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The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

Danny Ben-Avraham 1, 2, 3 Diddahally Govindaraju 3, 4 Temuri Budagov 1, 3 Delphine Fradin 5, 6 Peter Durda 7 Bing Liu 8 Sandy Ott 9 Danielle Gutman 10 Lital Sharvit 10 Robert Kaplan 11 Pierre Bougnères 6, 12, 5 Alex Reiner 13, 14 Alan Shuldiner 9, 15 Pinchas Cohen 8 Nir Barzilai 1, 2, 3 Gil Atzmon 1, 2, 3, 10, *
* Corresponding author
1 Department of Medicine [Bronx, NY, USA]
2 Department of Genetics [Bronx, NY, USA]
3 Institute of Aging Research [Bronx, NY, USA]
4 Department of Human Evolutionary Biology [Cambridge, MA, USA]
5 U986 - Immunologie et génétique du diabète de type 1, génétique multifactorielle en endocrinologie pédiatrique
6 U 1169 - Thérapie génique, Génomique et Epigénomique
7 Department of Pathology [Colchester, VT, USA]
8 Leonard Davis School of Gerontology [Los Angeles, CA, USA]
9 University of Maryland School of Medicine [Baltimore, MD, USA]
10 Faculty of Natural Sciences - Department of Human Biology [Haifa, Israel]
11 Department of Epidemiology and Population Health [Bronx, NY, USA]
12 Service d'endocrinologie pédiatrique [CHU Bicêtre]
13 School of Public Health - Department of Epidemiology [Seattle, WA, USA]
14 Public Health Sciences Division [Seattle, WA, USA]
15 Geriatrics Research and Education Clinical Center [Baltimore, MD, USA]
Keywords : positive pleiotropy longevity d3-GHR IGF-I Centenarians growth hormone receptor
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Danny Ben-Avraham, Diddahally Govindaraju, Temuri Budagov, Delphine Fradin, Peter Durda, et al.. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Science Advances , American Association for the Advancement of Science (AAAS), 2017, 3 (6), pp.e1602025. ⟨10.1126/sciadv.1602025⟩. ⟨inserm-02320509⟩

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