Gut-Brain Glucose Signaling in Energy Homeostasis - Archive ouverte HAL Access content directly
Journal Articles Cell Metabolism Year : 2017

Gut-Brain Glucose Signaling in Energy Homeostasis

(1) , (1) , (1) , (1)


Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis. Intestinal gluconeogenesis induced by specific nutrients releases glucose, which is sensed by the nervous system surrounding the portal vein. This initiates a signal positively influencing parameters involved in glucose control and energy management controlled by the brain. This knowledge has extended our vision of the gut-brain axis, classically ascribed to gastrointestinal hormones. Our work raises several questions relating to the conditions under which intestinal gluconeogenesis proceeds and may provide its metabolic benefits. It also leads to questions on the advantage conferred by its conservation through a process of natural selection.

Dates and versions

inserm-02339600 , version 1 (30-10-2019)



Maud Soty, Amandine Gautier-Stein, Fabienne Rajas, Gilles Mithieux. Gut-Brain Glucose Signaling in Energy Homeostasis. Cell Metabolism, 2017, 25 (6), pp.1231-1242. ⟨10.1016/j.cmet.2017.04.032⟩. ⟨inserm-02339600⟩
26 View
0 Download



Gmail Facebook Twitter LinkedIn More