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Journal articles
Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
Abstract : Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n = 125). The frequency of CD107 + NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p = 0 002) and correlated with the plasma levels of estradiol (correlation coefficient r = 0 634; p < 0 0001). Our results clearly show sex differences in degranulation activity of intrahepatic NK cells of HBV-infected patients. This probably contributes to the ability of females to better deal with HBV disease.
Cited literature [23 references]
https://www.hal.inserm.fr/inserm-02333383
Contributor : Patrice Marche <>
Submitted on : Friday, October 25, 2019 - 12:18:49 PM
Last modification on : Friday, November 20, 2020 - 1:00:06 PM
Long-term archiving on: : Sunday, January 26, 2020 - 3:04:25 PM
Contributor : Patrice Marche <>
Submitted on : Friday, October 25, 2019 - 12:18:49 PM
Last modification on : Friday, November 20, 2020 - 1:00:06 PM
Long-term archiving on: : Sunday, January 26, 2020 - 3:04:25 PM
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Macek Jilkova_MedInf-2017.pdf
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