Antigène HBs positif en l'absence de toute infection par le virus de l'hépatite B : la face 1 cachée de l'Ag HBs

Abstract : French recommendations for the screening of hepatitis B virus (HBV) infection were updated in 2019 with the association of three markers: HBs Ag, anti-HBs Ab and anti-HBc Ab. These three markers allow identification of infected patients, vaccinated patients and patients who have been in contact with HBV. A positive HBs Ag is usually associated with HBV infection but this interpretation must take into account the clinical context. In particular, the absence of anti-HBc Ab, normal ALAT levels and the absence of jaundice can be associated with recent HBV vaccination or false-positive HBs Ag. Recent HBV vaccination can usually be confirmed by patient questioning, while confirmatory tests are useful to detect false positive HBs Ag. If necessary, a second sample can be requested to confirm the interpretation.
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Submitted on : Tuesday, October 29, 2019 - 2:50:13 PM
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José Bras Cachinho, Maud François, Karl Stefic, Julien Marlet. Antigène HBs positif en l'absence de toute infection par le virus de l'hépatite B : la face 1 cachée de l'Ag HBs. Annales de Biologie Clinique, John Libbey Eurotext, 2019, 77 (5), pp.543-548. ⟨10.1684/abc.2019.1483⟩. ⟨inserm-02336405⟩

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