A. In and . Jid, EBIOM [m5G, 2019.

, JID: EBIOM [m5G, vol.14, p.0, 2019.

L. Ricci-vitiani, D. G. Lombardi, E. Pilozzi, M. Biffoni, M. Todaro et al., Identification and expansion of human colon-cancer-initiating cells, Nature, vol.445, issue.7123, pp.111-126, 20074.

C. A. O'brien, A. Pollett, S. Gallinger, and J. E. Dick, A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature, vol.445, issue.7123, pp.106-116, 20074.

W. Gao, L. Chen, Z. Ma, Z. Du, Z. Zhao et al., Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential, Gastroenterology, vol.145, issue.3, pp.636-682, 2013.

S. Colak, C. D. Zimberlin, E. Fessler, L. Hogdal, P. R. Prasetyanti et al., Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells, Cell Death Differ, vol.21, issue.7, pp.1170-1177, 2014.

D. J. Huels and O. J. Sansom, Stem vs non-stem cell origin of colorectal cancer, Br J Cancer, vol.113, issue.1, pp.1-5, 2015.

J. P. Medema and L. Vermeulen, Microenvironmental regulation of stem cells in intestinal homeostasis and cancer, Nature, vol.474, issue.7351, pp.318-344, 2011.

L. Vermeulen, D. Sousa, E. Melo, F. Van-der-heijden, M. et al., Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, Nat Cell Biol, vol.12, issue.5, pp.468-76, 2010.

S. Colak and J. P. Medema, Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells, Cell Cycle Georget Tex, 2014.

H. Wei, R. Zeng, J. Lu, W. Lai, W. Chen et al., Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production, Oncotarget, vol.6, issue.10, pp.7713-7739, 2015.

B. D. Gulbransen and K. A. Sharkey, Novel functional roles for enteric glia in the gastrointestinal tract, Nat Rev Gastroenterol Hepatol, vol.9, issue.11, pp.625-657, 2012.

K. A. Sharkey, Emerging roles for enteric glia in gastrointestinal disorders, J Clin Invest, vol.125, issue.3, pp.918-943, 20152.

M. Neunlist, L. Van-landeghem, M. M. Mahé, P. Derkinderen, S. B. Des-varannes et al., The digestive neuronal-glial-epithelial unit: a new actor in gut health and disease, Nat Rev Gastroenterol Hepatol, vol.10, issue.2, pp.90-100, 2013.

T. G. Bush, T. C. Savidge, T. C. Freeman, H. J. Cox, E. A. Campbell et al., Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice, Cell, vol.93, issue.2, pp.189-201, 1998.

L. Van-landeghem, C. J. Mahé, M. M. Wedel, T. Urvil, P. Derkinderen et al., Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF, Am J Physiol Gastrointest Liver Physiol, vol.300, issue.6, pp.976-87, 2011.

T. C. Savidge, P. Newman, C. Pothoulakis, A. Ruhl, M. Neunlist et al., Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione, Gastroenterology, vol.132, issue.4, pp.1344-58, 2007.

M. Neunlist, A. P. Bonnaud, S. Van-landeghem, L. Coron, E. Wedel et al., Enteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway, Am J Physiol Gastrointest Liver Physiol, vol.292, issue.1, pp.231-272, 2007.

Y. A. Liu, Y. C. Chung, S. T. Pan, M. Y. Shen, Y. C. Hou et al., 3-D imaging, illustration, and quantitation of enteric glial network in transparent human colon mucosa, Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc, vol.25, issue.5, pp.324-362, 2013.

S. B. Garcia, H. Stopper, and V. Kannen, The contribution of neuronal-glial-endothelial-epithelial interactions to colon carcinogenesis, Cell Mol Life Sci, vol.71, issue.17, pp.3191-3198, 2014.

R. Soret, S. Coquenlorge, F. Cossais, G. Meurette, M. Rolli-derkinderen et al., Characterization of human, mouse, and rat cultures of enteric glial cells and their effect on intestinal epithelial cells, Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc, vol.25, issue.11, pp.755-64, 2013.

J. G. Wong-lee and M. Lovett, Rapid and sensitive PCR method for identification of Mycoplasma species in tissue culture, Diagn Mol Microbiol Princ Appl Am Soc Microbiol Wash DC USA, 1993.

T. M. Yeung, S. C. Gandhi, J. L. Wilding, R. Muschel, and W. F. Bodmer, Cancer stem cells from colorectal cancer-derived cell lines, Proc Natl Acad Sci, vol.107, issue.8, pp.3722-3729, 201023.

G. I. Botchkina, E. S. Zuniga, M. Das, Y. Wang, H. Wang et al., New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells, Mol Cancer, vol.9, p.192, 2010.

P. Dalerba, S. J. Dylla, I. Park, R. Liu, X. Wang et al., Phenotypic characterization of human colorectal cancer stem cells, Proc Natl Acad Sci U S A, vol.104, issue.24, pp.10158-63, 200712.

N. Renier, Z. Wu, D. J. Simon, J. Yang, A. P. Tessier-lavigne et al., iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging, Cell, vol.159, issue.4, pp.896-910, 2014.

B. L. Adamsen, K. L. Kravik, D. Angelis, and P. M. , DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status, Int J Oncol, vol.39, issue.3, pp.673-82, 2011.

M. Murakami, T. Ohta, K. Otsuguro, and S. Ito, Involvement of prostaglandin E2 derived from enteric glial cells in the action of bradykinin in cultured rat myenteric neurons, Neuroscience, vol.145, issue.2, pp.642-53, 2007.

P. Jung, C. Sommer, F. M. Barriga, S. J. Buczacki, X. Hernando-momblona et al., Isolation of human colon stem cells using surface expression of PTK7, Stem Cell Rep, vol.5, issue.6, pp.979-87, 2015.

M. Gemei, P. Mirabelli, D. Noto, R. Corbo, C. Iaccarino et al., CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo, Cancer, vol.119, issue.4, pp.729-767, 2013.

E. H. Huang, M. J. Hynes, T. Zhang, C. Ginestier, G. Dontu et al., Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis, Cancer Res, vol.69, issue.8, pp.3382-3391, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01431953

R. Pai, B. Soreghan, I. L. Szabo, M. Pavelka, D. Baatar et al., Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy, Nat Med, vol.8, issue.3, pp.289-93, 2002.

F. G. Buchanan, D. L. Gorden, P. Matta, Q. Shi, L. M. Matrisian et al., Role of beta-arrestin 1 in the metastatic progression of colorectal cancer, Proc Natl Acad Sci, vol.103, issue.5, pp.1492-1499, 2006.

H. Li, F. Reinhardt, H. R. Herschman, and R. A. Weinberg, Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling, Cancer Discov, vol.2, issue.9, pp.840-55, 2012.

C. A. Dinarello and S. M. Wolff, The role of interleukin-1 in disease, N Engl J Med, vol.328, issue.2, pp.106-119, 1993.

A. E. Postlethwaite, R. Raghow, G. P. Stricklin, H. Poppleton, J. M. Seyer et al., Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta, J Cell Biol, vol.106, issue.2, pp.311-329, 1988.

K. D. Mayer-barber, B. B. Andrade, S. D. Oland, E. P. Amaral, D. L. Barber et al., Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk, Nature, vol.511, issue.7507, pp.99-103, 2014.

B. Stoffels, K. J. Hupa, S. A. Snoek, S. Van-bree, K. Stein et al., Postoperative ileus involves interleukin-1 receptor signaling in enteric glia, Gastroenterology, vol.146, issue.1, pp.176-87, 2014.

B. Schwartz and E. Yehuda-shnaidman, Putative role of adipose tissue in growth and metabolism of colon cancer cells, Front Oncol, vol.4, p.164, 2014.

V. Catalano, A. Turdo, D. Franco, S. Dieli, F. Todaro et al., Tumor and its microenvironment: a synergistic interplay, Semin Cancer Biol, vol.23, pp.522-554, 2013.

F. Mariani, P. Sena, and L. Roncucci, Inflammatory pathways in the early steps of colorectal cancer development, World J Gastroenterol, vol.20, issue.29, pp.9716-9747, 2014.

M. L. Taddei, E. Giannoni, G. Comito, and P. Chiarugi, Microenvironment and tumor cell plasticity: an easy way out, Cancer Lett, vol.341, issue.1, pp.80-96, 2013.

L. Loupp, A. Bach-ngohou, K. Bourreille, A. Boudin, H. Rolli-derkinderen et al., Activation of the prostaglandin D2 metabolic pathway in Crohn's disease: involvement of the enteric nervous system, BMC Gastroenterol, vol.15, p.112, 2015.

C. Pochard, S. Coquenlorge, J. Jaulin, N. Cenac, N. Vergnolle et al., Defects in 15-HETE production and control of epithelial permeability by human enteric glial cells from patients with crohn's disease, Gastroenterology, vol.150, issue.1, pp.168-80, 2016.

A. In and . Jid, EBIOM [m5G, 2019.

S. Coquenlorge, L. Van-landeghem, J. Jaulin, N. Cenac, N. Vergnolle et al., The arachidonic acid metabolite 11?-ProstaglandinF2? controls intestinal epithelial healing: deficiency in patients with Crohn's disease, Sci Rep, vol.6, p.25203, 2016.

K. Bach-ngohou, M. M. Mahé, P. Aubert, H. Abdo, S. Boni et al., Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2, J Physiol, vol.588, pp.2533-2577, 2010.

M. D. Guerrero, M. Aquino, I. Bruno, M. C. Terencio, M. Paya et al., Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression, J Med Chem, vol.50, issue.9, pp.2176-84, 2007.

E. Mansouri, F. E. Nebbaki, S. Kapoor, M. Afif, H. Martel-pelletier et al., Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1?-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes, Arthritis Res Ther, vol.16, issue.3, p.113, 2014.

N. Zayed, E. Mansouri, F. E. Chabane, N. Kapoor, M. Martel-pelletier et al., Valproic acid suppresses interleukin-1ß-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1, J Rheumatol, vol.38, issue.3, pp.492-502, 2011.

K. Deckmann, F. Rörsch, R. Steri, M. Schubert-zsilavecz, G. Geisslinger et al., Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-?B, Biochem Pharmacol, vol.80, issue.9, pp.1365-72, 2010.

D. Wang, L. Fu, H. Sun, L. Guo, and R. N. Dubois, Prostaglandin E2 promotes colorectal cancer stem cell expansion and metastasis in mice, Gastroenterology, vol.149, issue.7, pp.1884-95, 2015.

G. A. Doherty, S. M. Byrne, E. S. Molloy, V. Malhotra, S. C. Austin et al., Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer, BMC Cancer, vol.9, p.207, 2009.

G. Rademakers, N. Vaes, S. Schonkeren, A. Koch, K. A. Sharkey et al., The role of enteric neurons in the development and progression of colorectal cancer, Biochim Biophys Acta, 2017.

E. Duchalais, C. Guilluy, S. Nedellec, M. Touvron, A. Bessard et al., Colorectal cancer cells adhere to and migrate along the neurons of the enteric nervous system, Cell Mol Gastroenterol Hepatol, vol.5, issue.1, pp.31-49, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01718258

M. Pesic and F. R. Greten, Inflammation and cancer: tissue regeneration gone awry, Curr Opin Cell Biol, vol.43, pp.55-61, 2016.

A. M. Soto and C. Sonnenschein, The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory, BioEssays News Rev Mol Cell Dev Biol, vol.33, issue.5, pp.332-372, 2011.

Z. Hou, D. J. Falcone, K. Subbaramaiah, and A. J. Dannenberg, Macrophages induce COX-2 expression in breast cancer cells: role of IL-1? autoamplification, Carcinogenesis, vol.32, issue.5, pp.695-702, 2011.

J. Dudás, A. Fullár, M. Bitsche, V. Schartinger, I. Kovalszky et al., Tumor-produced, active interleukin-1 ? regulates gene expression in carcinoma-associated fibroblasts, Exp Cell Res, vol.317, issue.15, pp.2222-2231, 2011.

T. Wu, Y. Hong, L. Jia, J. Wu, J. Xia et al., Modulation of IL-1? reprogrammes the tumor microenvironment to interrupt oral carcinogenesis, Sci Rep, vol.6, p.20208, 2016.