M. Oplatowska-stachowiak and C. T. Elliott, Food colors: Existing and emerging food safety concerns, Critical reviews in food science and nutrition, vol.57, pp.524-548, 2017.

P. Amchova, H. Kotolova, and J. Ruda-kucerova, Health safety issues of synthetic food colorants, Regulatory Toxicology and Pharmacology, vol.73, pp.914-922, 2015.

C. I. Chappel and J. C. Howell, Caramel colours-a historical introduction, Food and chemical toxicology, vol.30, pp.351-357, 1992.

L. R. Vartanian, M. B. Schwartz, and K. D. Brownell, Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis, American journal of public health, vol.97, pp.667-675, 2007.

D. Kregiel, Health safety of soft drinks: contents, containers, and microorganisms, BioMed research international, 2015.

T. J. Smith, Caramel color in soft drinks and exposure to 4-methylimidazole: a quantitative risk assessment, PloS one, vol.10, p.118138, 2015.

S. C. Cunha, L. Senra, R. Cruz, S. Casal, and J. O. Fernandes, 4-Methylimidazole in soluble coffee and coffee substitutes, Food Control, vol.63, pp.15-20, 2016.

P. Mottier, C. Mujahid, A. Tarres, T. Bessaire, and R. H. Stadler, Process-induced formation of imidazoles in selected foods, Food chemistry, vol.228, pp.381-387, 2017.

L. F. Wiggins, Some recent studies on ammoniated molasses, Sugar J, vol.18, pp.18-20, 1956.

, Toxicology and carcinogenesis studies of 4-methylimidazole (Cas No. 822-36-6) in F344/N rats and B6C3F1 mice (feed studies), National Toxicology Program technical report series, vol.535, p.1, 2007.

P. C. Chan, G. D. Hills, G. E. Kissling, and A. Nyska, Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice, Archives of toxicology, vol.82, pp.45-53, 2008.

F. Mehri, M. Faizi, A. Salimi, E. Seydi, and J. Pourahmad, Toxicity of 4-methylimidazole on isolated brain mitochondria: using both in vivo and in vitro methods, Toxicological & Environmental Chemistry, vol.97, pp.663-673, 2015.

T. Morita and C. Uneyama, Genotoxicity assessment of 4-methylimidazole: regulatory perspectives, Genes and Environment, vol.38, p.20, 2016.

M. S. Palmnäs, Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the dietinduced obese rat, PloS one, vol.9, p.109841, 2014.

J. Suez, Artificial sweeteners induce glucose intolerance by altering the gut microbiota, Nature, vol.514, p.181, 2014.

K. M. Mackenzie, Toxicity and carcinogenicity studies of Caramel Colour IV in F344 rats and B6C3F1 mice, Food and Chemical Toxicology, vol.30, pp.431-443, 1992.

A. M. Calafat and L. L. Needham, Human exposures and body burdens of endocrine-disrupting chemicals, Endocrine-DisruptingChemicals, pp.253-268, 2007.

C. M. Klinge, J. L. Bowers, P. C. Kulakosky, K. K. Kamboj, and H. I. Swanson, The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements, Molecular and cellular endocrinology, vol.157, pp.105-119, 1999.

N. Rajapakse, D. Ong, and A. Kortenkamp, Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens, Toxicological Sciences, vol.60, pp.296-304, 2001.

G. Velmurugan, Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis, Genome biology, vol.18, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-02339597

F. B. Hu and V. S. Malik, Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence, Physiology & behavior, vol.100, pp.47-54, 2010.

J. Milei, Chronic cola drinking induces metabolic and cardiac alterations in rats, World journal of cardiology, vol.3, p.111, 2011.

V. S. Malik, Sugar sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis, Diabetes care, 2010.

D. Kerr, Effect of caffeine on the recognition of and responses to hypoglycaemia in humans, Annals of internal medicine, vol.119, pp.799-804, 1993.

M. E. Patti, Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia, Diabetologia, vol.48, pp.2236-2240, 2005.

I. Finamor, Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice, Redox biology, vol.11, pp.701-707, 2017.

J. L. Kuk and R. E. Brown, Aspartame intake is associated with greater glucose intolerance in individuals with obesity, Nutrition, and Metabolism, vol.41, pp.795-798, 2016.

V. T. Samuel and G. I. Shulman, Mechanisms for insulin resistance: common threads and missing links, Cell, vol.148, pp.852-871, 2012.

Y. F. Otero, J. M. Stafford, and O. P. Mcguinness, Pathway-selective insulin resistance and metabolic disease: the importance of nutrient flux, Journal of Biological Chemistry, p.114, 2014.

N. T. Mueller, Soft drink and juice consumption and risk of pancreatic cancer: the Singapore Chinese Health Study, Cancer Epidemiology and Prevention Biomarkers, vol.19, pp.447-455, 2010.

Y. Bao, Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study, The American journal of clinical nutrition, vol.88, pp.431-440, 2008.

G. Velmurugan, Gut microbiota in toxicological risk assessment of drugs and chemicals: The need of hour, Gut microbes, pp.1-4, 2018.

J. E. Ayala, Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Disease models & mechanisms, p.6239, 2010.

M. M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical biochemistry, vol.72, pp.248-254, 1976.

H. H. Taussky and E. Shorr, A. microcolorimetric method for the determination of inorganic phosphorus, Journal of Biological Chemistry, vol.202, pp.675-685, 1953.

N. V. Carroll, R. W. Longley, and J. H. Roe, The determination of glycogen in liver and muscle by use of anthrone reagent, J biol Chem, vol.220, pp.583-593, 1956.

H. Ohkawa, N. Ohishi, and K. Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Analytical biochemistry, vol.95, pp.351-358, 1979.

A. Z. Reznick and L. Packer, Oxidative damage to proteins: spectrophotometric method for carbonyl assay, In Methods in enzymology, vol.38, pp.357-363, 1994.