The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

Danny Ben-Avraham; Diddahally Govindaraju; Temuri Budagov; Delphine Fradin; Peter Durda; Bing Liu; Sandy Ott; Danielle Gutman; Lital Sharvit; Robert Kaplan; Pierre Bougnères; Alex Reiner; Alan Shuldiner; Pinchas Cohen; Nir Barzilai; Gil Atzmon

doi:10.1126/sciadv.1602025

Journal articles

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

Danny Ben-Avraham ^{1, 2, 3} Diddahally Govindaraju ^{3, 4} Temuri Budagov ^{1, 3} Delphine Fradin ^{5, 6} Peter Durda ⁷ Bing Liu ⁸ Sandy Ott ⁹ Danielle Gutman ¹⁰ Lital Sharvit ¹⁰ Robert Kaplan ¹¹ Pierre Bougnères ^{6, 12, 5} Alex Reiner ^{13, 14} Alan Shuldiner ^{9, 15} Pinchas Cohen ⁸ Nir Barzilai ^{1, 2, 3} Gil Atzmon ^{1, 2, 3, 10, *}

* Corresponding author

1 Department of Medicine [Bronx, NY, USA]

2 Department of Genetics [Bronx, NY, USA]

3 Institute of Aging Research [Bronx, NY, USA]

4 Department of Human Evolutionary Biology

5 U986 - Immunologie et génétique du diabète de type 1, génétique multifactorielle en endocrinologie pédiatrique

6 U 1169 - Thérapie génique, Génomique et Epigénomique

7 Department of Pathology [Colchester, VT, USA]

8 Leonard Davis School of Gerontology [Los Angeles, CA, USA]

9 University of Maryland School of Medicine [Baltimore, MD, USA]

10 Faculty of Natural Sciences - Department of Human Biology [Haifa, Israel]

11 Department of Epidemiology and Population Health [Bronx, NY, USA]

12 Service d'endocrinologie pédiatrique [CHU Bicêtre]

13 School of Public Health - Department of Epidemiology [Seattle, WA, USA]

14 Public Health Sciences Division [Seattle, WA, USA]

15 Geriatrics Research and Education Clinical Center [Baltimore, MD, USA]

Keywords : growth hormone receptor Centenarians IGF-I d3-GHR longevity positive pleiotropy

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Biochemistry, Molecular Biology

Life Sciences [q-bio] / Biochemistry, Molecular Biology / Genomics [q-bio.GN]

Complete list of metadata

Cited literature [66 references] Display Hide Download

https://www.hal.inserm.fr/inserm-02320509
Contributor : Delphine Fradin Connect in order to contact the contributor
Submitted on : Friday, October 18, 2019 - 5:58:54 PM
Last modification on : Saturday, June 25, 2022 - 10:40:02 PM
Long-term archiving on: : Sunday, January 19, 2020 - 4:09:21 PM

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

File

Identifiers

Collections

Citation

Export

Metrics

39

67

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

File

Identifiers

Collections

Citation

Export

Share

Metrics

39

67