Cancer statistics, CA Cancer J Clin, vol.63, issue.1, pp.61347-61347, 2012. ,
Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials, World J Gastroenterol, vol.20, issue.5, pp.1268-1288, 2014. ,
Global trends and predictions in hepatocellular carcinoma mortality ,
, J Hepatol, vol.67, issue.2, pp.302-309, 2017.
Biomarkers for the early diagnosis of hepatocellular carcinoma, World J Gastroenterol, vol.21, issue.37, p.10573, 2015. ,
,
Circulating osteopontin and prediction of hepatocellular carcinoma development in a large European population, Cancer Prev Res (Phila), vol.9, issue.9, pp.758-765, 2016. ,
Hepatocellular carcinoma: clinical frontiers and perspectives, Gut, vol.63, issue.5, pp.844-855, 2014. ,
, , 2014.
Global cancer statistics, CA Cancer J Clin, vol.65, issue.2, pp.87-108, 2012. ,
Review of hepatocellular carcinoma: epidemiology, etiology, and carcinogenesis ,
, Ozakyol A. Global epidemiology of hepatocellular carcinoma (HCC epidemiology), J Gastrointest Cancer, vol.16, issue.1, p.1, 2017.
, , vol.48, pp.238-240
Hepatocellular carcinoma as a social and medical problem in the Russian Federation, Medicinskij sovet, vol.10, pp.139-148, 2016. ,
, Niger J Clin Pract, vol.20, issue.10, pp.1267-1272, 2017.
Screening and early diagnosis of hepatocellular carcinoma ,
, Aktual'naa infektologia, vol.6, issue.2, pp.70-76, 2018.
Liver hepatocellular carcinoma (review), Oncol Rep, vol.37, issue.3, pp.1291-1300, 2017. ,
Performance of serum glypican 3 in diagnosis of hepatocellular carcinoma: a meta-analysis, Ann Hepatol, vol.18, issue.1, pp.58-67, 2018. ,
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma, J Hepatol, 2005. ,
GP73, a resident Golgi glycoprotein, is sensibility and specificity for hepatocellular carcinoma of diagnosis in a hepatitis B-endemic Asian population, Med Oncol, vol.43, issue.6, pp.339-345, 2010. ,
Clinical significance and expression of serum Golgi protein 73 in primary hepatocellular carcinoma, J Cancer Res Ther, vol.14, issue.6, pp.1239-1244, 2018. ,
SCCA antigen combined with alpha-fetoprotein as serologic markers of HCC, Int J Cancer, vol.117, issue.3, pp.506-509, 2005. ,
Clinical validation of combined serological biomarkers for improved hepatocellular carcinoma diagnosis in 961 patients, Clin Chim Acta, vol.383, issue.1-2, pp.59-64, 2007. ,
,
Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC), J Gastroenterol Hepatol, vol.29, issue.8, pp.1637-1644, 2014. ,
Squamouse cell carcinoma antigenimmunoglobulin M complexes as novel biomarkers for hepatocellular carcinoma, Liver Int, vol.38, issue.10, pp.2558-2565, 2005. ,
Elevated plasma osteopontin levels in patients with hepatocellular carcinoma, Am J Gastroenterol, vol.101, issue.9, pp.2051-2059, 2006. ,
Identification of osteopontin as a novel marker for early hepatocellular carcinoma, Hepatology, vol.55, issue.2, pp.483-490, 2012. ,
Comparison osteopontin vs AFP for the diagnosis of HCC: a meta-analysis, Clin Res Hepatol Gastroenterol, vol.38, issue.6, pp.706-714, 2014. ,
Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma, Med Oncol, vol.32, issue.3, p.59, 2015. ,
Evaluation of annexin II as a potential serum marker for hepatocellular carcinoma using a developed sandwich ELISA method, Int J Mol Med, vol.24, issue.6, pp.765-771, 2009. ,
,
Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma, Carcinogenesis, vol.34, issue.3, pp.595-604, 2013. ,
Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients, World J Hepatol, vol.9, issue.9, pp.469-476, 2017. ,
,
Clinical utility of highly sensitive lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein <20 ng/ml, Cancer Sci, vol.102, issue.5, pp.1025-1031, 2011. ,
Highly sensitive lens culinaris agglutininreactive ?-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease, Oncol Rep, vol.26, issue.5, pp.1227-1233, 2011. ,
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study, Future Oncol, vol.8, issue.12, pp.70233-70237, 2012. ,
Sensitivity and specificity of dickkopf-1 protein in serum for diagnosing hepatocellular carcinoma: a meta-analysis, Int J Biol Markers, vol.29, issue.4, pp.403-410, 2014. ,
Circulating predictive and diagnostic biomarkers for hepatitis B virusassociated hepatocellular carcinoma, World J Gastroenterol, vol.22, issue.37, pp.8271-8282, 2016. ,
Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma, Asian Pac J Trop Med, vol.10, issue.4, pp.409-413, 2017. ,
, Int J Cancer, vol.137, issue.2, pp.385-394, 2015.
Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis, Oncotarget, vol.8, issue.28, pp.46234-46248, 2017. ,
Evaluation of midkine as a diagnostic serum biomarker in hepatocellular carcinoma, Clin Cancer Res, vol.19, issue.14, pp.3944-3954, 2013. ,
Midkine increases diagnostic yield in AFP negative and NASH-related hepatocellular carcinoma, Int J Hepatol, vol.11, issue.5, p.155800, 2015. ,
Plasma minichromosome maintenance complex component 6 is a novel biomarker for hepatocellular carcinoma patients, Hepatol Res, vol.44, issue.13, pp.1347-1356, 2014. ,
Serum thioredoxin is a diagnostic marker for hepatocellular carcinoma, Oncotarget, vol.6, issue.11, pp.9551-9563, 2015. ,
Serum soluble urokinase plasminogen activator receptor as a screening test for the early diagnosis of hepatocellular carcinoma, Liver Int, vol.35, issue.2, pp.601-607, 2015. ,
Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C. A systematic review and critical analysis, Ann Intern Med, vol.139, issue.1, pp.46-50, 2003. ,
Improved performance of serum alpha-fetoprotein for hepatocellular carcinoma diagnosis in HCV cirrhosis with normal alanine transaminase, Cancer Epidemiol Biomarkers Prev, vol.26, issue.7, pp.1085-1092, 2017. ,
Alpha-foetoprotein (AFP): a multi-purpose marker in hepatocellular carcinoma ,
, Clin Chim Acta, vol.463, pp.39-44, 2016.
Did AFP-L3 save ultrasonography in community screening?, Kaohsiung J Med Sci, vol.34, issue.10, pp.583-587, 2018. ,
Screening for hepatocellular carcinoma in Alaska natives infected with chronic hepatitis B: a 16-year population-based study, Hepatology, vol.32, issue.4, pp.842-846, 2000. ,
,
Utility of lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma, Clin Gastroenterol Hepatol, vol.7, issue.1, pp.355-362, 2009. ,
Validation of a novel model for the early detection of hepatocellular carcinoma, Clin Proteomics, vol.16, issue.2, 2019. ,
Diagnostic accuracy of alpha-fetoprotein and des-gamma-carboxy prothrombin in screening for hepatocellular carcinoma in liver transplant candidates, Z Gastroenterol, vol.41, issue.12, pp.1296-1305, 2011. ,
Diagnostic value of serum PIVKA-II levels for BCLC early hepatocellular carcinoma and correlation with HBV DNA, Cancer Biomark, vol.23, issue.2, pp.235-242, 2018. ,
Effectiveness of PIVKA-II in the detection of hepatocellular carcinoma based on real-world clinical data, BMC Cancer, vol.17, issue.1, p.608, 2017. ,
Alpha-L-fucosidase serves as a prognostic indicator for intrahepatic cholangiocarcinoma and inhibits its invasion capacity, Biomed Res Int, p.8182575, 2018. ,
Value of the serum measurement of alpha-L-fucosidase in the diagnosis of hepatocarcinoma, Med Clin (Barc), vol.93, issue.7, pp.241-243, 1989. ,
Prediction of the development of hepato-cellular-carcinoma in patients with liver cirrhosis by the serial determinations of serum alpha-L-fucosidase activity, Intern Med, vol.38, issue.12, pp.927-931, 1999. ,
Prediction of invasive activities in hepatocellular carcinomas with special reference to alpha-fetoprotein and des-gammacarboxyprothrombin, Jpn J Clin Oncol, vol.33, issue.10, pp.522-526, 2003. ,
GPC-HCC model: a combination of glybican-3 with other routine parameters improves the diagnostic efficacy in hepatocellular carcinoma, Tumor Biol, vol.37, issue.9, pp.12571-12577, 2016. ,
,
Diagnostic accuracy of glypican-3 in differentiating hepatocellular carcinoma from metastatic liver tumours, J Pak Med Assoc, vol.68, issue.7, pp.1029-1031, 2018. ,
Research progress on GP73 in malignant tumors, Onco Targets Ther, vol.11, pp.7417-7421, 2018. ,
,
Evaluation of prothrombin induced by vitamin K absence, macrophage migration inhibitory factor and Golgi protein-73 versus alpha fetoprotein for hepatocellular carcinoma diagnosis and surveillance, Scand J Clin Lab Invest, vol.77, issue.3, pp.175-183, 2017. ,
Studying the impact of Golgi protein 73 serving as a candidate biomarker in early diagnosis for hepatocellular carcinoma among Saudi patients, Asian Pac J Cancer Prev, vol.20, issue.1, pp.12069-12074, 2014. ,
,
Circulating SCCA-IgM complex is a useful biomarker to predict the outcome of therapy in hepatocellular carcinoma patients, Scand J Clin Lab Invest, vol.77, issue.6, pp.448-453, 2017. ,
Squamous cell carcinoma antigen in human liver carcinogenesis, J Clin Pathol, vol.61, issue.4, pp.445-447, 2008. ,
MicroRNAs: emerging novel clinical biomarkers for hepatocellular carcinomas, J Clin Med, vol.4, issue.8, pp.1631-1650, 2015. ,
Osteopontin in hepatocellular carcinoma: a possible biomarker for diagnosis and follow-up, Cytokine, vol.99, pp.59-65, 2017. ,
Human osteopontin: potential clinical applications in cancer (review), Int J Mol Med, vol.39, issue.6, pp.1327-1337, 2017. ,
The role of osteopontin in the progression of solid organ tumour, Cell Death Dis, vol.9, issue.3, p.356, 2018. ,
Osteopontin: a non-invasive parameter of portal hypertension and prognostic marker of cirrhosis, World J Gastroenterol, vol.22, issue.12, pp.3441-3450, 2016. ,
Possible role of microRNA-122 in modulating multidrug resistance of hepatocellular carcinoma, Indian J Clin Biochem, vol.15, issue.9, pp.21-30, 2015. ,
The role of annexin A2 in tumorigenesis and cancer progression, Cancer Microenviron, vol.4, issue.2, pp.199-208, 2011. ,
Extracellular annexin II is associated with divalent cationdependent tumor cell-endothelial cell adhesion of metastatic RAW117 large-cell lymphoma cells, J Cell Biochem, 1993. ,
Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro, Gut, vol.53, issue.3, pp.993-1000, 2004. ,
Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression, Exp Mol Pathol, vol.81, issue.2, pp.146-156, 2006. ,
Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer, J Cell Biochem, vol.105, issue.2, pp.370-380, 2008. ,
Screening for hepatocellular carcinoma and cholangiocarcinoma: can biomarkers replace imaging?, Curr Hepatol Rep, vol.14, issue.2, pp.128-138, 2015. ,
,
Recent progress of Wnt pathway inhibitor dickkopf-1 in liver cancer, J Nanosci Nanotechnol, vol.18, issue.8, pp.5192-5206, 2018. ,
Developing slow-off dickkopf-1 aptamers for early-diagnosis of REVIEWS hepatocellular carcinoma, Talanta, vol.194, pp.422-429, 2019. ,
The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma, Br J Cancer, vol.108, issue.3, pp.621-628, 2013. ,
Axl as a mediator of cellular growth and survival, Oncotarget, vol.5, pp.8818-8852, 2014. ,
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance, Clin Cancer Res, vol.19, issue.1, pp.279-290, 2013. ,
Axl receptor tyrosine kinase expression in breast cancer, J Clin Pathol, vol.67, issue.8, pp.690-696, 2014. ,
,
Van Schaeybroeck S. AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer, Clin Cancer Res, vol.20, issue.1, pp.164-175, 2014. ,
Diagnostic and prognostic value of talin-1 and midkine as tumor markers in hepatocellular carcinoma in Egyptian patients, Asian Pac J Cancer Prev, vol.134, issue.5, pp.1503-1508, 2014. ,
Essential role of MCM proteins in premeiotic DNA replication ,
, Mol Biol Cell, vol.13, issue.2, pp.435-444, 2002.
MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence, J Exp Clin Cancer Res, vol.37, issue.1, p.10, 2018. ,
MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression, BMC Cancer, vol.18, issue.1, 0200. ,
Enzymatic synthesis of deoxyribonucleotides. IV. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia Coli B, 147. Mollbrink A., Jawad R, vol.239, pp.3436-3444, 1964. ,
Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome, Int J Immunopathol Pharmacol, vol.27, issue.2, pp.169-183, 2014. ,
,
Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma, Oncotarget, vol.9, issue.96, pp.36849-36866, 2018. ,
Clinical significance of the thioredoxin system and thioredoxin-domain-containing protein family in hepatocellular carcinoma, Dig Dis Sci, vol.64, issue.1, pp.2090-2098, 2014. ,
The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers, Cancer Epidemiol Biomarkers Prev, vol.23, issue.1, pp.144-153, 2014. ,
,
Role of the GALAD and BALAD-2 serologic models in diagnosis of hepatocellular carcinoma and prediction of survival in patients, Clin Gastroenterol Hepatol, vol.14, issue.6, pp.875-886, 2016. ,
Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma, Expert Rev Mol Diagn, vol.18, issue.8, pp.713-722, 2018. ,