Global cancer statistics, CA Cancer J Clin, vol.61, pp.69-90, 2011. ,
Latest research and treatment of advanced-stage epithelial ovarian cancer, Nat Rev Clin Oncol, vol.10, pp.211-224, 2013. ,
MicroRNAs in cancer, Annu Rev Pathol, vol.9, pp.287-314, 2014. ,
Causes and consequences of microRNA dysregulation, Cancer J, vol.18, pp.215-222, 2012. ,
The role of microRNAs in ovarian cancer, Biomed Res Int, p.249393, 2014. ,
Landscape of transcription in human cells, Nature, vol.489, pp.101-108, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01216755
The ENCODE project: missteps overshadowing a success, Curr.Biol, vol.23, pp.259-261, 2013. ,
Molecular mechanisms of long noncoding RNAs, Mol Cell, vol.43, pp.904-914, 2011. ,
The noncoding RNA revolutiontrashing old rules to forge new ones, Cell, vol.157, pp.77-94, 2014. ,
Long non-coding RNAs: insights into functions, Nat Rev Genet, vol.10, pp.155-159, 2009. ,
Epigenetic regulation by long noncoding RNAs, Science, vol.338, pp.1435-1439, 2012. ,
The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation, Mol Cell, vol.39, pp.925-938, 2010. ,
Emerging roles of competing endogenous RNAs in cancer: insights from the regulation of PTEN, Mol Cell Biol, vol.33, pp.3976-3982, 2013. ,
The multilayered complexity of ceRNA crosstalk and competition, Nature, vol.505, pp.344-352, 2014. ,
Identification of mammalian microRNA host genes and transcription units, Genome Res, vol.14, pp.1902-1910, 2004. ,
Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer, Carcinogenesis, vol.31, pp.350-358, 2010. ,
The emergence of lncRNAs in cancer biology, Cancer Discov, vol.1, pp.391-407, 2011. ,
Long noncoding RNAs and the genetics of cancer, Br J Cancer, vol.108, pp.2419-2425, 2013. ,
A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer, Cancer Cell, vol.26, pp.344-357, 2014. ,
,
, Genome-wide identification of polycomb-associated RNAs by RIP-seq, Mol Cell, vol.40, pp.939-953, 2010.
Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency, Elife, vol.3, p.2046, 2014. ,
Long noncoding RNAs: past, present, and future, Genetics, vol.193, pp.651-669, 2013. ,
Long noncoding RNA as modular scaffold of histone modification complexes, Science, vol.329, pp.689-693, 2010. ,
ATRX directs binding of PRC2 to Xist RNA and Polycomb targets, Cell, vol.159, pp.869-883, 2014. ,
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts, Nat. Rev.Mol.Cell Biol, vol.14, pp.699-712, 2013. ,
,
MEG3 long noncoding RNA regulates the TGF-beta pathway genes through formation of RNA-DNA triplex structures, Nat.Commun, vol.6, p.7743, 2015. ,
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs, Cell, vol.129, pp.1311-1323, 2007. ,
Perspectives on the mechanism of transcriptional regulation by long noncoding RNAs, Epigenetics, vol.9, pp.13-20, 2014. ,
The H19 locus: role of an imprinted non-coding RNA in growth and development, Bioessays, vol.32, pp.473-480, 2010. ,
H19 acts as a trans regulator of the imprinted gene network controlling growth in mice, Development, vol.136, pp.3413-3421, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02194081
Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression, Cancer Res, vol.71, pp.5365-5369, 2011. ,
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology, Nature, vol.465, pp.1033-1038, 2010. ,
Expanded identification and characterization of mammalian circular RNAs, Genome Biol, vol.15, p.409, 2014. ,
Competitive endogenous RNAs cannot alter microRNA function in vivo, Mol Cell, vol.54, pp.711-713, 2014. ,
LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b, Hum Mol Genet, vol.24, pp.841-852, 2015. ,
The imprinted H19 lncRNA antagonizes let-7 microRNAs, Mol Cell, vol.52, pp.101-112, 2013. ,
The complexity of miRNAmediated repression, Cell Death.Differ, vol.22, pp.22-33, 2015. ,
MicroRNAs: target recognition and regulatory functions, Cell, vol.136, pp.215-233, 2009. ,
Regulation of microRNA biogenesis, Nat.Rev.Mol.Cell Biol, vol.15, pp.509-524, 2014. ,
Genome-wide and species-wide in silico screening for intragenic MicroRNAs in human, mouse and chicken, PLoS.One, vol.8, p.65165, 2013. ,
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer, Nat Struct Mol Biol, vol.20, pp.908-913, 2013. ,
, Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma, Nature, vol.474, pp.609-615, 2011.
Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification, PLoS One, vol.8, p.80306, 2013. ,
An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles, Mol Cell, vol.33, pp.717-726, 2009. ,
Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma, BMC Cancer, vol.10, p.576, 2010. ,
Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells, Neoplasma, vol.62, pp.432-438, 2015. ,
Elevated expression of the serine-arginine protein kinase 1 gene in ovarian cancer and its role in Cisplatin cytotoxicity in vitro, PLoS.One, vol.7, p.51030, 2012. ,
Long, abundantly expressed non-coding transcripts are altered in cancer, www.impactjournals.com/oncotarget, vol.17, pp.1180-1189, 2008. ,
Malat1 regulates serum response factor through miR-133 as a competing endogenous RNA in myogenesis, FASEB J, vol.29, pp.3054-3064, 2015. ,
Growth of glioblastoma is inhibited by miR-133-mediated EGFR suppression, Tumour.Biol, vol.36, pp.9553-9561, 2015. ,
miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation, Cell Death.Dis, vol.5, p.1445, 2014. ,
ZNF300P1 encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer, Mol Cancer, vol.13, p.3, 2014. ,
A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancer, Oncotarget, vol.6, pp.25381-25389, 2015. ,
Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression, Oncogene, vol.22, pp.7225-7232, 2003. ,
LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation, RNA Biol, vol.8, pp.496-505, 2011. ,
Long noncoding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer, Medicine (Baltimore), vol.93, p.303, 2014. ,
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer, Clin Cancer Res, vol.13, pp.5745-5755, 2007. ,
PVT1 dependence in cancer with MYC copy-number increase, Nature, vol.512, pp.82-86, 2014. ,
The identification of microRNAs in a genomically unstable region of human chromosome 8q24, Mol Cancer Res, vol.6, pp.212-221, 2008. ,
Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1, Int.J Clin Exp.Pathol, vol.8, pp.3803-3810, 2015. ,
Role of p53 and Rb in ovarian cancer, Adv.Exp.Med.Biol, vol.622, pp.99-117, 2008. ,
Knockdown of long noncoding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152, Cancer Lett, vol.359, pp.75-86, 2015. ,
Xist RNA is a potent suppressor of hematologic cancer in mice, Cell, vol.152, pp.727-742, 2013. ,
Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells, Oncogene, vol.23, pp.6163-6169, 2004. ,
Relationship of XIST expression and responses of ovarian cancer to chemotherapy, Mol Cancer Ther, vol.1, pp.769-776, 2002. ,
Long noncoding RNA as modular scaffold of histone modification complexes, Science, vol.329, pp.689-693, 2010. ,
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis, Nature, vol.464, pp.1071-1076, 2010. ,
The hallmarks of cancer: a long non-coding RNA point of view, RNA Biol, vol.9, pp.703-719, 2012. ,
The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis, Exp.Cell Res, vol.333, pp.238-248, 2015. ,
HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer, Genome Med, vol.7, p.108, 2015. ,
Histones and their modifications in ovarian cancer -drivers of disease and therapeutic targets, Front Oncol, vol.4, p.144, 2014. ,
Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/beta-catenin pathway in human ovarian cancer, Tumour.Biol, 2015. ,
Overexpression of long noncoding RNA HOTAIR predicts poor patient prognosis and www.impactjournals.com/oncotarget promotes tumor metastasis in epithelial ovarian cancer, Gynecol Oncol, vol.134, pp.121-128, 2014. ,
Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute myeloid leukemia, FEBS Lett, vol.589, pp.1981-1987, 2015. ,
Gain-of-function microRNA screens identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells, Int.J Oncol, vol.42, pp.1875-1882, 2013. ,
Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract, Nat.Med, vol.11, pp.531-537, 2005. ,
A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer, Oncotarget, vol.6, pp.34745-57, 2015. ,
ANRIL: Molecular Mechanisms and Implications in Human Health, Int.J Mol.Sci, vol.14, pp.1278-1292, 2013. ,
noncoding RNA, is an unexpected major hotspot in GWAS, FASEB J, vol.25, pp.444-448, 2011. ,
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all, Nat.Rev. Mol.Cell Biol, vol.7, pp.667-677, 2006. ,
p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition, Neoplasia, vol.14, pp.1269-1277, 2012. ,
Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer, Int.J Oncol, vol.46, pp.2497-2505, 2015. ,
Minireview: epigenetic changes in ovarian cancer, Endocrinology, vol.150, pp.4003-4011, 2009. ,
MEG3 noncoding RNA: a tumor suppressor, J Mol Endocrinol, vol.48, pp.45-53, 2012. ,
Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer, Tumour Biol, vol.35, pp.1065-1073, 2014. ,
Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer, Tumour Biol, vol.36, pp.4851-4860, 2015. ,
Activation of p53 by MEG3 non-coding RNA, J Biol Chem, vol.282, pp.24731-24742, 2007. ,
Promoter hypermethylation influences the suppressive role of maternally expressed 3, a long non-coding RNA, in the development of epithelial ovarian cancer, Oncol Rep, vol.32, pp.277-285, 2014. ,
MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1, Med Oncol, vol.31, p.879, 2014. ,
The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2, Oncotarget, vol.6, pp.2397-2406, 2015. ,
Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma, Int J Cancer, vol.135, pp.2282-2293, 2014. ,
MiR-26a promotes ovarian cancer proliferation and tumorigenesis, PLoS.One, vol.9, p.86871, 2014. ,
Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression, J Exp.Clin Cancer Res, vol.34, p.79, 2015. ,
microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition, Nat. Commun, vol.5, p.2977, 2014. ,
Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression, Cancer Lett, vol.333, pp.213-221, 2013. ,
Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences, J Transl Med, vol.7, p.69, 2009. ,
Expression of the imprinted H19 oncofetal RNA in epithelial ovarian cancer, Eur J Obstet Gynecol Reprod Biol, vol.85, pp.7-11, 1999. ,
The H19 locus acts in vivo as a tumor suppressor, Proc Natl Acad Sci, vol.105, pp.12417-12422, 2008. ,
Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation, Oncogene, vol.34, pp.3076-84, 2015. ,
miR-675 mediates downregulation of Twist1 and Rb in AFP-secreting hepatocellular carcinoma, Ann Surg Oncol, vol.20, issue.3, pp.625-635, 2013. ,
Long non-coding RNA H19 promotes glioma cell invasion by deriving miR-675, PLoS One, vol.9, p.86295, 2014. ,
Oncofetal H19 RNA promotes tumor metastasis, Biochim Biophys Acta, vol.1843, pp.1414-1426, 2014. ,
Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer, Anticancer Res, vol.30, pp.1559-1564, 2010. ,
MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer, Cancer Res, vol.69, pp.9090-9095, 2009. ,
Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues, Exp Oncol, vol.30, pp.70-74, 2008. ,
Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer, PLoS One, vol.6, 2011. ,
EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients, Carcinogenesis, vol.31, pp.1576-1583, 2010. ,
,
, MicroRNA-101 inhibits growth of epithelial ovarian cancer by relieving chromatin-mediated transcriptional repression of p21(waf(1)/cip(1)), Pharm Res, vol.28, pp.3079-3090, 2011.
Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo, Cancer Biol Ther, vol.10, pp.788-795, 2010. ,
EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53, Cancer Lett, vol.336, pp.53-60, 2013. ,
MicroRNA expression profiles in serous ovarian carcinoma, Clin Cancer Res, vol.14, pp.2690-2695, 2008. ,
Let-7 expression defines two differentiation stages of cancer, Proc Natl Acad Sci, vol.104, pp.11400-11405, 2007. ,
MicroRNA expression and identification of putative miRNA targets in ovarian cancer, PLoS One, vol.3, p.2436, 2008. ,
MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer, Cancer Res, vol.68, pp.10307-10314, 2008. ,
Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis, Cancer Res, vol.67, pp.10117-10122, 2007. ,
Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin, Oncogenesis, vol.2, p.75, 2013. ,
Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM, PLoS One, vol.7, p.33729, 2012. ,
Meta-analysis of transcriptome reveals let-7b as an unfavorable prognostic biomarker and predicts molecular and clinical subclasses in high-grade serous ovarian carcinoma, Int J Cancer, vol.134, pp.306-318, 2014. ,
Prospective multicentre evaluation of PCA3 and TMPRSS2-ERG gene fusions as diagnostic and prognostic urinary biomarkers for prostate cancer, Eur Urol, vol.65, pp.534-542, 2014. ,
Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure, Circ.Res, vol.114, pp.1569-1575, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02267443
Role of EZH2 in Epithelial Ovarian Cancer: From Biological Insights to Therapeutic Target, Front Oncol, vol.3, p.47, 2013. ,
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations, Nature, vol.492, pp.108-112, 2012. ,
Targeting diphtheria toxin and TNF alpha expression in ovarian tumors using the H19 regulatory sequences, Int J Clin Exp Med, vol.3, pp.270-282, 2010. ,
Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report, J Med Case Rep, vol.4, p.228, 2010. ,