Low glucose microenvironment of normal kidney cells stabilizes a subset of messengers involved in angiogenesis - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Physiological Reports Année : 2015

Low glucose microenvironment of normal kidney cells stabilizes a subset of messengers involved in angiogenesis

Résumé

As glucose is a mandatory nutrient for cell proliferation and renewal, it is suspected that glucose microenvironment is sensed by all cell types to regulate angiogenesis. Several glucose-sensing components have been partially described to respond to high glucose levels. However, little is known about the response to low glucose. Here, we used well-differentiated isolated normal rat renal tubules under normal oxygenation conditions to assess the angio-genic response to low glucose. In apparent paradox, but confirming observations made separately in other models, high glucose but also low glucose increased mRNA level of vascular endothelial growth factor A (VEGFA). A subset of mRNAs including hypoxia-inducible factor 1A (HIF1A), angiopoie-tin receptor (TIE-2), and VEGF receptor 2 (FLK1) were similarly glucose-sensitive and responded to low glucose by increased stability independently of HIF1A and HIF2A proteins. These results contribute to gain some insights as to how normal cells response to low glucose may play a role in the tumor microenvironment.
Fichier principal
Vignette du fichier
De Laplanche et al., Physiological Reports, 2014.pdf (1.11 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-02337370 , version 1 (29-10-2019)

Identifiants

Citer

Elodie de Laplanche, Asma Boudria, Estelle Dacheux, Anne Vincent, Nicolas Gadot, et al.. Low glucose microenvironment of normal kidney cells stabilizes a subset of messengers involved in angiogenesis. Physiological Reports, 2015, 3 (1), pp.e12253. ⟨10.14814/phy2.12253⟩. ⟨inserm-02337370⟩
43 Consultations
70 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More