Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels

Zuzana Macek Jilkova 1 Thomas Decaens 1, 2 Alice Marlu 2 Hélène Marche 1 Evelyne Jouvin-Marche 1 Patrice Marche 1
1 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
2 Département de Gastroentérologie et hépatologie
Abstract : Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n = 125). The frequency of CD107 + NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p = 0 002) and correlated with the plasma levels of estradiol (correlation coefficient r = 0 634; p < 0 0001). Our results clearly show sex differences in degranulation activity of intrahepatic NK cells of HBV-infected patients. This probably contributes to the ability of females to better deal with HBV disease.
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Zuzana Macek Jilkova, Thomas Decaens, Alice Marlu, Hélène Marche, Evelyne Jouvin-Marche, et al.. Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels. Mediators of Inflammation, Hindawi Publishing Corporation, 2017, 2017, pp.1-5. ⟨10.1155/2017/3214917⟩. ⟨inserm-02333383⟩

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