Non-IgE mediated mast cell activation
Résumé
Mast cells (MCs) are innate immune cells that are scattered in tissues throughout the organism being particularly abundant at sites exposed to the environment such as the skin and mucosal surfaces. Generally known for their role in IgE-mediated allergies, they have also important functions in the maintenance of tissue integrity by constantly sensing their microenvironment for signals by inflammatory triggers that can comprise infectious agents, toxins, hormones, alarmins, metabolic states, etc. When triggered their main function is to release a whole set of inflammatory mediators, cytokines, chemokines, and lipid products. This allows them to organize the ensuing innate immune and inflammatory response in tight coordination with resident tissue cells, other rapidly recruited immune effector cells as well as the endocrine and exocrine systems of the body. To complete these tasks, MCs are endowed with a large repertoire of receptors allowing them to respond to multiple stimuli or directly interact with other cells. Here we review some of the receptors expressed on MCs (ie, receptors for Immunoglobulins, pattern recognition receptors, nuclear receptors, receptors for alarmins, and a variety of other receptors) and discuss their functional implication in the immune and inflammatory response focusing on non-IgE-mediated activation mechanisms.
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Mots clés
GPCR
IL-1
IL-33
MAS-related GPCR
PPAR
Toll-like receptor
alarmins
aryl hydrocarbon receptor
complement
endothelin receptors
free light chain
glucocorticoid receptor
integrins
mast cell
neuropeptides
neurotensin
nucleotide oligomerization domain-like receptors
pattern recognition receptor
retinoic acid-inducible gene-I-like receptors
sphingosine-1 phosphate
substance P
vitamin D receptor
ATP
CD151
CD37
CD48
CD53
CD63
CD81
CD9
Fc receptor
Domaines
Immunologie
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