vaid, S. Enroth, S. Uday et al., MEG3 long noncoding RNA regulates the TGF-? pathway genes through formation of RNA-DNA triplex structures, Nat. Commun, vol.6, 2015.

Y. Zhao, Y. Liu, L. Lin, Q. Huang, W. He et al., The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1, Mol. Cancer, vol.17, 2018.

Y. Pan, Y. Cheng, F. Yang, Z. Yao, and O. Wang, Knockdown of LncRNA MAPT-AS1 inhibites proliferation and migration and sensitizes cancer cells to paclitaxel by regulating MAPT expression in ER-negative breast cancers, Cell Biosci, vol.8, issue.7, 2018.

M. Beltran, I. Puig, C. Pena, J. M. Garcia, A. B. Alvarez et al., A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition, Genes Dev, vol.22, pp.756-769, 2008.

J. Zhuang, Q. Lu, B. Shen, X. Huang, L. Shen et al., TGFbeta1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT, Sci. Rep, vol.5, 2015.

M. R. Fabian and N. Sonenberg, The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC, Nat. Struct. Mol. Biol, vol.19, pp.586-593, 2012.

Y. Tay, J. Rinn, and P. P. Pandolfi, The multilayered complexity of ceRNA crosstalk and competition, Nature, vol.505, pp.344-352, 2014.

S. Yamamura, M. Imai-sumida, Y. Tanaka, and R. Dahiya, Interaction and cross-talk between non-coding RNAs, Cell Mol. Life Sci, vol.75, pp.467-484, 2017.

R. Denzler, S. E. Mcgeary, A. C. Title, V. Agarwal, D. P. Bartel et al., Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression, Mol. Cell, vol.64, pp.565-579, 2016.

J. Li, S. Liu, H. Zhou, L. Qu, and J. Yang, 0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data, Nucleic Acids Res, vol.42, pp.92-97, 2014.

Q. Fan and B. Liu, Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer, OncoTargets Ther, vol.11, pp.2453-2466, 2018.

A. Schein, S. Zucchelli, S. Kauppinen, S. Gustincich, and P. Carninci, Identification of antisense long noncoding RNAs that function as SINEUPs in human cells, Sci. Rep, vol.6, 2016.

G. Hu, Z. Lou, and M. Gupta, The Long Non-Coding RNA GAS5 Cooperates with the Eukaryotic Translation Initiation Factor 4E to Regulate c-Myc Translation, PLoS ONE, vol.9, 2014.

X. Sun, M. S. Haider-ali, and M. Moran, The role of interactions of long non-coding RNAs and heterogeneous nuclear ribonucleoproteins in regulating cellular functions, Biochem. J, vol.474, pp.2925-2935, 2017.

J. Kong, W. Sun, C. Li, L. Wan, S. Wang et al., Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6, Cancer Lett, vol.380, pp.476-484, 2016.

N. Romero-barrios, M. F. Legascue, M. Benhamed, F. Ariel, and M. Crespi, Splicing regulation by long noncoding RNAs, Nucleic Acids Res, vol.46, pp.2169-2184, 2018.

O. Villamizar, C. B. Chambers, J. M. Riberdy, D. A. Persons, and A. Wilber, Long noncoding RNA Saf and splicing factor 45 increase soluble Fas and resistance to apoptosis, Oncotarget, vol.7, pp.13810-13826, 2016.

V. Tripathi, J. D. Ellis, Z. Shen, D. Y. Song, Q. Pan et al., The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation, Mol. Cell, vol.39, pp.925-938, 2010.

B. Liu, L. Sun, Q. Liu, C. Gong, Y. Yao et al., A Cytoplasmic NF-?B Interacting Long Noncoding RNA Blocks I?B Phosphorylation and Suppresses Breast Cancer Metastasis, Cancer Cell, vol.27, pp.370-381, 2015.

A. Lin, C. Li, Z. Xing, Q. Hu, K. Liang et al., The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer, Nat. Cell Biol, vol.18, pp.213-224, 2016.

J. Ruiz-orera, X. Messeguer, J. A. Subirana, and M. M. Alba, Long non-coding RNAs as a source of new peptides, vol.3, 2014.

A. Matsumoto and K. I. Nakayama, Hidden Peptides Encoded by Putative Noncoding RNAs, Cell. Struct. Funct, vol.43, pp.75-83, 2018.

A. Matsumoto, A. Pasut, M. Matsumoto, R. Yamashita, J. Fung et al., P. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide, Nature, vol.541, pp.228-232, 2016.
URL : https://hal.archives-ouvertes.fr/in2p3-00119588

N. G. D'lima, J. Ma, L. Winkler, Q. Chu, K. H. Loh et al., A human microprotein that interacts with the mRNA decapping complex, Nat. Chem. Biol, vol.13, pp.174-180, 2016.

J. Huang, M. Chen, D. Chen, X. Gao, S. Zhu et al., A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth, Mol. Cell, vol.68, pp.171-184, 2017.

J. Carlevaro-fita, A. Rahim, R. Guigó, L. A. Vardy, and R. Johnson, Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells, RNA, vol.22, pp.867-882, 2016.

X. Yan, Z. Hu, Y. Feng, X. Hu, J. Yuan et al., Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers, Cancer Cell, vol.28, pp.529-540, 2015.

J. Li, H. Meng, Y. Bai, and K. Wang, Regulation of lncRNA and Its Role in Cancer Metastasis, Oncol. Res, vol.23, pp.205-217, 2016.

T. Kim and C. M. Croce, Long noncoding RNAs: Undeciphered cellular codes encrypting keys of colorectal cancer pathogenesis, Cancer Lett, vol.417, pp.89-95, 2018.

C. Yang, X. Li, Y. Wang, L. Zhao, and W. Chen, Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells, Gene, vol.496, pp.8-16, 2012.

W. P. Tsang, T. W. Wong, A. H. Cheung, C. N. Co, and T. T. Kwok, Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR, RNA, vol.13, pp.890-898, 2007.

M. Xue, W. Chen, and X. Li, Urothelial cancer associated 1: A long noncoding RNA with a crucial role in cancer, J. Cancer Res. Clin. Oncol, vol.142, pp.1407-1419, 2016.

P. Chen, D. Wan, D. Zheng, Q. Zheng, F. Wu et al., Long non-coding RNA UCA1 promotes the tumorigenesis in pancreatic cancer, Biomed. Pharmacother, vol.83, pp.1220-1226, 2016.

X. Zhang, F. Gao, L. Zhou, H. Wang, G. Shi et al., UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer by Sponging miR-135a, Oncol. Res, vol.25, pp.1529-1541, 2017.

M. Zhang, Y. Zhao, Y. Zhang, D. Wang, S. Gu et al., LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway, Biochim. Biophys. Acta Mol. Basis Dis, vol.1864, pp.1770-1782, 2018.

Y. Han, Y. Yang, H. Yuan, T. Zhang, H. Sui et al., UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution, Pathology, vol.46, pp.396-401, 2014.

B. Ni, X. Yu, X. Guo, X. Fan, Z. Yang et al., Increased urothelial cancer associated 1 is associated with tumor proliferation and metastasis and predicts poor prognosis in colorectal cancer, Int. J. Oncol, vol.47, pp.1329-1338, 2015.

Z. Bian, L. Jin, J. Zhang, Y. Yin, C. Quan et al., LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p, Sci. Rep, 2016.

F. Liu, Q. Dong, H. Gao, and Z. Zhu, The prognostic significance of UCA1 for predicting clinical outcome in patients with digestive system malignancies, Oncotarget, vol.8, p.40620, 2017.

F. Renaud, A. Vincent, C. Mariette, M. Crépin, L. Stechly et al., MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer, Int. J. Cancer, vol.136, pp.2811-2821, 2015.

R. Aguirre-gamboa, H. Gomez-rueda, E. Martinez-ledesma, A. Martinez-torteya, R. Chacolla-huaringa et al., SurvExpress: An online biomarker validation tool and database for cancer gene expression data using survival analysis, PLoS ONE, vol.8, 2013.

W. Wu, S. Zhang, X. Li, M. Xue, S. Cao et al., Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells, PLoS ONE, vol.8, 2013.

Z. K. Zuo, Y. Gong, X. H. Chen, F. Ye, Z. M. Yin et al., TGFbeta1-Induced LncRNA UCA1 Upregulation Promotes Gastric Cancer Invasion and Migration, DNA Cell Biol, vol.36, pp.159-167, 2017.

G. Y. Li, W. Wang, J. Y. Sun, B. Xin, X. Zhang et al., Long non-coding RNAs AC026904.1 and UCA1: A "one-two punch" for TGF-beta-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer, Theranostics, vol.8, pp.2846-2861, 2018.

S. E. Hiemer, A. D. Szymaniak, and X. Varelas, The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor-induced Tumorigenic Phenotypes in Breast Cancer Cells, J. Biol. Chem, vol.289, pp.13461-13474, 2014.

L. Gou, M. Liu, J. Xia, Q. Wan, Y. Jiang et al., BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1, Int. J. Mol. Sci, vol.19, 1116.

M. Xue, W. Chen, A. Xiang, R. Wang, H. Chen et al., Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1, Mol. Cancer, vol.16, 2017.

M. Xue, X. Li, Z. Li, and W. Chen, Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1?-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion, Tumor Biol, vol.35, pp.6901-6912, 2014.

M. E. Xue, X. U. Li, W. Wu, S. Zhang, S. Wu et al., Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein ? contributes to bladder cancer cell growth and reduced apoptosis, Oncol. Rep, vol.31, 1993.

X. Guo, Y. Zhang, A. Mayakonda, V. Madan, L. W. Ding et al., ARID1A and CEBPalpha cooperatively inhibit UCA1 transcription in breast cancer, Oncogene, 2018.

J. Lee, M. Kim, and H. Kim, Epigenetic regulation of long noncoding RNA UCA1 by SATB1 in breast cancer, BMB Rep, vol.49, pp.578-583, 2016.

P. P. Kumar, U. Emechebe, R. Smith, S. Franklin, B. Moore et al., Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex, vol.29, p.2805, 2014.

Y. Zhou, X. Meng, S. Chen, W. Li, D. Li et al., IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p, Breast Cancer Res, 1920.

T. Wang, J. Yuan, N. Feng, Y. Li, Z. Lin et al., Hsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer, Tumour Biol, vol.35, pp.10075-10084, 2014.

J. Huang, N. Zhou, K. Watabe, Z. Lu, F. Wu et al., Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1), Cell Death Dis, vol.5, 1008.

T. Li, Q. Zheng, J. An, M. Wu, H. Li et al., SET1A Cooperates With CUDR to Promote Liver Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation Epigenetically, Mol. Ther, vol.24, pp.261-275, 2016.

M. Corvaisier, M. Bauzone, F. Corfiotti, F. Renaud, M. E. Amrani et al., Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse, Oncotarget, vol.7, p.56699, 2016.

A. Jeggari, D. S. Marks, E. Larsson, and . Mircode, A map of putative microRNA target sites in the long non-coding transcriptome, Bioinformatics, vol.28, pp.2062-2063, 2012.

Z. Li, X. Li, S. Wu, M. Xue, and W. Chen, Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway, Cancer Sci, vol.105, pp.951-955, 2014.

B. Jahangiri, M. Khalaj-kondori, E. Asadollahi, and M. Sadeghizadeh, Cancer-associated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1, Cell Commun. Signal, 2018.

I. S. Vlachos, K. Zagganas, M. D. Paraskevopoulou, G. Georgakilas, D. Karagkouni et al., DIANA-miRPath v3.0: Deciphering microRNA function with experimental support, Nucleic Acids Res, vol.43, 2015.

J. Zheng, D. Yi, Y. Liu, M. Wang, Y. Zhu et al., Long nonding RNA UCA1 regulates neural stem cell differentiation by controlling miR-1/Hes1 expression, Am. J. Transl. Res, vol.9, pp.3696-3704, 2017.

W. Xu, Z. Zhang, K. Zou, Y. Cheng, M. Yang et al., MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis, Cell Death Dis, 2017.

Z. Yang, X. Shi, C. Li, X. Wang, K. Hou et al., Long non-coding RNA UCA1 upregulation promotes the migration of hypoxia-resistant gastric cancer cells through the miR-7-5p/EGFR axis, Exp. Cell Res, vol.368, pp.194-201, 2018.

Y. Li, Y. Liu, P. Xie, F. Li, and G. Li, PAX6, a novel target of microRNA-7, promotes cellular proliferation and invasion in human colorectal cancer cells, Dig. Dis. Sci, vol.59, pp.598-606, 2014.

M. L. Liu, Q. Zhang, X. Yuan, L. Jin, L. L. Wang et al., Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer, World J. Gastroenterol, vol.24, pp.1004-1012, 2018.

Y. Nagano, Y. Toiyama, Y. Okugawa, H. Imaoka, H. Fujikawa et al., MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer, Anticancer Res, vol.36, pp.6521-6526, 2016.

C. Pothoulakis, M. Torre-rojas, M. A. Duran-padilla, J. Gevorkian, O. Zoras et al., Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis, Int. J. Cancer, vol.142, pp.334-346, 2018.

T. Suto, T. Yokobori, R. Yajima, H. Morita, T. Fujii et al., MicroRNA-7 expression in colorectal cancer is associated with poor prognosis and regulates cetuximab sensitivity via EGFR regulation, Carcinogenesis, vol.36, pp.338-345, 2015.

K. Xu, Z. Chen, C. Qin, and X. Song, miR-7 inhibits colorectal cancer cell proliferation and induces apoptosis by targeting XRCC2. OncoTargets Ther, vol.7, pp.325-332, 2014.

C. Y. Zeng, Y. S. Zhan, J. Huang, and Y. X. Chen, MicroRNA7 suppresses human colon cancer invasion and proliferation by targeting the expression of focal adhesion kinase, Mol. Med. Rep, vol.13, pp.1297-1303, 2016.

K. Zeng, X. Chen, M. Xu, X. Liu, X. Hu et al., CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7, Cell Death Dis, vol.9, p.417, 2018.

N. Zhang, X. Li, C. W. Wu, Y. Dong, M. Cai et al., Oncogene, vol.32, pp.5078-5088, 2013.

Y. Xiao, C. Jiao, Y. Lin, M. Chen, J. Zhang et al., lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells, DNA Cell Biol, vol.36, pp.18-25, 2017.

K. Hasakova, J. Bezakova, M. Vician, R. Reis, M. Zeman et al., Gender-dependent expression of leading and passenger strand of miR-21 and miR-16 in human colorectal cancer and adjacent colonic tissues, Physiol. Res, vol.66, pp.575-582, 2017.

H. J. Li, X. Li, H. Pang, J. J. Pan, X. J. Xie et al., Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer, Jpn. J. Clin. Oncol, vol.45, pp.1055-1063, 2015.

H. Zhu, W. Bai, X. Ye, A. Yang, and L. Jia, Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein 1, Biochem. Biophys. Res. Commun, vol.496, pp.1308-1313, 2018.

J. Yue, K. J. Humphreys, R. A. Mckinnon, and M. Z. Michael, miR-18a Inhibits CDC42 and Plays a Tumour Suppressor Role in Colorectal Cancer Cells, PLoS ONE, vol.9, 2014.

X. Li, Y. Wu, A. Liu, and X. Tang, Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1alpha feedback regulatory loop, Tumour Biol, vol.37, pp.14733-14743, 2016.

Q. Fang, X. Chen, and X. Zhi, Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b, Med. Sci. Monit, vol.22, pp.3506-3513, 2016.

Y. Luo, S. Y. Yu, J. J. Chen, J. Qin, Y. E. Qiu et al., MiR-27b directly targets Rab3D to inhibit the malignant phenotype in colorectal cancer, Oncotarget, vol.9, pp.3830-3841, 2018.

Y. Zhou, Y. Chen, W. Ding, Z. Hua, L. Wang et al., LncRNA UCA1 impacts cell proliferation, invasion, and migration of pancreatic cancer through regulating miR-96/FOXO3, IUBMB Life, 2018.

Y. Iseki, M. Shibutani, K. Maeda, H. Nagahara, T. Fukuoka et al., MicroRNA-96 Promotes Tumor Invasion in Colorectal Cancer via RECK, Anticancer Res, vol.38, pp.2031-2035, 2018.

S. Rapti, C. K. Kontos, I. N. Papadopoulos, and A. Scorilas, High miR-96 levels in colorectal adenocarcinoma predict poor prognosis, particularly in patients without distant metastasis at the time of initial diagnosis, Tumor Biol, vol.37, pp.11815-11824, 2016.

Y. Sun, J. G. Jin, W. Y. Mi, S. R. Zhang, Q. Meng et al., Long Noncoding RNA UCA1 Targets miR-122 to Promote Proliferation, Migration, and Invasion of Glioma Cells, Oncol. Res, vol.26, pp.103-110, 2018.

I. Iino, H. Kikuchi, S. Miyazaki, Y. Hiramatsu, M. Ohta et al., Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis, Cancer Sci, vol.104, pp.624-630, 2013.

Y. Zhang, Y. Liu, and X. Xu, Knockdown of LncRNA-UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA-125a/hexokinase 2 pathway, J. Cell. Biochem, vol.119, pp.6296-6308, 2018.

Z. Tong, N. Liu, L. Lin, X. Guo, D. Yang et al., miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1, Biomed. Pharmacother, vol.75, pp.129-136, 2015.

M. D. Sun, Y. Q. Zheng, L. P. Wang, H. T. Zhao, and S. Yang, Long noncoding RNA UCA1 promotes cell proliferation, migration and invasion of human leukemia cells via sponging miR-126, Eur. Rev. Med. Pharmacol. Sci, vol.22, pp.2233-2245, 2018.

Q. Liu, Y. Li, W. Lv, G. Zhang, X. Tian et al., UCA1 promotes cell proliferation and invasion and inhibits apoptosis through regulation of the miR129-SOX4 pathway in renal cell carcinoma, OncoTargets Ther, vol.11, pp.2475-2487, 2018.

A. Fesler, H. Zhai, and J. Ju, miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer, OncoTargets Ther, vol.7, pp.1481-1485, 2014.

M. Karaayvaz, H. Zhai, and J. Ju, miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer, Cell Death Dis, vol.6, 0193.

J. Lin, Z. Shi, Z. Yu, and Z. He, LncRNA HIF1A-AS2 positively affects the progression and EMT formation of colorectal cancer through regulating miR-129-5p and DNMT3A, Biomed. Pharmacother, vol.98, pp.433-439, 2018.

J. Wu, J. Qian, C. Li, L. Kwok, F. Cheng et al., miR-129 regulates cell proliferation by downregulating Cdk6 expression, Cell Cycle, vol.9, pp.1809-1818, 2010.

N. Wu, A. Fesler, H. Liu, and J. Ju, Development of novel miR-129 mimics with enhanced efficacy to eliminate chemoresistant colon cancer stem cells, Oncotarget, vol.9, pp.8887-8897, 2017.

G. Ya, H. Wang, Y. Ma, A. Hu, J. Hu et al., Serum miR-129 functions as a biomarker for colorectal cancer by targeting estrogen receptor (ER) beta, Pharmazie, vol.72, pp.107-112, 2017.

J. Wang, C. Ye, J. Liu, and Y. Hu, UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis, Biochem. Biophys. Res. Commun, vol.501, pp.1034-1040, 2018.

R. Nagel, C. Le-sage, B. Diosdado, M. Van-der-waal, J. A. Oude-vrielink et al., Regulation of the Adenomatous Polyposis Coli Gene by the miR-135 Family in Colorectal Cancer, Cancer Res, vol.68, pp.5795-5802, 2008.

Y. Wang, Z. Hou, and D. Li, Long noncoding RNA UCA1 promotes anaplastic thyroid cancer cell proliferation via miR-135a mediated cMYC activation, Mol. Med. Rep, vol.18, pp.3068-3076, 2018.

A. Ahmad, S. E. Gomes, D. M. Pereira, C. Roma-rodrigues, A. R. Fernandes et al., Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells, PLoS ONE, vol.13, 2018.

Y. Tuo, X. Li, and J. Luo, Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143, Eur. Rev. Med. Pharm. Sci, vol.19, pp.3403-3411, 2015.

S. Tian, W. Zhao, D. Yang, Y. Yu, J. Zou et al., Atorvastatin inhibits miR-143 expression: A protective mechanism against oxidative stress in cardiomyocytes, Int. J. Cardiol, vol.211, pp.115-118, 2016.

J. Luo, J. Chen, H. Li, Y. Yang, H. Yun et al., LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR-143/HMGB1 pathway, Oncol. Lett, vol.14, pp.5556-5562, 2017.

D. Li, H. Li, Y. Yang, and L. Kang, Long Noncoding RNA Urothelial Carcinoma Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144, Oncol. Res, vol.26, pp.537-546, 2018.

T. Iwaya, T. Yokobori, N. Nishida, R. Kogo, T. Sudo et al., Downregulation of miR-144 is associated with colorectal cancer progression via activation of mTOR signaling pathway, Carcinogenesis, vol.33, pp.2391-2397, 2012.

M. Xue, H. Pang, X. Li, H. Li, J. Pan et al., Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway, Cancer Sci, vol.107, pp.18-27, 2016.

N. Sheng, G. Tan, W. You, H. Chen, J. Gong et al., MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway, vol.6, pp.1331-1340, 2017.

F. Yuan, R. Sun, L. Li, B. Jin, Y. Wang et al., A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer, Sci. Rep, vol.6, 2016.

W. Wang, G. Ji, X. Xiao, X. Chen, W. W. Qin et al., Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1, Oncotarget, vol.7, pp.68674-68687, 2016.

S. Li, X. Wu, Y. Xu, S. Wu, Z. Li et al., miR-145 suppresses colorectal cancer cell migration and invasion by targeting an ETS-related gene, Oncol. Rep, vol.36, pp.1917-1926, 2016.

Z. He, Y. Wang, G. Huang, Q. Wang, D. Zhao et al., The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP, Arch. Biochem. Biophys, pp.1-8, 2017.

Y. U. Zhang, X. Wang, Z. Wang, H. U. Tang, H. Fan et al., miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer, Oncol. Rep, vol.33, pp.2592-2598, 2015.

Z. He, C. You, and D. Zhao, Long non-coding RNA UCA1/miR-182/PFKFB2 axis modulates glioblastoma-associated stromal cells-mediated glycolysis and invasion of glioma cells, Biochem. Biophys. Res. Commun, vol.500, pp.569-576, 2018.

L. Qin, Z. Jia, D. Xie, and Z. Liu, Knockdown of long noncoding RNA urothelial carcinoma-associated 1 inhibits cell viability, migration, and invasion by regulating microRNA-182 in gastric carcinoma, J. Cell Biochem, 2018.

Z. Fang, J. Zhao, W. Xie, Q. Sun, H. Wang et al., LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by surpressing miR-184 expression, vol.6, pp.2897-2908, 2017.

G. Wu, J. Liu, Z. Wu, X. Wu, and X. Yao, MicroRNA-184 inhibits cell proliferation and metastasis in human colorectal cancer by directly targeting IGF-1R, Oncol. Lett, vol.14, pp.3215-3222, 2017.

Y. Zhou, X. Wang, J. Zhang, A. He, Y. L. Wang et al., Artesunate suppresses the viability and mobility of prostate cancer cells through UCA1, the sponge of miR-184, Oncotarget, vol.8, pp.18260-18270, 2017.

H. Wu and C. Zhou, Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis, Biochem. Biophys. Res. Commun, vol.496, pp.738-745, 2018.

P. Zhang, D. B. Ji, H. B. Han, Y. F. Shi, C. Z. Du et al., Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer, World J. Gastroenterol, vol.20, pp.12241-12248, 2014.

H. Takahashi, M. Takahashi, S. Ohnuma, M. Unno, Y. Yoshino et al., microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer, BMC Cancer, vol.17, 2017.

J. Pekow, K. Meckel, U. Dougherty, Y. Huang, X. Chen et al., miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD, Clin. Cancer Res, vol.23, pp.5281-5291, 2017.

A. Mamoori, R. Wahab, F. Islam, K. Lee, J. Vider et al., Clinical and biological significance of miR-193a-3p targeted KRAS in colorectal cancer pathogenesis, Hum. Pathol, vol.71, pp.145-156, 2018.

M. Lin, B. Duan, J. Hu, H. Yu, H. Sheng et al., Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer, Oncol. Lett, vol.14, pp.1061-1067, 2017.

W. Nie, H. J. Ge, X. Q. Yang, X. Sun, H. Huang et al., LncRNA-UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p, Cancer Lett, vol.371, pp.99-106, 2016.

H. Li, X. Sun, Z. Li, Q. Yin, H. Pang et al., LncRNA UCA1 Promotes Mitochondrial Function of Bladder Cancer via the MiR-195/ARL2 Signaling Pathway, Cell. Physiol. Biochem, vol.43, pp.2548-2561, 2017.

L. Zheng, J. Chen, and Z. Zhou, He, Z. miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1. OncoTargets Ther, vol.10, pp.1027-1038, 2017.

X. Zhang, J. Xu, T. Jiang, G. Liu, D. Wang et al., MicroRNA-195 suppresses colorectal cancer cells proliferation via targeting FGF2 and regulating Wnt/beta-catenin pathway, Am. J. Cancer Res, vol.6, pp.2631-2640, 2016.

S. Ye, W. Song, X. Xu, X. Zhao, and L. Yang, IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF-1 degradation by miR-195, FEBS Lett, vol.590, pp.1641-1650, 2016.

I. P. Yang, H. L. Tsai, Z. F. Miao, C. W. Huang, C. H. Kuo et al., Development of a deregulating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients, J. Transl. Med, vol.14, 2016.

B. Yang, Z. Tan, and Y. Song, Study on the molecular regulatory mechanism of MicroRNA-195 in the invasion and metastasis of colorectal carcinoma, Int. J. Clin. Exp. Med, vol.8, pp.3793-3800, 2015.

M. Sun, H. Song, S. Wang, C. Zhang, L. Zheng et al., Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer, J. Hematol. Oncol, vol.10, 2017.

C. Kim, Y. Hong, H. Lee, H. Kang, and E. K. Lee, MicroRNA-195 desensitizes HCT116 human colon cancer cells to 5-fluorouracil, Cancer Lett, vol.412, pp.264-271, 2018.

J. Pan, X. Li, W. Wu, M. Xue, H. Hou et al., Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells, Cancer Lett, vol.382, pp.64-76, 2016.

H. Zhang, Y. L. Su, H. Yu, and B. Y. Qian, Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility, Cancer Biol. Med, vol.9, pp.63-72, 2012.

L. Shi, C. Zhang, D. Zhao, K. Liu, T. Li et al., Mir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer, Int. J. Clin. Exp. Med, vol.8, pp.2600-2606, 2015.

J. Ge, Z. Chen, R. Li, T. Lu, and G. Xiao, Upregulation of microRNA-196a and microRNA-196b cooperatively correlate with aggressive progression and unfavorable prognosis in patients with colorectal cancer, Cancer Cell Int, vol.14, 2014.

X. Chen, P. Du, J. She, L. Cao, Y. Li et al., Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer, Oncotarget, vol.7, pp.86695-86703, 2016.

J. N. Xiao, T. H. Yan, R. M. Yu, Y. Gao, W. L. Zeng et al., Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression, J. Cancer Res. Clin. Oncol, vol.143, pp.981-990, 2017.

H. Ye, H. Hao, J. Wang, R. Chen, and Z. Huang, miR-203 as a novel biomarker for the diagnosis and prognosis of colorectal cancer: A systematic review and meta-analysis. OncoTargets Ther, vol.10, pp.3685-3696, 2017.

Q. Xu, M. Liu, J. Zhang, L. Xue, G. Zhang et al., Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway, Oncotarget, vol.7, pp.60290-60302, 2016.

Y. Takano, T. Masuda, H. Iinuma, R. Yamaguchi, K. Sato et al., Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer, Oncotarget, vol.8, pp.78598-78613, 2017.

B. Shen, Y. Yuan, Y. Zhang, S. Yu, W. Peng et al., Long non-coding RNA FBXL19-AS1 plays oncogenic role in colorectal cancer by sponging miR-203, Biochem. Biophys. Res. Commun, vol.488, pp.67-73, 2017.

T. P. Kingham, H. C. Nguyen, J. Zheng, I. T. Konstantinidis, E. Sadot et al., MicroRNA-203 predicts human survival after resection of colorectal liver metastasis, Oncotarget, vol.8, pp.18821-18831, 2017.

Q. Fu, J. Zhang, X. Xu, F. Qian, K. Feng et al., miR-203 is a predictive biomarker for colorectal cancer and its expression is associated with BIRC5, Tumour Biol, 2016.

Y. Yin, B. Zhang, W. Wang, B. Fei, C. Quan et al., miR-204-5p inhibits proliferation and invasion and enhances chemotherapeutic sensitivity of colorectal cancer cells by downregulating RAB22A, Clin. Cancer Res, vol.20, pp.6187-6199, 2014.

H. Wu, Y. Liang, and L. Shen, MicroRNA-204 modulates colorectal cancer cell sensitivity in response to 5-fluorouracil-based treatment by targeting high mobility group protein A2, Biol. Open, vol.5, pp.563-570, 2016.

A. T. Sumbul, B. Gogebakan, S. Ergun, E. Yengil, C. Y. Batmaci et al., miR-204-5p expression in colorectal cancer: An autophagy-associated gene, Tumour Biol, vol.35, pp.12713-12719, 2014.

F. Shuai, B. Wang, and S. Dong, microRNA-204 inhibits the growth and motility of colorectal cancer cells by downregulation of CXCL8, Oncol. Res, vol.5, pp.1295-1305, 2018.

G. Wang, X. Bu, Y. Zhang, X. Zhao, Y. Kong et al., LncRNA-UCA1 enhances MMP-13 expression by inhibiting miR-204-5p in human chondrocytes, Oncotarget, vol.8, pp.91281-91290, 2017.

X. Wang, B. Yang, and B. Ma, The UCA1/miR-204/Sirt1 axis modulates docetaxel sensitivity of prostate cancer cells, Cancer Chemother. Pharmacol, vol.78, pp.1025-1031, 2016.

C. Jiao, Z. Song, J. Chen, J. Zhong, W. Cai et al., lncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer, Oncol. Rep, vol.36, pp.2960-2966, 2016.

D. Li, C. Cui, J. Chen, Z. Hu, Y. Wang et al., Long noncoding RNA UCA1 promotes papillary thyroid cancer cell proliferation via miR204mediated BRD4 activation, Mol. Med. Rep, vol.18, pp.3059-3067, 2018.

Q. Yan, Y. Tian, and F. Hao, Downregulation of lncRNA UCA1 inhibits proliferation and invasion of cervical cancer cells through miR-206 expression, Oncol. Res, 2018.

F. Wang, H. Q. Ying, B. S. He, Y. Q. Pan, Q. W. Deng et al., Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway, Oncotarget, vol.6, pp.7899-7917, 2015.

X. Chen, X. Liu, B. He, Y. Pan, H. Sun et al., MiR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer, Am. J. Cancer Res, vol.7, pp.2051-2069, 2017.

S. Y. Kim, Y. H. Lee, and Y. S. Bae, MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells, Biochem. Biophys. Res. Commun, vol.429, pp.173-179, 2012.

Y. Yao, Q. Li, and H. Wang, MiR-216b suppresses colorectal cancer proliferation, migration, and invasion by targeting SRPK1, OncoTargets Ther, vol.11, pp.1671-1681, 2018.

J. Zou, W. Kuang, J. Hu, and H. Rao, miR-216b promotes cell growth and enhances chemosensitivity of colorectal cancer by suppressing PDZ-binding kinase, Biochem. Biophys. Res. Commun, vol.488, pp.247-252, 2017.

G. Zhu, X. Liu, Y. Su, F. Kong, X. Hong et al., Knockdown of urothelial carcinoma associated 1 suppressed cell growth and migration through regulating miR-301a and CXCR4 in osteosarcoma MHCC97 cells, Oncol. Res, 2018.

Y. Fang, B. Sun, J. Xiang, and Z. Chen, MiR-301a promotes colorectal cancer cell growth and invasion by directly targeting SOCS6, Cell Physiol. Biochem, vol.35, pp.227-236, 2015.

X. Ma, F. Yan, Q. Deng, F. Li, Z. Lu et al., Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer

W. Zhang, T. Zhang, R. Jin, H. Zhao, J. Hu et al., MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer, J. Exp. Clin. Cancer Res, vol.33, 2014.

Y. Yang, Y. Jiang, Y. Wan, L. Zhang, J. Qiu et al., UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis, Tumour Biol, vol.37, pp.10633-10641, 2016.

Y. Lu, W. Liu, J. Lu, Z. J. Liu, H. Li et al., LncRNA UCA1 promotes renal cell carcinoma proliferation through epigenetically repressing p21 expression and negatively regulating miR-495

Z. Bai, J. Wang, T. Wang, Y. Li, X. Zhao et al., The MiR-495/Annexin A3/P53 Axis Inhibits the Invasion and EMT of Colorectal Cancer Cells, Cell Physiol. Biochem, vol.44, pp.1882-1895, 2017.

A. Y. Chuang, J. C. Chuang, Z. Zhai, F. Wu, and J. Kwon, NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells, Inflamm. Bowel Dis, vol.20, pp.126-135, 2014.

L. Yan, J. Yao, and J. Qiu, miRNA-495 suppresses proliferation and migration of colorectal cancer cells by targeting FAM83D, Biomed. Pharmacother, vol.96, pp.974-981, 2017.

S. Guo, P. Yang, X. Jiang, X. Li, Y. Wang et al., Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression, Oncotarget, vol.8, pp.644-657, 2017.

Z. Chen, S. Liu, L. Tian, M. Wu, F. Ai et al., A. miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1, Oncotarget, vol.6, pp.38139-38150, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01789108

P. Krawczyk, T. Powrozek, T. Olesinski, A. Dmitruk, J. Dziwota et al., Evaluation of miR-506 and miR-4316 expression in early and non-invasive diagnosis of colorectal cancer, Int. J. Colorectal Dis, vol.32, pp.1057-1060, 2017.

J. L. Tong, C. P. Zhang, F. Nie, X. T. Xu, M. M. Zhu et al., MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells, FEBS Lett, vol.585, pp.3560-3568, 2011.

M. Wu, Y. Zhang, A. Tang, and L. Tian, miR-506 inhibits cell proliferation and invasion by targeting TET family in colorectal cancer, Iran J. Basic Med. Sci, vol.19, pp.316-322, 2016.

Y. Zhang, C. Lin, G. Liao, S. Liu, J. Ding et al., MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2, Oncotarget, vol.6, pp.32586-32601, 2015.

H. Zhou, C. Lin, Y. Zhang, X. Zhang, C. Zhang et al., Ren, Z. miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression, Cell Prolif, vol.50, 2017.

C. Zu, T. Liu, and G. Zhang, MicroRNA-506 Inhibits Malignancy of Colorectal Carcinoma Cells by Targeting LAMC1, Ann. Clin. Lab. Sci, vol.46, pp.666-674, 2016.

Y. Wei, Q. Sun, L. Zhao, J. Wu, X. Chen et al., LncRNA UCA1-miR-507-FOXM1 axis is involved in cell proliferation, invasion and G0/G1 cell cycle arrest in melanoma, Med. Oncol, vol.33, 2016.

L. Gu, L. Lu, D. Zhou, and Z. Liu, UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR-590-3p, Cancer Med, 2018.

C. W. Kim, E. T. Oh, J. M. Kim, J. S. Park, D. H. Lee et al., Hypoxia-induced microRNA-590-5p promotes colorectal cancer progression by modulating matrix metalloproteinase activity, Cancer Lett, vol.416, pp.31-41, 2018.

C. Ou, Z. Sun, X. Li, W. Ren, Z. Qin et al., MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer, Cancer Lett, vol.399, pp.53-63, 2017.

Z. Q. Sun, K. Shi, Q. B. Zhou, X. Y. Zeng, J. Liu et al., MiR-590-3p promotes proliferation and metastasis of colorectal cancer via Hippo pathway, Oncotarget, vol.8, pp.58061-58071, 2017.

Q. Zhou, Y. Zhu, X. Wei, J. Zhou, L. Chang et al., MiR-590-5p inhibits colorectal cancer angiogenesis and metastasis by regulating nuclear factor 90/vascular endothelial growth factor A axis, Cell Death Dis, 2016.

S. Alvarez-diaz, N. Valle, G. Ferrer-mayorga, L. Lombardia, M. Herrera et al., MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells, Hum. Mol. Genet, vol.21, pp.2157-2165, 2012.

B. Li, Y. Song, T. J. Liu, Y. B. Cui, Y. Jiang et al., miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9, Oncol. Rep, vol.29, pp.1932-1938, 2013.

B. Li, H. Sun, and H. Zhang, The predicted target gene validation, function, and prognosis studies of miRNA-22 in colorectal cancer tissue, Tumour Biol, 2017.

J. Li, Y. Zhang, J. Zhao, F. Kong, and Y. Chen, Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells, Mol. Cell. Biochem, vol.357, pp.31-38, 2011.

Y. Liu, X. Chen, R. Cheng, F. Yang, M. Yu et al., The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer, Mol. Cancer, vol.17, 2018.

Y. Tang, X. Liu, B. Su, Z. Zhang, X. Zeng et al., microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer, Mol. Med. Rep, vol.11, pp.454-460, 2015.

N. Tsuchiya, M. Izumiya, H. Ogata-kawata, K. Okamoto, Y. Fujiwara et al., Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21, Cancer Res, vol.71, pp.4628-4639, 2011.

S. S. Xia, G. J. Zhang, Z. L. Liu, H. P. Tian, Y. He et al., MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop, Oncotarget, vol.8, pp.36266-36278, 2017.

M. Yamakuchi, S. Yagi, T. Ito, and C. J. Lowenstein, MicroRNA-22 regulates hypoxia signaling in colon cancer cells, PLoS ONE, vol.6, 2011.

F. Yang, Y. Hu, H. X. Liu, and Y. J. Wan, MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor, J. Biol. Chem, vol.290, pp.6507-6515, 2015.

G. Zhang, S. Xia, H. Tian, Z. Liu, and T. Zhou, Clinical significance of miR-22 expression in patients with colorectal cancer, Med. Oncol, vol.29, pp.3108-3112, 2012.

H. Zhang, J. Tang, C. Li, J. Kong, J. Wang et al., MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells, Cancer Lett, vol.356, pp.781-790, 2015.

S. Jahid, J. Sun, R. A. Edwards, D. Dizon, N. C. Panarelli et al., miR-23a promotes the transition from indolent to invasive colorectal cancer, Cancer Discov, vol.2, pp.540-553, 2012.

X. Li, D. Liao, X. Wang, Z. Wu, J. Nie et al., Elevated microRNA-23a Expression Enhances the Chemoresistance of Colorectal Cancer Cells with Microsatellite Instability to 5-Fluorouracil by Directly Targeting ABCF1, Curr. Protein Pept. Sci, vol.16, pp.301-309, 2015.

J. Shang, F. Yang, Y. Wang, G. Xue, Q. Mei et al., MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells, J. Cell. Biochem, vol.115, pp.772-784, 2014.

H. L. Tang, M. Deng, Q. J. Liao, X. Zeng, X. T. Zhou et al., Expression and clinical significance of miR-23a and metastasis suppressor 1 in colon carcinoma, Zhonghua Bing Li Xue Za Zhi, vol.41, pp.28-32, 2012.

Z. Wang, W. Wei, and F. H. Sarkar, miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer, Cancer Discov, vol.2, pp.489-491, 2012.

F. L. Yong, C. W. Law, and C. W. Wang, Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer, BMC Cancer, vol.13, 2013.

F. L. Yong, C. W. Wang, A. C. Roslani, and C. W. Law, The involvement of miR-23a/APAF1 regulation axis in colorectal cancer, Int. J. Mol. Sci, vol.15, pp.11713-11729, 2014.

B. Chen, Y. Liu, X. Jin, W. Lu, J. Liu et al., MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells, BMC Cancer, vol.14, pp.1471-2407, 2014.

X. Fu, Z. Meng, W. Liang, Y. Tian, X. Wang et al., miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis, Oncogene, vol.33, pp.4296-4306, 2014.

R. Ghanbari, N. Mosakhani, J. Asadi, N. Nouraee, S. J. Mowla et al., Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma, Iran J. Cancer Prev, vol.8, p.22, 2015.

R. Ghanbari, S. Rezasoltani, J. Hashemi, A. Mohamadkhani, A. Tahmasebifar et al., Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients, Arch. Iran Med, vol.20, pp.92-95, 2017.

H. Konishi, M. Fujiya, N. Ueno, K. Moriichi, J. Sasajima et al., microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA, Biochem. Biophys. Res. Commun, vol.467, pp.847-852, 2015.

Y. Li, Z. Sun, B. Liu, Y. Shan, L. Zhao et al., Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer, Cell Death Dis, vol.8, p.281, 2017.

E. Lopez-urrutia, J. Coronel-hernandez, V. Garcia-castillo, C. Contreras-romero, A. Martinez-gutierrez et al., MiR-26a downregulates retinoblastoma in colorectal cancer, Tumour Biol, 2017.

H. Q. Ying, H. X. Peng, B. S. He, Y. Q. Pan, F. Wang et al., MiR-608, pre-miR-124-1 and pre-miR26a-1 polymorphisms modify susceptibility and recurrence-free survival in surgically resected CRC individuals, Oncotarget, vol.7, pp.75865-75873, 2016.

L. R. Zeitels, A. Acharya, G. Shi, D. Chivukula, R. R. Chivukula et al., Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis, Genes Dev, vol.28, pp.2585-2590, 2014.

A. Fasihi, B. Soltani, A. Atashi, and S. Nasiri, Introduction of hsa-miR-103a and hsa-miR-1827 and hsa-miR-137 as new regulators of Wnt signaling pathway and their relation to colorectal carcinoma, J. Cell. Biochem, vol.119, pp.5104-5117, 2017.

H. Y. Chen, Y. M. Lin, H. C. Chung, Y. D. Lang, C. J. Lin et al., promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4, Cancer Res, vol.72, pp.3631-3641, 2012.

F. Liu, S. Liu, F. Ai, D. Zhang, Z. Xiao et al., miR-107 Promotes Proliferation and Inhibits Apoptosis of Colon Cancer Cells by Targeting Prostate Apoptosis Response-4 (Par4), Oncol. Res, vol.25, pp.967-974, 2017.

S. Molina-pinelo, A. Carnero, F. Rivera, P. Estevez-garcia, J. M. Bozada et al., MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer, BMC Cancer, vol.14, pp.1471-2407, 2014.

G. Deng, S. Kakar, and Y. S. Kim, MicroRNA-124a and microRNA-34b/c are frequently methylated in all histological types of colorectal cancer and polyps, and in the adjacent normal mucosa, Oncol. Lett, vol.2, pp.175-180, 2011.

X. R. Gao, H. P. Wang, S. L. Zhang, M. X. Wang, and Z. S. Zhu, Pri-miR-124 rs531564 polymorphism and colorectal cancer risk, Sci. Rep, vol.5, 2015.

T. Jinushi, Y. Shibayama, I. Kinoshita, S. Oizumi, M. Jinushi et al., Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4, Cancer Med, vol.3, pp.1544-1552, 2014.

S. M. Lin, Q. Xia, Y. Q. Zhang, A. M. Sun, Y. S. Shi et al., miR-124 regulates radiosensitivity of colorectal cancer cells by targeting PRRX1. Nan Fang Yi Ke Da Xue Xue Bao, vol.36, pp.1110-1116, 2016.

K. Liu, W. Chen, S. Lei, L. Xiong, H. Zhao et al., Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line

K. Liu, H. Yao, S. Lei, L. Xiong, H. Qi et al., The miR-124-p63 feedback loop modulates colorectal cancer growth, Oncotarget, vol.8, pp.29101-29115, 2017.

K. Liu, H. Zhao, H. Yao, S. Lei, Z. Lei et al., MicroRNA-124 regulates the proliferation of colorectal cancer cells by targeting iASPP, Biomed. Res. Int, vol.867537, 2013.

S. Y. Park, H. Kim, S. Yoon, J. A. Bae, S. Y. Choi et al., KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis, Mol. Ther, vol.22, pp.1653-1664, 2014.

Y. Sun, X. Zhao, M. Luo, Y. Zhou, W. Ren et al., The pro-apoptotic role of the regulatory feedback loop between miR-124 and PKM1/HNF4alpha in colorectal cancer cells, Int. J. Mol. Sci, vol.15, pp.4318-4332, 2014.

Y. Sun, X. Zhao, Y. Zhou, and Y. Hu, miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect, Oncol. Rep, vol.28, pp.1346-1352, 2012.

K. Taniguchi, N. Sugito, M. Kumazaki, H. Shinohara, N. Yamada et al., Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells, Biochim. Biophys. Acta, vol.1852, 1971.

K. Taniguchi, N. Sugito, M. Kumazaki, H. Shinohara, N. Yamada et al., MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer, Cancer Lett, vol.363, pp.17-27, 2015.

Y. Ueda, T. Ando, S. Nanjo, T. Ushijima, and T. Sugiyama, DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis, Dig. Dis. Sci, vol.59, pp.2444-2451, 2014.

M. J. Wang, Y. Li, R. Wang, C. Wang, Y. Y. Yu et al., Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer, Int. J. Color. Dis, vol.28, pp.183-189, 2013.

Z. W. Xi, S. Y. Xin, L. Q. Zhou, H. X. Yuan, Q. Wang et al., Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer, World J. Gastroenterol, vol.21, pp.5454-5464, 2015.

J. Zhang, Y. Lu, X. Yue, H. Li, X. Luo et al., MiR-124 suppresses growth of human colorectal cancer by inhibiting STAT3, PLoS ONE, vol.8, 2013.

L. Zhou, Z. Xu, X. Ren, K. Chen, and S. Xin, MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1), Cell Physiol. Biochem, vol.38, pp.1785-1795, 2016.

I. Cristobal, B. Torrejon, P. Gonzalez-alonso, R. Manso, F. Rojo et al., Downregulation of miR-138 as a Contributing Mechanism to Lcn-2 Overexpression in Colorectal Cancer with Liver Metastasis, World J. Surg, vol.40, pp.1021-1022, 2016.

L. Long, G. Huang, H. Zhu, Y. Guo, Y. Liu et al., Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2, J. Transl. Med, vol.11, pp.1479-5876, 2013.

L. Pang, B. Li, B. Zheng, L. Niu, and L. Ge, miR-138 inhibits gastric cancer growth by suppressing SOX4, Oncol. Rep, vol.38, pp.1295-1302, 2017.

Q. Yang, X. Wang, C. Tang, X. Chen, and J. He, H19 promotes the migration and invasion of colon cancer by sponging miR-138 to upregulate the expression of HMGA1, Int. J. Oncol, 2017.

X. L. Zhang, L. L. Xu, and F. Wang, Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1, Cell Biol. Int, vol.41, pp.1056-1064, 2017.

L. Zhao, H. Yu, S. Yi, X. Peng, P. Su et al., The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer, Oncotarget, vol.7, pp.45370-45384, 2016.

K. S. Chandrasekaran, A. Sathyanarayanan, and D. Karunagaran, MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells, Br. J. Cancer, vol.115, pp.741-751, 2016.

I. Cristobal, C. Carames, J. Madoz-gurpide, F. Rojo, O. Aguilera et al., Downregulation of miR-214 is specific of liver metastasis in colorectal cancer and could play a role determining the metastatic niche, Int. J. Color. Dis, vol.29, 2014.

G. Y. He, J. L. Hu, L. Zhou, X. H. Zhu, S. N. Xin et al., The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer, Br. J. Cancer, vol.115, pp.1367-1378, 2016.

J. L. Hu, G. Y. He, X. L. Lan, Z. C. Zeng, J. Guan et al., Inhibition of ATG12-mediated autophagy by miR-214 enhances radiosensitivity in colorectal cancer, Oncogenesis, vol.7, p.16, 2018.

Y. Zhou and L. Hong, Prediction value of miR-483 and miR-214 in prognosis and multidrug resistance of esophageal squamous cell carcinoma, Genet. Test. Mol. Biomarkers, vol.17, pp.470-474, 2013.

J. Chai, D. Guo, W. Ma, D. Han, W. Dong et al., A feedback loop consisting of RUNX2/LncRNA-PVT1/miR-455 is involved in the progression of colorectal cancer, Am. J. Cancer Res, vol.8, pp.538-550, 2018.

J. Chai, S. Wang, D. Han, W. Dong, C. Xie et al., MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase, Tumour Biol, vol.36, pp.1313-1321, 2015.

Q. D. Mao, W. Zhang, K. Zhao, B. Cao, H. Yuan et al., MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer. Braz, J. Med. Biol. Res, vol.50, 2017.

H. Yunqi, Y. Fangrui, Y. Yongyan, J. Yunjian, Z. Wenhui et al., MiR-455 functions as a tumor suppressor through targeting GATA6 in colorectal cancer, Oncol. Res, vol.3, 2018.

J. Zheng, Z. Lin, L. Zhang, and H. Chen, MicroRNA-455-3p Inhibits Tumor Cell Proliferation and Induces Apoptosis in HCT116 Human Colon Cancer Cells, Med. Sci. Monit, vol.22, pp.4431-4437, 2016.

E. C. Su, .. Chen, Y. Tien, Y. Liu, J. Ho et al., ChemiRs: A web application for microRNAs and chemicals, BMC Bioinform, vol.17, 2016.

H. Mi, X. Huang, A. Muruganujan, H. Tang, C. Mills et al., PANTHER version 11: Expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements, Nucleic Acids Res, vol.45, pp.183-189, 2017.

Y. Fan, B. Shen, M. Tan, X. Mu, Y. Qin et al., Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling, FEBS J, vol.281, pp.1750-1758, 2014.

H. Liu, G. Wang, L. Yang, J. Qu, Z. Yang et al., Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/beta-Catenin Pathway, PLoS ONE, vol.11, 2016.

Y. T. Yang, Y. F. Wang, J. Y. Lai, S. Y. Shen, F. Wang et al., Long non-coding RNA UCA1 contributes to the progression of oral squamous cell carcinoma by regulating the WNT/beta-catenin signaling pathway, Cancer Sci, vol.107, pp.1581-1589, 2016.

C. Xiao, C. H. Wu, and H. Z. Hu, LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway, Eur. Rev. Med. Pharmacol. Sci, vol.20, pp.2819-2824, 2016.

L. He, H. Zhu, S. Zhou, T. Wu, H. Wu et al., Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells, Exp. Mol. Med, vol.50, 2018.

Z. Bian, J. Zhang, M. Li, Y. Feng, S. Yao et al., Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p, vol.6, 2017.

C. Li, G. Liang, S. Yang, J. Sui, W. Yao et al., Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway, Oncotarget, vol.8, p.93476, 2017.

Y. Xu, Y. Yao, K. Leng, Z. Li, W. Qin et al., Long non-coding RNA UCA1 indicates an unfavorable prognosis and promotes tumorigenesis via regulating AKT/GSK-3beta signaling pathway in cholangiocarcinoma, Oncotarget, vol.8, pp.96203-96214, 2017.

Z. Wang, C. He, L. Hu, H. Shi, J. Li et al., Long noncoding RNA UCA1 promotes tumour metastasis by inducing GRK2 degradation in gastric cancer, Cancer Lett, vol.408, pp.10-21, 2017.

S. Zhen, L. Hua, Y. Liu, X. Sun, M. Jiang et al., Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated malignant phenotypes of bladder cancer, Oncotarget, vol.8, pp.9634-9646, 2017.

W. Zhao, C. Sun, and Z. Cui, A long noncoding RNA UCA1 promotes proliferation and predicts poor prognosis in glioma, Clin. Transl. Oncol, vol.19, pp.735-741, 2017.

X. Zhengyuan, X. Hu, W. Qiang, L. Nanxiang, C. Junbin et al., Silencing of Urothelial Carcinoma Associated 1 Inhibits the Proliferation and Migration of Medulloblastoma Cells, Med. Sci. Monit, vol.23, pp.4454-4461, 2017.

H. Pu, Q. Zheng, H. Li, M. Wu, J. An et al., CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc, Oncotarget, vol.6, pp.40775-40798, 2015.

L. Q. Li, D. Pan, Q. Chen, S. W. Zhang, D. Y. Xie et al., Sensitization of Gastric Cancer Cells to 5-FU by MicroRNA-204 Through Targeting the TGFBR2-Mediated Epithelial to Mesenchymal Transition, Cell. Physiol. Biochem, vol.47, pp.1533-1545, 2018.

S. A. Kim, I. Kim, S. K. Yoon, E. K. Lee, and H. J. Kuh, Indirect modulation of sensitivity to 5-fluorouracil by microRNA-96 in human colorectal cancer cells, Arch. Pharm. Res, vol.38, pp.239-248, 2015.

L. Shi, X. Li, Z. Wu, J. Nie, M. Guo et al., DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1, J. Genet. Genom, vol.45, pp.205-214, 2018.

B. Liu, Y. Liu, L. Zhao, Y. Pan, Y. Shan et al., Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway, Mol. Carcinog, vol.56, pp.2669-2680, 2017.

A. Pagliuca, C. Valvo, E. Fabrizi, S. Di-martino, M. Biffoni et al., Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression, Oncogene, vol.32, pp.4806-4813, 2013.

C. Feng, L. Zhang, Y. Sun, X. Li, L. Zhan et al., GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer, Biomed. Pharmacother, vol.101, pp.945-952, 2018.

Y. Jin, M. Wang, H. Hu, Q. Huang, Y. Chen et al., Overcoming stemness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling, Int. J. Biol. Macromol, vol.117, pp.445-453, 2018.

Y. Zhou, G. Wan, R. Spizzo, C. Ivan, R. Mathur et al., induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase, Mol. Oncol, vol.8, pp.83-92, 2014.

T. Li, F. Gao, and X. P. Zhang, miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer, Oncol. Rep, vol.33, pp.607-614, 2015.

Y. Liu, S. Gao, X. Chen, M. Liu, C. Mao et al., Overexpression of miR-203 sensitizes paclitaxel (Taxol)-resistant colorectal cancer cells through targeting the salt-inducible kinase 2 (SIK2), Tumour Biol, vol.37, pp.12231-12239, 2016.

X. Meng and R. Fu, miR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells, OncoTargets Ther, vol.11, pp.1757-1765, 2018.

K. W. Hon, N. Abu, N. Ab-mutalib, and R. Jamal, miRNAs and lncRNAs as Predictive Biomarkers of Response to FOLFOX Therapy in Colorectal Cancer, Front. Pharmacol, vol.9, 2018.

L. Dong, W. Lin, P. Qi, M. D. Xu, X. Wu et al., Circulating Long RNAs in Serum Extracellular Vesicles: Their Characterization and Potential Application as Biomarkers for Diagnosis of Colorectal Cancer, Cancer Epidemiol. Biomarkers Prev, vol.25, pp.1158-1166, 2016.

S. Tang, G. Tan, X. Jiang, P. Han, B. Zhai et al., An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells, Oncotarget, vol.7, pp.73257-73269, 2016.