Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States, Cancer Res, 2014. ,
, Lancet, vol.378, pp.607-620, 2011.
,
Pancreatic Cancer Chemoresistance to Gemcitabine, vol.9, 2017. ,
Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma, Cancer Cell, vol.32, pp.185-203, 2017. ,
TGF-beta: Duality of function between tumor prevention and carcinogenesis, J. Natl. Cancer Inst, vol.106, 2014. ,
TGF-beta signaling in tumor suppression and cancer progression, Nat. Genet, vol.29, pp.117-129, 2001. ,
A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis, Oncogene, vol.23, pp.5729-5738, 2004. ,
The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family, Oncogene, vol.32, pp.1714-1723, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00807837
, Cancer Res, vol.56, pp.2527-2530, 1996.
Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic, Biochim. Biophys. Acta, vol.1796, pp.75-90, 2009. ,
TGF-beta signaling in cancer-A double-edged sword, Trends Cell Biol, vol.11, pp.44-51, 2001. ,
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression, Genes Dev, vol.20, pp.3147-3160, 2006. ,
Neutralizing murine TGFbetaR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis, Cancer Res, vol.74, pp.4996-5007, 2014. ,
miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer, PLoS ONE, vol.10, 2015. ,
The miR-371 approximately 373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis, Cancer Res, vol.78, pp.3793-3808, 2018. ,
Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma, Mol. Cancer Ther, vol.16, pp.1729-1738, 2017. ,
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer, Gastroenterology, vol.149, pp.1932-1943, 2015. ,
Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation, Cancer Res, vol.68, pp.7736-7741, 2008. ,
Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer, Mol. Cancer, vol.12, 2013. ,
Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals, Cancer Res, vol.73, pp.2221-2234, 2013. ,
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group, J. Clin. Oncol, vol.25, pp.1960-1966, 2007. ,
Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer, PLoS ONE, vol.6, 2011. ,
Phenotype and genotype of pancreatic cancer cell lines, Pancreas, vol.39, pp.425-435, 2010. ,
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence, Cell Cycle, vol.16, pp.319-334, 2017. ,
TNFalpha and TGFbeta-1 synergistically increase the cancer stem cell properties of MiaPaCa-2 cells, Oncol. Lett, vol.14, pp.4647-4658, 2017. ,
Loss of TGFbeta Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance, Cancer Res, vol.75, pp.1457-1469, 2015. ,
Mechanisms of the epithelial-mesenchymal transition by TGF-beta, Future Oncol, vol.5, pp.1145-1168, 2009. ,
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling, vol.36, pp.4001-4013, 2017. ,
Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells, Biochim. Biophys. Acta, vol.1861, pp.296-306, 2017. ,
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways, PLoS ONE, vol.7, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00807830
Sequence of the 5 -flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells, Biochem. J, vol.348, pp.675-686, 2000. ,
Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines, J. Biol. Chem, vol.278, pp.51549-51556, 2003. ,
The K protein domain that recruits the interleukin 1-responsive K protein kinase lies adjacent to a cluster of c-Src and Vav SH3-binding sites. Implications that K protein acts as a docking platform, J. Biol. Chem, vol.270, pp.26976-26985, 1995. ,
Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression, Br. J. Cancer, vol.101, pp.637-644, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00410436
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha, Biochem. J, vol.402, pp.81-91, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00478670
The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells, Biochem. Biophys. Res. Commun, vol.325, pp.952-960, 2004. ,
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data, Cancer Discov, vol.2, pp.401-404, 2012. ,
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal, Sci. Signal, issue.6, 2013. ,
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, Nature, vol.483, pp.603-607, 2012. ,