Y. N. Wang and M. C. Hung, Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family, Cell Biosci, vol.2, p.13, 2012.

T. M. Brand, M. Iida, N. Luthar, M. M. Starr, E. J. Huppert et al., Nuclear EGFR as a molecular target in cancer, Radiother. Oncol, vol.108, pp.370-377, 2013.

H. W. Lo, Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications, Discov. Med, vol.10, pp.44-51, 2010.

G. Carpenter and H. J. Liao, Receptor tyrosine kinases in the nucleus, Cold Spring Harb. Perspect. Biol, vol.5, p.8979, 2013.

C. R. Chong and P. A. Janne, The quest to overcome resistance to EGFR-targeted therapies in cancer, Nat. Med, vol.19, pp.1389-1400, 2013.

F. Morgillo, W. Y. Kim, E. S. Kim, F. Ciardiello, W. K. Hong et al., Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib, Clin Cancer Res, vol.13, pp.2795-2803, 2007.

A. Hurbin, M. Wislez, B. Busser, M. Antoine, C. Tenaud et al., Insulin-like growth factor-1 receptor inhibition overcomes gefitinib resistance in mucinous lung adenocarcinoma, J. Pathol, vol.225, pp.83-95, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00598462

B. Busser, L. Sancey, V. Josserand, C. Niang, M. C. Favrot et al., Amphiregulin promotes BAX inhibition and resistance to gefitinib in nonsmall-cell lung cancers, Mol. Ther, vol.18, pp.528-535, 2010.

H. Werner and D. Leroith, The role of the insulin-like growth factor system in human cancer, Adv. Canc. Res, vol.68, pp.183-223, 1996.

Y. Lin, H. Liu, A. Waraky, F. Haglund, P. Agarwal et al., SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation, J. Cell. Physiol, vol.232, pp.2722-2730, 2017.

D. Warsito, S. Sjostrom, S. Andersson, O. Larsson, and B. Sehat, Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF, EMBO Rep, vol.13, pp.244-250, 2012.

T. Aleksic, M. M. Chitnis, O. V. Perestenko, S. Gao, P. H. Thomas et al., Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells, Cancer Res, vol.70, pp.6412-6419, 2010.

H. Deng, Y. Lin, M. Badin, D. Vasilcanu, T. Stromberg et al., Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9, Biochem. Biophys. Res. Commun, vol.404, pp.667-671, 2011.

S. Packham, D. Warsito, Y. Lin, S. Sadi, R. Karlsson et al., Nuclear translocation of IGF-1R via p150(Glued) and an importin-beta/RanBP2-dependent pathway in cancer cells, Oncogene, vol.34, pp.2227-2238, 2015.

B. Sehat, A. Tofigh, Y. Lin, E. Trocme, U. Liljedahl et al., SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor, Sci. Signal, vol.3, p.10, 2010.

J. C. Van-gaal, M. H. Roeffen, U. E. Flucke, J. A. Van-der-laak, G. Van-der-heijden et al., Simultaneous targeting of insulin-like growth factor-1 receptor and anaplastic lymphoma kinase in embryonal and alveolar rhabdomyosarcoma: a rational choice, Eur. J. Cancer, vol.49, pp.3462-3470, 2013.

I. Asmane, E. Watkin, L. Alberti, A. Duc, P. Marec-berard et al., Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas, Eur. J. Cancer, vol.48, pp.3027-3035, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00852035

A. S. Bodzin, Z. Wei, R. Hurtt, T. Gu, and C. Doria, Gefitinib resistance in HCC mahlavu cells: upregulation of CD133 expression, activation of IGF-1R signaling pathway, and enhancement of IGF-1R nuclear translocation, J. Cell. Physiol, vol.227, pp.2947-2952, 2012.

M. B. Beasley, E. Brambilla, and W. D. Travis, The 2004 World Health Organization classification of lung tumors, Semin. Roentgenol, vol.40, pp.90-97, 2005.

W. D. Travis, E. Brambilla, M. Noguchi, A. G. Nicholson, K. Geisinger et al., International association for the study of lung cancer/american thoracic society/European respiratory society: international multidisciplinary classification of lung adenocarcinoma: executive summary, Proc. Am. Thorac. Soc, vol.8, pp.381-385, 2011.

D. Dayde, M. Guerard, P. Perron, A. S. Hatat, C. Barrial et al., Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival, Oncogene, vol.35, pp.3986-3994, 2016.

S. Y. Lin, K. Makino, W. Xia, A. Matin, Y. Wen et al., Nuclear localization of EGF receptor and its potential new role as a transcription factor, Nat. Cell Biol, vol.3, pp.802-808, 2001.

M. Isokane, M. Hieda, S. Hirakawa, M. Shudou, K. Nakashiro et al., Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription, J. Cell Sci, vol.121, pp.3608-3618, 2008.

C. Berasain and M. A. Avila, Amphiregulin, Semin. Cell Dev. Biol, vol.28, pp.31-41, 2014.

B. Busser, L. Sancey, E. Brambilla, J. L. Coll, and A. Hurbin, The multiple roles of amphiregulin in human cancer, Biochim. Biophys. Acta, vol.1816, pp.119-131, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00602082

G. R. Johnson, T. Saeki, N. Auersperg, A. W. Gordon, M. Shoyab et al., Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: nuclear localization of endogenous amphiregulin, Biochem. Biophys. Res. Commun, vol.180, pp.481-488, 1991.

B. Modrell, V. L. Mcdonald, and M. Shoyab, The interaction of amphiregulin with nuclei and putative nuclear localization sequence binding proteins, Growth Factors, vol.7, pp.305-314, 1992.

M. Dang, N. Armbruster, M. A. Miller, E. Cermeno, M. Hartmann et al., Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways, Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.9776-9781, 2013.

S. Fukuda, H. Nishida-fukuda, H. Nakayama, H. Inoue, and S. Higashiyama, Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding, Biochem. Biophys. Res. Commun, vol.420, pp.315-320, 2012.

M. I. Aslam, S. Hettmer, J. Abraham, D. Latocha, A. Soundararajan et al., Dynamic and nuclear expression of PDGFRalpha and IGF-1R in alveolar Rhabdomyosarcoma, Mol. Cancer Res, vol.11, pp.1303-1313, 2013.

H. W. Lo, W. Xia, Y. Wei, M. Ali-seyed, S. F. Huang et al., Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer, Cancer Res, vol.65, pp.338-348, 2005.

R. Dziadziuszko, D. T. Merrick, S. E. Witta, A. D. Mendoza, B. Szostakiewicz et al., Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression, J. Clin. Oncol, vol.28, pp.2174-2180, 2010.

V. Jeannot, B. Busser, E. Brambilla, M. Wislez, B. Robin et al., The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism, Int. J. Cancer, vol.134, pp.2560-2571, 2014.

W. C. Huang, Y. J. Chen, L. Y. Li, Y. L. Wei, S. C. Hsu et al., Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells, J. Biol. Chem, vol.286, pp.20558-20568, 2011.

C. Li, M. Iida, E. F. Dunn, A. J. Ghia, and D. L. Wheeler, Nuclear EGFR contributes to acquired resistance to cetuximab, Oncogene, vol.28, pp.3801-3813, 2009.