The heterogeneity of osteosarcoma: the role played by cancer stem cells

Abstract : Osteosarcoma is the most common bone sarcoma and is one of the cancer entities characterized by the highest level of heterogeneity in humans. This heterogeneity takes place not only at the macroscopic and microscopic levels, with heterogeneous micro-environmental components, but also at the genomic, transcriptomic and epigenetic levels. Recent investigations have revealed the existence in osteosarcoma of cancer cells with stemness properties. Cancer stem cells are characterized by their specific phenotype and low cycling capacity, and are linked to drug resistance, tumour growth and the metastatic process. In addition, cancer stem cells contribute to the enrichment of tumour heterogeneity. The present manuscript will describe the main characteristic features of cancer stem cells in osteosarcoma and will discuss their impact on maintaining tumour heterogeneity. Their clinical implications will also be briefly addressed.
Complete list of metadatas

Cited literature [83 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02319227
Contributor : Dominique Heymann <>
Submitted on : Thursday, October 17, 2019 - 5:40:34 PM
Last modification on : Tuesday, October 22, 2019 - 1:43:31 AM

File

Schiavone et al Adv Exp Med Bi...
Files produced by the author(s)

Identifiers

Citation

Kristina Schiavone, Delphine Garnier, Marie-Françoise Heymann, Dominique Heymann. The heterogeneity of osteosarcoma: the role played by cancer stem cells. Advances in Experimental Medicine and Biology, Kluwer, 2019, 1139, pp.187-200. ⟨10.1007/978-3-030-14366-4_11⟩. ⟨inserm-02319227⟩

Share

Metrics

Record views

22

Files downloads

5