Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Association between borderline dysnatremia and mortality insight into a new data mining approach

Abstract : BACKGROUND: Even small variations of serum sodium concentration may be associated with mortality. Our objective was to confirm the impact of borderline dysnatremia for patients admitted to hospital on in-hospital mortality using real life care data from our electronic health record (EHR) and a phenome-wide association analysis (PheWAS). METHODS: Retrospective observational study based on patient data admitted to Hôpital Européen George Pompidou, between 01/01/2008 and 31/06/2014; including 45,834 patients with serum sodium determinations on admission. We analyzed the association between dysnatremia and in-hospital mortality, using a multivariate logistic regression model to adjust for classical potential confounders. We performed a PheWAS to identify new potential confounders. RESULTS: Hyponatremia and hypernatremia were recorded for 12.0% and 1.0% of hospital stays, respectively. Adjusted odds ratios (ORa) for severe, moderate and borderline hyponatremia were 3.44 (95% CI, 2.41-4.86), 2.48 (95% CI, 1.96-3.13) and 1.98 (95% CI, 1.73-2.28), respectively. ORa for severe, moderate and borderline hypernatremia were 4.07 (95% CI, 2.92-5.62), 4.42 (95% CI, 2.04-9.20) and 3.72 (95% CI, 1.53-8.45), respectively. Borderline hyponatremia (ORa = 1.57 95% CI, 1.35-1.81) and borderline hypernatremia (ORa = 3.47 95% CI, 2.43-4.90) were still associated with in-hospital mortality after adjustment for classical and new confounding factors identified through the PheWAS analysis. CONCLUSION: Borderline dysnatremia on admission are independently associated with a higher risk of in-hospital mortality. By using medical data automatically collected in EHR and a new data mining approach, we identified new potential confounding factors that were highly associated with both mortality and dysnatremia.
Complete list of metadata

Cited literature [41 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02307293
Contributor : Myriam Bodescot Connect in order to contact the contributor
Submitted on : Monday, October 7, 2019 - 2:32:24 PM
Last modification on : Friday, December 3, 2021 - 11:43:08 AM

File

s12911-017-0549-7.pdf
Publication funded by an institution

Identifiers

Citation

yannick Girardeau, Anne-Sophie Jannot, Gilles Chatellier, Olivier Saint-Jean. Association between borderline dysnatremia and mortality insight into a new data mining approach. BMC Medical Informatics and Decision Making, BioMed Central, 2017, 17 (1), pp.152. ⟨10.1186/s12911-017-0549-7⟩. ⟨inserm-02307293⟩

Share

Metrics

Record views

34

Files downloads

46