First results of molecular imaging (FDG and FES) in prospective study for selecting second line hormonotherapy in estrogen receptors positive metastatic breast cancer patients

B. Maucherat; A. Leduc-Pennec; N. Fleury; Ludovic Ferrer; E. Bourbouloux; H. Simon; M. Le Thiec; D. Rusu; V. Fleury; M. Colombie; A. Morel; Françoise Kraeber-Bodéré; Loïc Campion; Caroline Rousseau

Journal articles

First results of molecular imaging (FDG and FES) in prospective study for selecting second line hormonotherapy in estrogen receptors positive metastatic breast cancer patients

B. Maucherat ¹ A. Leduc-Pennec ² N. Fleury ³ Ludovic Ferrer ^{4, 5} E. Bourbouloux ⁶ H. Simon ⁷ M. Le Thiec ¹ D. Rusu ¹ V. Fleury ¹ M. Colombie ¹ A. Morel ¹ Françoise Kraeber-Bodéré ^{4, 1} Loïc Campion ^{8, 9} Caroline Rousseau ^{4, 1}

1 Service de médecine nucléaire [Saint-Herblain]

2 Service de médecine nucléaire [Brest]

3 Délégation à la recherche clinique [CHU Nantes]

4 CRCINA-ÉQUIPE 13 - Nuclear Oncology

CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers

5 Département de Physique [Saint Herblain]

6 Département d'Oncologie [Saint Herblain]

7 Département de Radio-Oncologie [CHRU Brest]

8 CRCINA-ÉQUIPE 11 - Integrative Oncogenomics of Multiple Myeloma Pathogenesis and Progression

CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers

9 Unité de Biométrie [ICO, Saint Herblain]

Abstract : Aim/Introduction: About 70% of primitive breast cancers had positive estrogen receptors (ER) and may benefit from hormonotherapy. However, ER expression in breast cancer metastases is heterogeneous and about 15% of metastases lost this expression over time. Biopsies were not possible systematically. 16α-18Fluoro-17β-Oestradiol (18FES) is a radiopharmaceutical which predict the response to the first line hormonotherapy. The aim of this prospective study (NCT03442504) was to determine the predictive value of PET at the patient level, before a second line hormonotherapy (2nd- HT) on the FDG response obtained at 6 weeks of treatment. Materials and Methods: We prospectively included 12 ER+ metastatic breast cancer patients, HER2 negative, in progression despite first line hormonotherapy. For the complete study, 60 patients will be included. Due to 2nd-HT proposed by oncologist, we performed 18FES PET-CT (18FES-BL) and 18FDG PET-CT (18FDG-BL) at baseline in the month before the new treatment introduction. Follow-up with 18FDG PET-CT and CT

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Journal articles

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Life Sciences [q-bio] / Cancer

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https://www.hal.inserm.fr/inserm-02337440
Contributor : Elizabeth Bernardo <>
Submitted on : Tuesday, October 29, 2019 - 2:28:28 PM
Last modification on : Sunday, October 25, 2020 - 7:06:29 AM
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First results of molecular imaging (FDG and FES) in prospective study for selecting second line hormonotherapy in estrogen receptors positive metastatic breast cancer patients

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First results of molecular imaging (FDG and FES) in prospective study for selecting second line hormonotherapy in estrogen receptors positive metastatic breast cancer patients

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