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Journal articles
Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection
David Wolski
1, 2
Peter Foote
1
Diana Chen
1
Lia Lewis-Ximenez
3
Catherine Fauvelle
2
Jasneet Aneja
1
Andreas Walker
4
Pierre Tonnerre
1
Almudena Torres-Cornejo
1
Daniel Kvistad
1
Sabrina Imam
5
Michael Waring
6, 7
Damien Tully
6
Todd Allen
6
Raymond Chung
1
Jörg Timm
4
W. Nicholas Haining
5
Arthur Kim
8
Thomas Baumert
2, 9, *
Georg Lauer
1, *
*
Corresponding author
Almudena Torres-Cornejo 1
Author
Daniel Kvistad 1
Author
Sabrina Imam 5
Author
Michael Waring 6, 7
Author
W. Nicholas Haining 5
Author
Arthur Kim 8
Author
Thomas F. Baumert 2, 9
Correspondent author IdHAL : thomas-f-baumert IdRef : https://www.idref.fr/143387898 ResearcherId : http://www.researcherid.com/rid/ABF-4718-2020
Georg Lauer 1
Correspondent author
1
Liver Center - Department of Medicine - Gastrointestinal Division [Boston, MA, USA] (United States)
- HMS - Harvard Medical School [Boston] (25 Shattuck Street Boston, MA 02115 - United States)
- Massachusetts General Hospital [Boston] (55 Fruit Street Boston, MA 02114 - United States)
2
IVH - Institut de Recherche sur les Maladies Virales et Hépatiques (Institut de virologie, 3 rue Koeberlé, 67000 Strasbourg - France)
- UNISTRA - Université de Strasbourg : UMRS1110 (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1110 (101, rue de Tolbiac, 75013 Paris - France)
3
Laboratory of Viral Hepatitis / Laboratório de Hepatites Virais [Rio de Janeiro] (Avenida Brasil 4.365 - Manguinhos, Rio de Janeiro, RJ - Brazil)
- IOC - Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (Avenida Brasil 4.365 - Manguinhos, Rio de Janeiro, RJ - Brazil)
- FIOCRUZ - Fundação Oswaldo Cruz (Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - Brazil)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- FIOCRUZ - Fundação Oswaldo Cruz (Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - Brazil)
4
Institute for Virology [Düsseldorf, Germany] (Germany)
5
Department of Pediatric Oncology [Boston, MA, USA] (Boston, Massachusetts 02115 - United States)
- HMS - Harvard Medical School [Boston] (25 Shattuck Street Boston, MA 02115 - United States)
- Dana-Farber Cancer Institute [Boston] (450 Brookline Ave. Boston, MA 02215 - United States)
6
Ragon Institute of MGH, MIT and Harvard (400 Technology Square, Cambridge, MA 02139 - United States)
7
HHMI - Howard Hughes Medical Institute [Chevy Chase] (4000 Jones Bridge Road, Chevy Chase, MD 20815-6789 - United States)
- HHMI - Howard Hughes Medical Institute (United States)
8
Department of Infectious Disease [Boston] (55 Fruit Street Boston, MA 02114 - United States)
- Massachusetts General Hospital [Boston] (55 Fruit Street Boston, MA 02114 - United States)
9
Pôle hépato-digestif [Strasbourg] (Strasbourg - France)
Abstract : Distinct molecular pathways govern the differentiation of CD8+ effector T cells into memory or exhausted T cells during acute and chronic viral infection, but these are not well studied in humans. Here, we employed an integrative systems immunology approach to identify transcriptional commonalities and differences between virus-specific CD8+ T cells from patients with persistent and spontaneously resolving hepatitis C virus (HCV) infection during the acute phase. We observed dysregulation of metabolic processes during early persistent infection that was linked to changes in expression of genes related to nucleosomal regulation of transcription, T cell differentiation, and the inflammatory response and correlated with subject age, sex, and the presence of HCV-specific CD4+ T cell populations. These early changes in HCV-specific CD8+ T cell transcription preceded the overt establishment of T cell exhaustion, making this signature a prime target in the search for the regulatory origins of T cell dysfunction in chronic viral infection.
Copyright © 2017 Elsevier Inc. All rights reserved.
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Journal articles
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https://www.hal.inserm.fr/inserm-02315536
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Submitted on : Monday, October 14, 2019 - 3:18:39 PM
Last modification on : Thursday, February 25, 2021 - 6:52:01 PM
Contributor : Anne Daulny <>
Submitted on : Monday, October 14, 2019 - 3:18:39 PM
Last modification on : Thursday, February 25, 2021 - 6:52:01 PM
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Identifiers
- HAL Id : inserm-02315536, version 1
- PUBMEDCENTRAL : PMC5708133
- PUBMED : 29045899
- DOI : 10.1016/j.immuni.2017.09.006
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INSERM | SITE-ALSACE | U1110 | RIIP
Citation
David Wolski, Peter Foote, Diana Chen, Lia Lewis-Ximenez, Catherine Fauvelle, et al.. Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection. Immunity, Elsevier, 2017, 47 (4), pp.648-663.e8. ⟨10.1016/j.immuni.2017.09.006⟩. ⟨inserm-02315536⟩
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