(. Heydmann, . Inserm-umr_s1110, F. ). Strasbourg, M. B. Phh-isolation.-we-acknowledge-drs, O. Zeisel et al., ) for setting up experimental procedures. Contributors EC, CS, ERV and TFB wrote the manuscript. EC, CS and ML designed experiments. EC and MAO performed experiments, INSERM UMR_S1110

, and benefits from funding from the state managed by the French National Research Agency as part of the Investments for the future programme. EC and ML were supported by a fellowship of the French Ministry for Research and Education (MESR). TFB acknowledges funding by the European Union (ERC-AdG-2014 HEPCIR, EU2020 HEPCAR, EU-Interreg IV-Rhin Supérieur-FEDER-Hepato-Regio-Net) and ARC-IHU (TheraHCC programme) (ARC IHU201301187), CS acknowledges funding by the Agence Nationale de Recherches sur le SIDA (ANRS) (2010-307/2011-415) and the Initiative d'excellence

, Ethics approval Strasbourg University Ethical Committee (Approval # CPP, pp.10-17

, Provenance and peer review Not commissioned; externally peer reviewed

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