Skip to Main content Skip to Navigation
Journal articles

MAIT cells in metabolic diseases

Abstract : Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites. MAIT cells can promote inflammation and are present in many organs central to metabolism, suggesting a role in the etiopathology of these diseases. SCOPE OF THE REVIEW: Here, we will review what is known of the involvement of MAIT cells in metabolic pathologies in humans and mice. MAJOR CONCLUSIONS: MAIT cells are severely affected, overactivated with a frequency reduction and a phenotype shift from protective to deleterious. Therefore, they might be a novel target to treat, in particular, pancreas and liver metabolic diseases.
Document type :
Journal articles
Complete list of metadata

Cited literature [57 references]  Display  Hide  Download
Contributor : Agnès Lehuen Connect in order to contact the contributor
Submitted on : Wednesday, October 30, 2019 - 2:32:18 PM
Last modification on : Tuesday, May 17, 2022 - 10:14:04 AM


Publication funded by an institution




Léo Bertrand, Agnès Lehuen. MAIT cells in metabolic diseases. Molecular metabolism, Elsevier, 2018, 27S, pp.S114-S121. ⟨10.1016/j.molmet.2019.06.025⟩. ⟨inserm-02339506⟩



Record views


Files downloads