M. J. Robinson and M. H. Cobb, Mitogen-activated protein kinase pathways, Curr Opin Cell Biol, vol.9, pp.180-186, 1997.

S. Y. Fuchs, V. Adler, M. R. Pincus, and Z. Ronai, MEKK1/JNK signaling stabilizes and activates p53, Proc Natl Acad Sci, vol.95, pp.10541-10547, 1998.

C. Huang, W. Y. Ma, A. Maxiner, Y. Sun, and Z. Dong, p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389, J Biol Chem, vol.274, pp.12229-12264, 1999.

D. Keller, X. Zeng, X. Li, M. Kapoor, M. S. Iordanov et al., The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53, Biochem Biophys Res Commun, vol.261, pp.464-71, 1999.

D. V. Bulavin, Y. Higashimoto, I. J. Popoff, W. A. Gaarde, V. Basrur et al., Initiation of a G 2 /M checkpoint after ultraviolet radiation requires p38 kinase, Nature, vol.411, pp.102-109, 2001.

D. W. Abbott and J. T. Holt, Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G 2 /M checkpoint arrest in cells exposed to ionizing radiation, J Biol Chem, vol.274, pp.2732-2774, 1999.

D. Tang, D. Wu, A. Hirao, J. M. Lahti, L. Liu et al., ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53, J Biol Chem, vol.277, pp.12710-12717, 2002.

P. Dent, A. Yacoub, P. B. Fisher, M. P. Hagan, and S. Grant, MAPK pathways in radiation responses, Oncogene, vol.22, pp.5885-96, 2003.

J. D. Weber, J. R. Jeffers, J. E. Rehg, D. H. Randle, G. Lozano et al., p53-independent functions of the p19(ARF) tumor suppressor, Genes Dev, vol.14, pp.2358-65, 2000.

W. G. Yarbrough, M. Bessho, A. Zanation, J. E. Bisi, and Y. Xiong, Human tumor suppressor ARF impedes S-phase progression independent of p53, Cancer Res, vol.62, pp.1171-1178, 2002.

P. G. Hemmati, B. Gillissen, C. Von-haefen, J. Wendt, L. Starck et al., Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis, Oncogene, vol.21, pp.3149-61, 2002.

M. Sugimoto, M. L. Kuo, M. F. Roussel, and C. J. Sherr, Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing, Mol Cell, vol.11, pp.415-439, 2003.

S. Rocha, K. J. Campbell, and N. D. Perkins, p53-and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor, Mol Cell, vol.12, pp.15-25, 2003.

B. Eymin, C. Leduc, J. L. Coll, E. Brambilla, and S. Gazzeri, p14ARF induces G 2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice, Oncogene, vol.22, pp.1822-1857, 2003.

C. G. Takizawa and D. O. Morgan, Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C, Curr Opin Cell Biol, vol.12, pp.658-65, 2000.

D. V. Bulavin, Y. Higashimoto, Z. N. Demidenko, S. Meek, P. Graves et al., Dual phosphorylation controls Cdc25 phosphatases and mitotic entry, Nat Cell Biol, vol.5, pp.545-51, 2003.

D. V. Bulavin, Z. N. Demidenko, C. Phillips, S. A. Moody, F. Jr et al., Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in premidblastula embryos, Cell Cycle, vol.2, pp.263-269, 2003.

J. R. Hutchins and P. R. Clarke, Many fingers on the mitotic trigger: Post-translational regulation of the Cdc25C phosphatase, Cell Cycle, vol.3, pp.41-46, 2004.

C. Y. Peng, P. R. Graves, R. S. Thoma, Z. Wu, and A. S. Shaw, Piwnica-Worms H. Mitotic and G 2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216, Science, vol.277, pp.1501-1506, 1997.

B. Furnari, N. Rhind, and P. Russell, Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase, Science, vol.277, pp.1495-1502, 1997.

B. Eymin, L. Karayan, P. Seite, C. Brambilla, E. Brambilla et al., Human ARF binds E2F1 and inhibits its transcriptional activity, Oncogene, vol.10, pp.1033-1041, 2001.

S. V. Singh, A. Herman-antosiewicz, A. V. Singh, K. L. Lew, S. K. Srivastava et al., Sulforaphane-induced G 2 /M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C, J Biol Chem, vol.279, pp.25813-25835, 2004.

Y. Qi, M. A. Gregory, Z. Li, J. P. Brousal, K. West et al., p19ARF directly and differentially controls the functions of c-Myc independently of p53, Nature, vol.431, pp.712-719, 2004.

D. Bertwistle, M. Sugimoto, and C. J. Sherr, Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23, Mol Cell Biol, vol.24, pp.985-96, 2004.

C. J. Sherr, Tumor surveillance via the ARF-p53 pathway, Genes Dev, vol.12, pp.2984-91, 1998.

M. Serrano, A. W. Lin, M. E. Mccurrach, D. Beach, and S. W. Lowe, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, vol.88, pp.593-602, 1997.

I. Palmero, C. Pantoja, and M. Serrano, p19ARF links the tumour suppressor p53 to Ras, Nature, vol.395, pp.125-131, 1998.

R. Sreeramaneni, A. Chaudhry, M. Mcmahon, C. J. Sherr, and K. Inoue, Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor, Mol Cell Biol, vol.25, pp.220-252, 2005.

M. Cheng, V. Sexl, C. J. Sherr, and M. F. Roussel, Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1), Proc Natl Acad Sci, vol.95, pp.1091-1097, 1998.

J. H. Wright, E. Munar, D. R. Jameson, P. R. Andreassen, R. L. Margolis et al., Mitogen-activated protein kinase kinase activity is required for the G 2 /M transition of the cell cycle in mammalian fibroblasts, Proc Natl Acad Sci, vol.96, pp.11335-11375, 1999.

C. Hayne, G. Tzivion, and Z. Luo, Raf-1/MEK/MAPK pathway is necessary for the G 2 /M transition induced by nocodazole, J Biol Chem, vol.275, pp.31876-82, 2000.

E. C. Roberts, P. S. Shapiro, T. S. Nahreini, G. Pages, J. Pouyssegur et al., Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis, Mol Cell Biol, vol.22, pp.7226-7267, 2002.

A. Harding, N. Giles, A. Burgess, J. F. Hancock, and B. G. Gabrielli, Mechanism of mitosis-specific activation of MEK1, J Biol Chem, vol.278, pp.16747-54, 2003.

Y. Yan, R. S. Spieker, M. Kim, S. M. Stoeger, and K. H. Cowan, BRCA1-mediated G 2 /M cell cycle arrest requires ERK1/2 kinase activation, Oncogene, 2005.

M. Donzelli and G. F. Draetta, Regulating mammalian checkpoints through Cdc25 inactivation, EMBO Rep, vol.4, pp.671-678, 2003.

Y. Sanchez, C. Wong, R. S. Thoma, R. Richman, Z. Wu et al., Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25, Science, vol.277, pp.1497-501, 1997.

I. A. Manke, A. Nguyen, D. Lim, M. Q. Stewart, A. E. Elia et al., MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G 2 /M transition and S phase progression in response to UV irradiation, Mol Cell, vol.17, pp.37-48, 2005.

M. Athar, A. L. Kim, N. Ahmad, H. Mukhtar, J. Gautier et al., Mechanism of ultraviolet B-induced cell cycle arrest in G 2 /M phase in immortalized skin keratinocytes with defective p53, Biochem Biophys Res Commun, vol.277, pp.107-118, 2000.

X. Wang, C. H. Mcgowan, M. Zhao, L. He, J. S. Downey et al., Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest, Mol Cell Biol, vol.20, pp.4543-52, 2000.

K. Raj, P. Ogston, and P. Beard, Virus-mediated killing of cells that lack p53 activity, Nature, vol.412, pp.914-921, 2001.

H. Zhao and J. L. Watkins, Piwnica-Worms H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints, Proc Natl Acad Sci, vol.99, pp.14795-800, 2002.

L. Busino, M. Chiesa, G. F. Draetta, and M. Donzelli, Cdc25A phosphatase: Combinatorial phosphorylation, ubiquitylation and proteolysis, Oncogene, vol.23, pp.2050-2056, 2004.