The genetics of the E2F family of transcription factors: shared functions and unique roles, Biochim Biophys Acta, vol.1602, issue.2, pp.131-50, 2002. ,
The regulation of E2F by pRB-family proteins, Genes Dev, vol.12, issue.15, pp.2245-62, 1998. ,
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes, Embo J, vol.22, issue.23, pp.6289-98, 2003. ,
The Rb/E2F pathway: expanding roles and emerging paradigms, Genes Dev, vol.14, pp.2393-409, 2000. ,
Distinct roles for E2F proteins in cell growth control and apoptosis, Proc Natl Acad Sci U S A, vol.94, issue.14, pp.7245-50, 1997. ,
Expression of transcription factor E2F1 induces quiescent cells to enter S phase, Nature, vol.365, issue.6444, pp.349-52, 1993. ,
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis, Proc Natl Acad Sci, vol.91, issue.23, pp.10918-10940, 1994. ,
p53 and E2F-1 cooperate to mediate apoptosis, Proc Natl Acad Sci U S A, vol.91, issue.9, pp.3602-3608, 1994. ,
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2, Cell Growth Differ, vol.9, issue.2, pp.113-121, 1998. ,
, , pp.2-3
, functions in mice to promote apoptosis and suppress proliferation, Cell, vol.85, issue.4, pp.549-61, 1996.
A role for E2F1 in the induction of apoptosis during thymic negative selection, Cell Growth Differ, vol.11, issue.2, pp.91-99, 2000. ,
Tumor induction and tissue atrophy in mice lacking E2F-1, Cell, vol.85, issue.4, pp.537-585, 1996. ,
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis, Mol Cell Biol, vol.15, issue.12, pp.6864-74, 1995. ,
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction, Genes Dev, vol.11, issue.14, pp.1840-52, 1997. ,
E2F1 pathways to apoptosis, FEBS Lett, vol.529, issue.1, pp.122-127, 2002. ,
The E2F-1 transcription factor promotes caspase-8 and bid expression, and enhances Fas signaling in T cells, J Immunol, vol.173, issue.2, pp.1111-1118, 2004. ,
,
, pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis, J Biol Chem, vol.277, issue.50, pp.48764-70, 2002.
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis, Cell, vol.66, issue.2, pp.233-276, 1991. ,
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain, J Biol Chem, vol.270, issue.14, pp.7795-7803, 1995. ,
FADD, a novel death domaincontaining protein, interacts with the death domain of Fas and initiates apoptosis, Cell, vol.81, issue.4, pp.505-517, 1995. ,
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death, Cell, vol.85, issue.6, pp.803-818, 1996. ,
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases, Proc Natl Acad Sci, vol.93, issue.25, pp.14486-91, 1996. ,
,
, FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex, Cell, vol.85, issue.6, pp.817-844, 1996.
,
, Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor, Embo J, vol.14, issue.22, pp.5579-88, 1995.
,
, FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
, Embo J, vol.16, issue.10, pp.2794-804, 1997.
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis, J Exp Med, 1998. ,
Two CD95 (APO-1/Fas) signaling pathways, Embo J, vol.17, issue.6, pp.1675-87, 1998. ,
,
a novel caspase homologue with death effector domains, J Biol Chem, vol.272, issue.32, pp.19641-19645, 1997. ,
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death, Proc Natl Acad Sci U S A, vol.94, issue.21, pp.11333-11341, 1997. ,
CLARP, a death effector domaincontaining protein interacts with caspase-8 and regulates apoptosis, Proc Natl Acad Sci U S A, vol.272, issue.28, pp.10717-10739, 1997. ,
Inhibition of death receptor signals by cellular FLIP, Nature, vol.388, issue.6638, pp.190-195, 1997. ,
Casper is a FADD-and caspase-related inducer of apoptosis, Immunity, vol.6, issue.6, pp.751-63, 1997. ,
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis, J Biol Chem, vol.272, issue.30, pp.18542-18547, 1997. ,
Cellular FLICEinhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex, J Biol Chem, vol.276, issue.23, pp.20633-20673, 2001. ,
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis, Embo J, vol.21, issue.14, pp.3704-3718, 2002. ,
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex, J Biol Chem, vol.277, issue.47, pp.45162-71, 2002. ,
Activation of caspases-8 and -10 by FLIP(L), Biochem J, vol.382, issue.2, pp.651-658, 2004. ,
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis, J Exp Med, vol.199, issue.8, pp.1041-52, 2004. ,
Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma, Oncogene, vol.20, issue.14, pp.1678-87, 2001. ,
URL : https://hal.archives-ouvertes.fr/inserm-02337591
Induction of DNA synthesis and apoptosis are separable functions of E2F-1, Genes Dev, vol.11, issue.14, pp.1853-63, 1997. ,
,
, Direct coupling of the cell cycle and cell death machinery by E2F, Nat Cell Biol, vol.4, issue.11, pp.859-64, 2002.
Betulinic acid triggers CD95 (APO-1/Fas)-and p53-independent apoptosis via activation of caspases in neuroectodermal tumors, Cancer Res, vol.57, issue.21, pp.4956-64, 1997. ,
Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L, J Cell Biol, 1998. ,
The anti-cancer drug etoposide ,
, Fas ligand-independent
, FADD-mediated activation of the Fas death pathway by anticancer drugs, J Biol Chem, vol.274, issue.12, pp.7987-92, 1999.
Molecular ordering of the initial signaling events of CD95, Mol Cell Biol, vol.22, issue.1, pp.207-227, 2002. ,
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity, Science, vol.265, issue.5171, pp.528-558, 1994. ,
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways, Nature, vol.370, issue.6491, pp.650-652, 1994. ,
Antitumor cytotoxic T-lymphocyte response in human lung carcinoma: identification of a tumorassociated antigen, Immunol Rev, vol.188, pp.114-135, 2002. ,
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors, J Exp Med, vol.190, issue.7, pp.1025-1057, 1999. ,
Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein, J Exp Med, vol.190, issue.7, pp.1033-1041, 1999. ,
Role for the p53 homologue p73 in E2F-1-induced apoptosis, Nature, vol.407, issue.6804, pp.645-653, 2000. ,
Role of the p53-homologue p73 in E2F1-induced apoptosis, Nat Genet, vol.26, issue.4, pp.464-473, 2000. ,
Apaf-1 is a transcriptional target for E2F and p53, Nat Cell Biol, vol.3, issue.6, pp.552-560, 2001. ,
Apaf-1 is a mediator of E2F-1-induced apoptosis, J Biol Chem, vol.277, issue.42, pp.39760-39768, 2002. ,
E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways, Mol Cell, vol.4, issue.5, pp.771-81, 1999. ,
Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases, Embo J, vol.18, issue.6, pp.1559-70, 1999. ,
Cleavage of E2F-1-regulating proteins and activation of E2F-1 during CD95-induced death of thymocytes, Immunology, vol.104, issue.1, pp.37-42, 2001. ,
Inhibition of fas death signals by FLIPs, Curr Opin Immunol, vol.10, issue.5, pp.552-560, 1998. ,
Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor, Oncogene, vol.18, issue.44, pp.6071-6078, 1999. ,
Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression, Cancer Res, vol.60, issue.14, pp.3947-56, 2000. ,
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors, Nature, vol.386, issue.6624, pp.517-538, 1997. ,
The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis, FEBS Lett, vol.510, issue.1-2, pp.37-40, 2002. ,
TCR-mediated upregulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity, J Immunol, vol.165, issue.11, pp.6293-300, 2000. ,
Loss of Rb-E2F repression results in caspase-8 ,
mediated apoptosis through inactivation of focal adhesion kinase, J Biol Chem, vol.67, 2005. ,
, Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells, Oncogene, vol.20, issue.37, pp.5225-5256, 2001.
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis, J Biol Chem, vol.277, issue.25, pp.22320-22329, 2002. ,
Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity, Mol Cell Biol, vol.24, issue.19, pp.8541-55, 2004. ,
,
, Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSODmediated ROS elimination, Mol Cell, vol.9, issue.5, pp.1017-1046, 2002.
NF-kappaB signals induce the expression of c-FLIP, Mol Cell Biol, vol.21, issue.16, pp.5299-305, 2001. ,
Identification of inhibitors of TRAIL-induced death (ITIDs) ,
, in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach, J Biol Chem, vol.276, issue.41, 2001.
Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIP(short), J Immunol, vol.172, issue.4, pp.2194-200, 2004. ,
Defective death receptor signaling as a cause of tumor immune escape, Semin Cancer Biol, vol.12, issue.1, pp.51-56, 2002. ,
Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis, Cancer Res, vol.61, issue.6, pp.2759-65, 2001. ,
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape, Science, vol.274, issue.5291, pp.1363-1369, 1996. ,
,
, Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF
, Akt signaling in human multiple myeloma cells: therapeutic implications, Oncogene, vol.21, issue.37, pp.5673-83, 2002.
,
, Fas expression and function in human lung tumours with overexpression of FasL in small cell lung carcinoma, J Pathol, vol.201, issue.2, pp.268-77, 2003.
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice, Oncogene, vol.22, issue.12, pp.1822-1857, 2003. ,
Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis, Blood, vol.91, issue.8, pp.2875-85, 1998. ,
, Western blot analysis of E2F1 and c-FLIP expression in 5 representative adenocarcinoma lung tumor (T) and their matched normal lung (N)