N. G. Bisset, One man's poison, another man's medicine?, J. Ethnopharmacol, vol.32, pp.71-81, 1991.

K. D. Rainsford, Ibuprofen: Pharmacology, efficacy and safety, Inflammopharmacology, vol.17, pp.275-342, 2009.

B. G. Livett, D. W. Sandall, D. Keays, J. Down, K. R. Gayler et al., Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor, Toxicon, vol.48, pp.810-829, 2006.

R. J. Lewis and M. L. Garcia, Therapeutic potential of venom peptides, Nat. Rev. Drug. Discov, vol.2, pp.790-802, 2003.

L. Brieger, Zur Kenntniss der Aetiologie des Wundstarrkrampfes nebst Bemerkungen über das Choleraroth, Dtsch. Med. Wochenschr, vol.1887, pp.303-305

I. Pastan, V. Chaudhary, and D. J. Fitzgerald, Recombinant toxins as novel therapeutic agents, Annu. Rev. Biochem, vol.61, pp.331-354, 1992.

J. P. Changeux and A. Taly, Nicotinic receptors, allosteric proteins and medicine, Trends. Mol. Med, vol.14, pp.93-102, 2008.

G. L. Collingridge, R. W. Olsen, J. Peters, and M. Spedding, A nomenclature for ligand-gated ion channels, Neuropharmacology, vol.56, pp.2-5, 2009.

A. Karlin, Emerging structure of the nicotinic acetylcholine receptors, Nat. Rev. Neurosci, vol.3, pp.102-114, 2002.

N. Le-novere, J. P. Changeux, and . Lgicdb, The ligand-gated ion channel database, Nucleic. Acids. Res, vol.29, pp.294-295, 2001.

J. E. Baenziger and P. J. Corringer, 3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels, Neuropharmacology, vol.60, pp.116-125, 2011.

S. F. Traynelis, L. P. Wollmuth, C. J. Mcbain, F. S. Menniti, K. M. Vance et al., Glutamate receptor ion channels: Structure, regulation, and function, Pharmacol. Rev, vol.62, pp.405-496, 2010.

C. Bernard, Leç ons sur les effets des substances toxiques et mé dicamenteuses, p.1857

L. Angenot, A. Denoel, and M. Goffart, Curare-like effect of African Strychnos: Strychnos usambarensis Gilg du Rwanda, J. Pharm. Belg, vol.25, pp.73-77, 1970.

N. G. Bisset, War and hunting poisons of the New World. Part 1. Notes on the early history of curare, J. Ethnopharmacol, vol.36, pp.1-26, 1992.

J. N. Langley, On nerve ending and on special excitable substances in cells, Proc. Roy. Soc. Ser. B, vol.78, pp.170-194, 1906.

J. Changeux and S. J. Edelstein, Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition, p.284, 2005.

J. P. Changeux, M. Kasai, M. Huchet, and J. C. Meunier, Extraction from electric tissue of gymnotus of a protein presenting several typical properties characteristic of the physiological receptor of acetylcholine, C. R. Acad. Sci. Hebd. Seances. Acad. Sci. D, vol.270, pp.2864-2867, 1970.

J. P. Changeux, T. R. Podleski, and L. Wofsy, Affinity labeling of the acetylcholine-receptor, Proc. Natl. Acad. Sci, vol.58, pp.2063-2070, 1967.

P. Favreau, F. Le-gall, E. Benoit, and J. Molgo, A review on conotoxins targeting ion channels and acetylcholine receptors of the vertebrate neuromuscular junction, Acta. Physiol. Pharmacol. Ther. Latinoam, vol.49, pp.257-267, 1999.

Z. Vogel, A. J. Sytkowski, and M. W. Nirenberg, Acetylcholine receptors of muscle grown in vitro, Proc. Natl. Acad. Sci, vol.69, pp.3180-3184, 1972.

C. E. Morris and J. B. Harrison, Central nervous system features of a nicotine-resistant insect, the tobacco hornworm Manduca sexta, Tissue Cell, vol.16, pp.601-612, 1984.

H. H. Dale, The action of certain esters and ethers of choline, and their relation to muscarine, J. Pharmacol. Exp. Ther, vol.6, pp.147-190, 1914.

M. Tomizawa and J. E. Casida, Molecular recognition of neonicotinoid insecticides: The determinants of life or death, Acc. Chem. Res, vol.42, pp.260-269, 2009.

G. Matolcsy, M. Ná-dasy, and V. Andriska, Pesticide Chemistry, p.808, 1988.

U. Maskos, B. E. Molles, S. Pons, M. Besson, B. P. Guiard et al., Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors, Nature, vol.436, pp.103-107, 2005.
URL : https://hal.archives-ouvertes.fr/pasteur-00162546

I. G. Marshall and A. L. Harvey, Selective neuromuscular blocking properties of alpha-conotoxins in vivo, Toxicon, vol.28, pp.231-234, 1990.

H. R. Arias and M. P. Blanton, Alpha-conotoxins, Int. J. Biochem. Cell Biol, vol.32, pp.1017-1028, 2000.

J. M. Mcintosh, A. D. Santos, and B. M. Olivera, Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes, Annu. Rev. Biochem, vol.68, pp.59-88, 1999.

M. Ellison, J. M. Mcintosh, and B. M. Olivera, Alpha-conotoxins ImI and ImII. Similar alpha. 7 nicotinic receptor antagonists act at different sites, J. Biol. Chem, vol.278, pp.757-764, 2003.

L. Azam, C. Dowell, M. Watkins, J. A. Stitzel, B. M. Olivera et al., Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors, J. Biol. Chem, vol.280, pp.80-87, 2005.

P. Favreau, I. Krimm, F. Le-gall, M. J. Bobenrieth, H. Lamthanh et al., Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors, Biochemistry, vol.38, pp.6317-6326, 1999.

L. Liu, G. Chew, E. Hawrot, C. Chi, and C. Wang, Two potent alpha3/5 conotoxins from piscivorous Conus achatinus, Acta Biochim. Biophys. Sin (Shanghai), vol.39, pp.438-444, 2007.

J. S. Martinez, B. M. Olivera, W. R. Gray, A. G. Craig, D. R. Groebe et al., alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity, Biochemistry, vol.34, pp.14519-14526, 1995.

R. C. Hogg, L. P. Miranda, D. J. Craik, R. J. Lewis, P. F. Alewood et al., Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor, J. Biol. Chem, vol.274, pp.36559-36564, 1999.

S. Luo, T. A. Nguyen, G. E. Cartier, B. M. Olivera, D. Yoshikami et al., Single-residue alteration in alpha-conotoxin PnIA switches its nAChR subtype selectivity, Biochemistry, vol.38, pp.14542-14548, 1999.

J. M. Mcintosh, C. Dowell, M. Watkins, J. E. Garrett, D. Yoshikami et al., Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors, J. Biol. Chem, vol.277, pp.33610-33615, 2002.

G. E. Cartier, D. Yoshikami, W. R. Gray, S. Luo, B. M. Olivera et al., A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors, J. Biol. Chem, vol.271, pp.7522-7528, 1996.

J. M. Mcintosh, L. Azam, S. Staheli, C. Dowell, J. M. Lindstrom et al., Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors, Mol. Pharmacol, vol.65, pp.944-952, 2004.

C. Dowell, B. M. Olivera, J. E. Garrett, S. T. Staheli, M. Watkins et al., Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors, J. Neurosci, vol.23, pp.8445-8452, 2003.

E. Lopez-vera, R. B. Jacobsen, M. Ellison, B. M. Olivera, and R. W. Teichert, A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors, Toxicon, vol.49, pp.1193-1199, 2007.

S. Dutertre, A. Nicke, and R. J. Lewis, Beta2 subunit contribution to. 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor, J. Biol. Chem, vol.280, pp.30460-30468, 2005.

A. Nicke, M. L. Loughnan, E. L. Millard, P. F. Alewood, D. J. Adams et al., Isolation, structure, and activity of GID, a novel alpha. 4/7-conotoxin with an extended N-terminal sequence, J. Biol. Chem, vol.278, pp.3137-3144, 2003.

A. Nicke, S. Wonnacott, and R. J. Lewis, Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes, Eur. J. Biochem, vol.271, pp.2305-2319, 2004.

M. Loughnan, T. Bond, A. Atkins, J. Cuevas, D. J. Adams et al., alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors, J. Biol. Chem, vol.273, pp.15667-15674, 1998.

R. W. Fitch, Y. Xiao, K. J. Kellar, and J. W. Daly, Membrane potential fluorescence: A rapid and highly sensitive assay for nicotinic receptor channel function, Proc. Natl. Acad. Sci, vol.100, pp.4909-4914, 2003.

V. N. Aiyar, M. H. Benn, T. Hanna, J. Jacyno, S. H. Roth et al., The principal toxin of Delphinium brownii Rydb., and its mode of action, Experientia, vol.35, pp.1367-1368, 1979.

D. R. Macallan, G. G. Lunt, S. Wonnacott, K. L. Swanson, H. Rapoport et al., Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems, FEBS Lett, vol.226, pp.357-363, 1988.

J. M. Ward, V. B. Cockcroft, G. G. Lunt, F. S. Smillie, S. Wonnacott et al., A selective probe for neuronal alpha-bungarotoxin binding sites, FEBS Lett, vol.270, pp.45-48, 1990.

C. F. Kukel and K. R. Jennings, Delphinium alkaloids as inhibitors of alpha-bungarotoxin binding to rat and insect neural membranes. Can, J. Physiol. Pharmacol, vol.72, pp.104-107, 1994.

P. Dobelis, J. E. Madl, J. A. Pfister, G. D. Manners, and J. P. Walrond, Effects of Delphinium alkaloids on neuromuscular transmission, J. Pharmacol. Exp. Ther, vol.291, pp.538-546, 1999.

J. A. Pfister, D. R. Gardner, K. E. Panter, G. D. Manners, M. H. Ralphs et al., Delphinium spp.) poisoning in livestock, J. Nat. Toxins, vol.8, pp.81-94, 1999.

K. Stromgaard, Natural products as tools for studies of ligand-gated ion channels, Chem. Rec, vol.5, pp.229-239, 2005.

K. M. Hold, N. S. Sirisoma, T. Ikeda, T. Narahashi, and J. E. Casida, Alpha-thujone (the active component of absinthe): Gamma-aminobutyric acid type A receptor modulation and metabolic detoxification, Proc. Natl. Acad. Sci, vol.97, pp.3826-3831, 2000.

T. Deiml, R. Haseneder, W. Zieglgansberger, G. Rammes, B. Eisensamer et al., Alpha-thujone reduces. 5-HT3 receptor activity by an effect on the agonist-reduced desensitization, Neuropharmacology, vol.46, pp.192-201, 2004.

H. K. Chen and C. K. Su, Endogenous activation of nicotinic receptors underlies sympathetic tone generation in neonatal rat spinal cord in vitro, Neuropharmacology, vol.51, pp.1120-1128, 2006.

B. E. Erkkila, A. V. Sedelnikova, and D. S. Weiss, Stoichiometric pore mutations of the GABAAR reveal a pattern of hydrogen bonding with picrotoxin, Biophys. J, vol.94, pp.4299-4306, 2008.

S. Charon, A. Taly, J. Rodrigo, P. Perret, and M. Goeldner, Binding Modes of Noncompetitive GABA-Channel Blockers Revisited Using Engineered Affinity-Labeling Reactions Combined with New Docking Studies (dagger), J. Agric. Food Chem, issue.10, 1021.

J. W. Johnson and P. Ascher, Glycine potentiates the NMDA response in cultured mouse brain neurons, Nature, vol.325, pp.529-531, 1987.

L. J. England, J. Imperial, R. Jacobsen, A. G. Craig, J. Gulyas et al., Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails, Science, vol.281, pp.575-578, 1998.

D. Yan and M. M. White, Interaction of d-tubocurarine analogs with mutant 5-HT(3) receptors, Neuropharmacology, vol.43, pp.367-373, 2002.

H. R. Griffith and G. Johnson, The use of curare in general anasthesia, Anesthesiology, vol.3, pp.418-420, 1942.

T. N. Parks, A. L. Mueller, L. D. Artman, B. C. Albensi, E. F. Nemeth et al., Arylamine toxins from funnel-web spider

C. Cohen, O. E. Bergis, F. Galli, A. W. Lochead, S. Jegham et al., Scatton, B. SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation, J. Pharmacol. Exp. Ther, vol.306, pp.407-420, 2003.

L. F. Martin, W. R. Kem, and R. Freedman, Alpha-7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia, Psychopharmacology (Berl), vol.174, pp.54-64, 2004.

S. Wei, L. Qiu, Z. H. Chen, and M. C. Xu, Effect observation of Snake venom point injection in the treatment of scapulohumeral periarthritis, Chin. J. Infor. Traditional Chin. Med, vol.14, pp.68-96, 2007.

A. Grozio, L. Paleari, A. Catassi, D. Servent, M. Cilli et al., Natural agents targeting the alpha7-nicotinic-receptor in NSCLC: A promising prospective in anti-cancer drug development, Int. J. Cancer, vol.122, pp.1911-1915, 2008.

E. R. Spindel, Is nicotine the estrogen of lung cancer?, Am. J. Respir. Crit. Care. Med, vol.179, pp.1081-1082, 2009.

L. Paleari, E. Negri, A. Catassi, M. Cilli, D. Servent et al., Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment, Am. J. Respir. Crit. Care. Med, vol.179, pp.1141-1150, 2009.

A. Catassi, L. Paleari, D. Servent, F. Sessa, L. Dominioni et al., Targeting alpha7-nicotinic receptor for the treatment of pleural mesothelioma, Eur. J. Cancer, vol.44, pp.2296-2311, 2008.

P. Russo, A. Catassi, A. Cesario, and D. Servent, Development of novel therapeutic strategies for lung cancer: Targeting the cholinergic system, Curr. Med. Chem, vol.13, pp.3493-3512, 2006.

Z. X. Chen, H. L. Zhang, Z. L. Gu, B. W. Chen, R. Han et al., A long-form alpha-neurotoxin from cobra venom produces potent opioid-independent analgesia, Acta Pharmacol. Sin, vol.27, pp.402-408, 2006.

P. F. Reid, Alpha-cobratoxin as a possible therapy for multiple sclerosis: A review of the literature leading to its development for this application, Crit. Rev. Immunol, vol.27, pp.291-302, 2007.

H. L. Zhang, R. Han, Z. X. Chen, Z. L. Gu, P. F. Reid et al., Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom, Neurosci. Bull, vol.22, pp.267-273, 2006.

S. T. Nevin, R. J. Clark, H. Klimis, M. J. Christie, D. J. Craik et al., Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?, Mol. Pharmacol, vol.72, pp.1406-1410, 2007.

B. Callaghan, A. Haythornthwaite, G. Berecki, R. J. Clark, D. J. Craik et al., Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation, J. Neurosci, vol.28, pp.10943-10951, 2008.

L. Azam and J. M. Mcintosh, Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors, Acta. Pharmacol. Sin, vol.30, pp.771-783, 2009.

Z. Tuba, S. Maho, and E. S. Vizi, Synthesis and structure-activity relationships of neuromuscular blocking agents, Curr. Med. Chem, vol.9, pp.1507-1536, 2002.

T. Hughes, The early history of myasthenia gravis, Neuromuscul. Disord, vol.15, pp.878-886, 2005.

A. Vincent, Unravelling the pathogenesis of myasthenia gravis, Nat. Rev. Immunol, vol.2, pp.797-804, 2002.

A. G. Engel and S. M. Sine, Current understanding of congenital myasthenic syndromes, Curr. Opin. Pharmacol, vol.5, pp.308-321, 2005.

J. Garcia-colunga and R. Miledi, Modulation of nicotinic acetylcholine receptors by strychnine, Proc. Natl. Acad. Sci, vol.96, pp.4113-4118, 1999.

A. S. Verkman and L. J. Galietta, Chloride channels as drug targets, Nat. Rev. Drug. Discov, vol.8, pp.153-171, 2009.

B. Laube, G. Maksay, R. Schemm, and H. Betz, Modulation of glycine receptor function: A novel approach for therapeutic intervention at inhibitory synapses?, Trends Pharmacol. Sci, vol.23, pp.519-527, 2002.

J. Walstab, G. Rappold, and B. Niesler, 5-HT(3) receptors: Role in disease and target of drugs, Pharmacol. Ther, vol.128, pp.146-169, 2010.

M. Koller and S. Urwyler, Novel N-methyl-D-aspartate receptor antagonists: A review of compounds patented since, Expert. Opin. Ther. Pat, vol.20, pp.1683-1702, 2006.

A. B. Malmberg, H. Gilbert, R. T. Mccabe, and A. I. Basbaum, Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T, vol.101, pp.109-116, 2003.

A. Hama and J. Sagen, Antinociceptive effects of the marine snail peptides conantokin-G and conotoxin MVIIA alone and in combination in rat models of pain, Neuropharmacology, vol.56, pp.556-563, 2009.

E. C. Jimenez, S. Donevan, C. Walker, L. M. Zhou, J. Nielsen et al., Conantokin-L, a new NMDA receptor antagonist: Determinants for anticonvulsant potency, Epilepsy Res, vol.51, pp.73-80, 2002.

M. Prorok and F. J. Castellino, The molecular basis of conantokin antagonism of NMDA receptor function, Curr. Drug. Targets, vol.8, pp.633-642, 2007.

G. T. Swanson and R. Sakai, Ligands for ionotropic glutamate receptors, Prog. Mol. SubCell Biol, vol.46, pp.123-157, 2009.

Z. Li, D. Liang, and L. Chen, Potential therapeutic targets for ATP-gated P2X receptor ion channels, Assay Drug. Dev. Technol, vol.6, pp.277-284, 2008.

H. Gunosewoyo and M. Kassiou, P2X purinergic receptor ligands: Recently patented compounds, Expert Opin. Ther. Pat, vol.20, pp.625-646, 2010.

T. J. Ryan and S. G. Grant, The origin and evolution of synapses, Nat. Rev. Neurosci, vol.10, pp.701-712, 2009.

A. Tasneem, L. M. Iyer, E. Jakobsson, and L. Aravind, Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels, Genome. Biol, vol.6, p.4, 2005.

N. Bocquet, L. Prado-de-carvalho, J. Cartaud, J. Neyton, C. Le-poupon et al., A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family, Nature, vol.445, pp.116-119, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00122527

G. Q. Chen, C. Cui, M. L. Mayer, and E. Gouaux, Functional characterization of a potassiumselective prokaryotic glutamate receptor, Nature, vol.402, pp.817-821, 1999.

R. H. Osborne, Insect neurotransmission: Neurotransmitters and their receptors, Pharmacol. Ther, vol.69, pp.117-142, 1996.

M. Ryten, R. Koshi, G. E. Knight, M. Turmaine, P. Dunn et al., Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor, Neuroscience, vol.148, pp.700-711, 2007.

D. J. Adams, P. F. Alewoodb, D. J. Craikb, R. D. Drinkwaterc, and R. J. , Lewis Conotoxins and Their Potential Pharmaceutical Applications, Drug Dev. Res, vol.46, pp.219-234, 1999.

L. Moise, A. Piserchio, V. J. Basus, and E. Hawrot, NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha. 7 subunit of a neuronal nicotinic acetylcholine receptor, J. Biol. Chem, vol.277, pp.12406-12417, 2002.

A. Samson, T. Scherf, M. Eisenstein, J. Chill, and J. Anglister, The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR, Neuron, vol.35, pp.319-332, 2002.

H. Osaka, S. Malany, B. E. Molles, S. M. Sine, and P. Taylor, Pairwise electrostatic interactions between alpha-neurotoxins and gamma, delta, and epsilon subunits of the nicotinic acetylcholine receptor, J. Biol. Chem, vol.275, pp.5478-5484, 2000.

D. Servent and A. Menez, Snake neurotoxins that interact with nicotinic acetylcholine receptors, Handbook of Neurotoxicology, pp.385-425, 2001.

H. Zeng and E. Hawrot, NMR-based binding screen and structural analysis of the complex formed between alpha-cobratoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica, J. Biol. Chem, vol.277, pp.37439-37445, 2002.

B. W. Low, H. S. Preston, A. Sato, L. S. Rosen, J. E. Searl et al., Three dimensional structure of erabutoxin b neurotoxic protein: Inhibitor of acetylcholine receptor, Proc. Natl. Acad. Sci, vol.73, pp.2991-2994, 1976.

J. M. Miwa, I. Ibanez-tallon, G. W. Crabtree, R. Sanchez, A. Sali et al., Heintz, N. lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS, Neuron, vol.23, pp.105-114, 1999.

E. N. Lyukmanova, Z. O. Shenkarev, M. A. Shulepko, K. S. Mineev, D. Hoedt et al., Nmr Structure and Action on Nicotinic Acetylcholine Receptors of Water-Soluble Domain of Human Lynx1, J. Biol. Chem, issue.10, 2011.

J. Pawlak, S. P. Mackessy, B. G. Fry, M. Bhatia, G. Mourier et al., Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity, J. Biol. Chem, vol.281, pp.29030-29041, 2006.

M. C. Tsai, W. H. Hsieh, L. A. Smith, and C. Y. Lee, Effects of waglerin-I on neuromuscular transmission of mouse nerve-muscle preparations, Toxicon, vol.33, pp.363-371, 1995.

Y. N. Utkin, V. V. Kukhtina, E. V. Kryukova, F. Chiodini, D. Bertrand et al., Weak toxin" from Naja kaouthia is a nontoxic antagonist of alpha. 7 and muscle-type nicotinic acetylcholine receptors, J. Biol. Chem, vol.276, pp.15810-15815, 2001.

S. Nirthanan, E. Charpantier, P. Gopalakrishnakone, M. C. Gwee, H. E. Khoo et al., Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta ) but a poorly reversible antagonist of neuronal alpha. 7 nicotinic acetylcholine receptors, J. Biol. Chem, vol.277, pp.17811-17820, 2002.

F. J. Joubert and N. Taljaard, Naja haje haje (Egyptian cobra) venom. Some properties and the complete primary structure of three toxins (CM-2, CM-11 and CM-12), Eur. J. Biochem, vol.90, pp.359-367, 1978.

A. L. Harvey, R. C. Hider, S. J. Hodges, and F. J. Joubert, Structure-activity studies of homologues of short chain neurotoxins from Elapid snake venoms, Br. J. Pharmacol, vol.82, pp.709-716, 1984.

F. H. Carlsson, Snake venom toxins. The primary structure of protein S4C11. A neurotoxin homologue from the venom of forest cobra (Naja melanoleuca), Biochim. Biophys. Acta, vol.400, pp.310-321, 1975.

F. J. Joubert and N. Taljaard, Some properties and the complete primary structures of two reduced and S-carboxymethylated polypeptides (S5C1 and S5C10) from Dendroaspis jamesoni kaimosae (Jameson's mamba) venom, Biochim. Biophys. Acta, vol.579, pp.228-233, 1979.

S. D. Aird, G. C. Womble, and J. R. Yates,

P. R. Griffin, Primary structure of gammabungarotoxin, a new postsynaptic neurotoxin from venom of Bungarus multicinctus, Toxicon, vol.37, pp.609-625, 1999.

S. L. Poh, G. Mourier, R. Thai, A. Armugam, J. Molgo et al., A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken alpha7 nicotinic acetylcholine receptors, Eur. J. Biochem, vol.269, pp.4247-4256, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00193986

L. Chang, S. Lin, J. Wang, W. P. Hu, B. Wu et al., Structure-function studies on Taiwan cobra long neurotoxin homolog, Biochim. Biophys. Acta, vol.1480, pp.293-301, 2000.

A. L. Harvey and I. W. Rodger, Reversibility of neuromuscular blockade produced by toxins isolated from the venom of the seasnake Laticauda semifasciata, Toxicon, vol.16, pp.219-225, 1978.

T. J. Brier, I. R. Mellor, D. B. Tikhonov, I. Neagoe, Z. Shao et al., Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors, Mol. Pharmacol, vol.64, pp.954-964, 2003.

Q. Shu and S. P. Liang, Purification and characterization of huwentoxin-II, a neurotoxic peptide from the venom of the Chinese bird spider Selenocosmia huwena, J. Pept. Res, vol.53, pp.486-491, 1999.

S. P. Liang, D. Y. Zhang, X. Pan, Q. Chen, and P. A. Zhou, Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena, Toxicon, vol.31, pp.969-978, 1993.

J. W. Daly, Nicotinic agonists, antagonists, and modulators from natural sources, Cell Mol. Neurobiol, vol.25, pp.513-552, 2005.

R. B. Barlow and L. J. Mcleod, Some studies on cytisine and its methylated derivatives, Br. J. Pharmacol, vol.35, pp.161-174, 1969.

J. Osswald, S. Rellan, A. Gago, and V. Vasconcelos, Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin-a, Environ. Int, vol.33, pp.1070-1089, 2007.

S. Merel, M. Clement, and O. Thomas, State of the art on cyanotoxins in water and their behaviour towards chlorine, Toxicon, vol.55, pp.677-691, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01122372

R. Araoz, N. Vilarino, L. M. Botana, and J. Molgo, Ligand-binding assays for cyanobacterial neurotoxins targeting cholinergic receptors, Anal. Bioanal. Chem, vol.397, pp.1695-1704, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00466393

B. Badio, J. W. Daly, and . Epibatidine, Mol. Pharmacol, vol.45, pp.563-569, 1994.

W. R. Kem, V. M. Mahnir, R. L. Papke, and C. J. Lingle, Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors, J. Pharmacol. Exp. Ther, vol.283, pp.979-992, 1997.

C. E. Spivak, M. A. Maleque, A. C. Oliveira, L. M. Masukawa, T. Tokuyama et al., Actions of the histrionicotoxins at the ion channel of the nicotinic acetylcholine receptor and at the voltage-sensitive ion channels of muscle membranes, Mol. Pharmacol, vol.21, pp.351-361, 1982.

R. C. Bick, J. W. Gillard, and H. Leow, Alkaloids of Darlingia ferruginea.Australian Australian, J. Chem, vol.32, pp.2537-2543, 1979.

E. F. Van-maanen, The antagonism between acetylcholine and the curare alkaloids, d-tubocurarine, c-curarine-I, c-toxiferine-II and beta-erythroidine in the rectus abdominis of the frog, J. Pharmacol. Exp. Ther, vol.99, pp.255-264, 1950.

A. A. Jensen, D. P. Zlotos, and T. Liljefors, Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor, J. Med. Chem, vol.50, pp.4616-4629, 2007.

G. Tay, Diallyl nor-Toxiferine -a New Relaxant, Singapore Med. J, vol.141, pp.90-92, 1963.

T. Kosuge, K. Tsuji, and K. Hirai, Isolation of neosurugatoxin from the Japanese ivory shell, Babylonia japonica, Chem. Pharm. Bull (Tokyo), vol.30, pp.3255-3259, 1982.

E. Hayashi, M. Isogai, Y. Kagawa, N. Takayanagi, and S. Yamada, Neosurugatoxin, a specific antagonist of nicotinic acetylcholine receptors, J. Neurochem, vol.42, pp.1491-1494, 1984.

E. Hayashi and S. Yamada, Pharmacological studies on surugatoxin, the toxic principle from Japanese ivory mollusc (Babylonia japonica), Br. J. Pharmacol, vol.53, pp.207-215, 1975.

C. Tornoe, D. Bai, L. Holden-dye, S. N. Abramson, and D. B. Sattelle, Actions of neurotoxins (bungarotoxins, neosurugatoxin and lophotoxins) on insect and nematode nicotinic acetylcholine receptors, Toxicon, vol.33, pp.411-424, 1995.

R. Maciulaitis, V. Kontrimaviciute, F. M. Bressolle, and V. Briedis, Ibogaine, an anti-addictive drug: Pharmacology and time to go further in development. A narrative review, Hum. Exp. Toxicol, vol.27, pp.181-194, 2008.

D. C. Mash, C. A. Kovera, B. E. Buck, M. D. Norenberg, P. Shapshak et al., Medication development of ibogaine as a pharmacotherapy for drug dependence, Ann. N. Y. Acad. Sci, vol.844, pp.274-292, 1998.

H. Matsubayashi, M. Alkondon, E. F. Pereira, K. L. Swanson, and E. X. Albuquerque, Strychnine: A potent competitive antagonist of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons, J. Pharmacol. Exp. Ther, vol.284, pp.904-913, 1998.

M. M. Francis, E. Y. Cheng, G. A. Weiland, and R. E. Oswald, Specific activation of the alpha. 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine, Mol. Pharmacol, vol.60, pp.71-79, 2001.

W. Haefely, The effects of various "nicotine-like" agents in the cat superior cervical ganglion in situ, Naunyn. Schmiedebergs. Arch. Pharmacol, vol.281, pp.93-117, 1974.

Y. Sakurai, Y. Takano, Y. Kohjimoto, K. Honda, and H. O. Kamiya, Enhancement of [3H]dopamine release and its [3H]metabolites in rat striatum by nicotinic drugs, Brain. Res, vol.242, pp.99-106, 1982.

K. B. Rozman, R. Araoz, K. Sepcic, J. Molgo, and D. Suput, Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine receptors, Chem. Biol. Interact, vol.187, pp.384-387, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00464523

P. Culver, M. Burch, C. Potenza, L. Wasserman, W. Fenical et al., Structure-activity relationships for the irreversible blockade of nicotinic receptor agonist sites by lophotoxin and congeneric diterpene lactones, Mol. Pharmacol, vol.28, pp.436-444, 1985.

P. Culver, W. Fenical, and P. Taylor, Lophotoxin irreversibly inactivates the nicotinic acetylcholine receptor by preferential association at one of the two primary agonist sites, J. Biol. Chem, vol.259, pp.3763-3770, 1984.

P. Culver, R. S. Jacobs, and . Lophotoxin, A neuromuscular acting toxin from the sea whip (Lophogorgia rigida), Toxicon, vol.19, pp.825-830, 1981.

W. Fenical, R. K. Okuda, M. M. Bandurraga, P. Culver, R. S. Jacobs et al., A novel neuromuscular toxin from Pacific sea whips of the genus Lophogorgia, Science, vol.212, pp.1512-1514, 1981.

C. W. Luetje, K. Wada, S. Rogers, S. N. Abramson, K. Tsuji et al., Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations, J. Neurochem, vol.55, pp.632-640, 1990.

S. N. Abramson, Y. Li, P. Culver, and P. Taylor, An analog of lophotoxin reacts covalently with Tyr190 in the alpha-subunit of the nicotinic acetylcholine receptor, J. Biol. Chem, vol.264, pp.12666-12672, 1989.

U. Holmskov, S. B. Laursen, R. Malhotra, H. Wiedemann, R. Timpl et al., Comparative study of the structural and functional properties of a bovine plasma C-type lectin, collectin-43, with other collectins, Biochem. J, vol.305, pp.889-896, 1995.

G. A. Johnston, J. R. Hanrahan, M. Chebib, R. K. Duke, and K. N. Mewett, Modulation of ionotropic GABA receptors by natural products of plant origin, Adv. Pharmacol, vol.54, pp.285-316, 2006.

T. Takemoto, T. Nakajima, and R. Sakuma, Isolation of a Flycidal Constituent "Ibotenic Acid" from Amanita Muscaria and A. Pantherina, Yakugaku. Zasshi, vol.84, pp.1233-1234, 1964.

T. Takemoto, T. Nakajima, and T. Yokobe, Structure of Ibotenic Acid, Yakugaku. Zasshi, vol.84, pp.1232-1233, 1964.

L. J. Casarett, J. Doull, C. D. Klaassen, and . Casarett, Doull's Toxicology: The Basic Science of Poisons

U. K. London, , p.1236, 2008.

K. Shin-ya, J. Kim, K. Furihata, Y. Hayakawa, and H. Seto, Structure of kaitocephalin, a novel glutamate receptor antagonist produced by Eupenicillium shearii, Tetrahedron. Lett, vol.36, pp.7079-7082, 1997.

A. Limon, J. M. Reyes-ruiz, R. G. Vaswani, A. R. Chamberlin, and R. Miledi, Kaitocephalin antagonism of glutamate receptors expressed in Xenopus oocytes, ACS. Chem. Neurosci, vol.1, pp.175-181, 2010.

H. J. Reis, M. A. Prado, E. Kalapothakis, M. N. Cordeiro, C. R. Diniz et al., Inhibition of glutamate uptake by a polypeptide toxin (phoneutriatoxin. 3-4) from the spider Phoneutria nigriventer, Biochem. J, vol.343, pp.413-418, 1999.

R. A. Mafra, S. G. Figueiredo, C. R. Diniz, M. N. Cordeiro, J. D. Cruz et al., PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes, Brain. Res, vol.831, pp.297-300, 1999.

S. G. De-figueiredo, M. E. De-lima, M. Nascimento-cordeiro, C. R. Diniz, D. Patten et al., Purification and amino acid sequence of a highly insecticidal toxin from the venom of the brazilian spider Phoneutria nigriventer which inhibits NMDA-evoked currents in rat hippocampal neurones, Toxicon, vol.39, pp.309-317, 2001.

T. Piek, Neurotoxins from venoms of the Hymenoptera--twenty-five years of research in Amsterdam, Comp. Biochem. Physiol. C, vol.96, pp.223-233, 1990.

R. B. Clark, P. L. Donaldson, K. A. Gration, J. J. Lambert, T. Piek et al., Block of locust muscle glutamate receptors by delta-philanthotoxin occurs after receptor activations, Brain. Res, issue.241, pp.105-114, 1982.

R. M. Hagan, B. J. Jones, C. C. Jordan, and M. B. Tyers, Effect of 5-HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat, Br. J. Pharmacol, vol.99, pp.227-232, 1990.

T. F. Andersen, D. B. Tikhonov, U. Bolcho, K. Bolshakov, J. K. Nelson et al., Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives, J. Med. Chem, vol.49, pp.5414-5423, 2006.

L. D. Rash and W. C. Hodgson, Pharmacology and biochemistry of spider venoms, Toxicon, vol.40, pp.225-254, 2002.

P. T. Brackley, D. R. Bell, S. K. Choi, K. Nakanishi, and P. N. Usherwood, Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins, J. Pharmacol. Exp. Ther, vol.266, pp.1573-1580, 1993.

T. Chiba, T. Akizawa, M. Matsukawa, H. Pan-hou, and M. Yoshioka, Finding of primitive polyamine toxins in the venom of a joro spider, Nephila clavata, Chem. Pharm. Bull (Tokyo), vol.42, pp.1864-1869, 1994.

L. S. Sorkin, T. L. Yaksh, and C. M. Doom, Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists, Anesthesiology, vol.95, pp.965-973, 2001.

R. Gmelin, Isolation of willardiin, a new plant amino acid which is probably L-beta-(3-uracil)-alpha-aminopropionic acid, Hoppe. Seylers. Z. Physiol. Chem, vol.316, pp.164-169, 1959.

R. H. Evans, A. W. Jones, and J. C. Watkins, Willardiine: A potent quisqualate-like excitant, J. Physiol, vol.308, pp.71-72, 1980.

H. Shinozaki and M. Ishida, Excitatory amino acids: Physiological and pharmacological probes for neuroscience research, Acta. Neurobiol. Exp (Wars), vol.53, pp.43-51, 1993.

A. C. Scallet and X. Ye, Excitotoxic mechanisms of neurodegeneration in transmissible spongiform encephalopathies, Ann. N Y. Acad. Sci, vol.825, pp.194-205, 1997.

B. B. Agrawal and I. J. Goldstein, Protein-carbohydrate interaction. VI. Isolation of concanavalin A by specific adsorption on cross-linked dextran gels, Biochim. Biophys. Acta, vol.147, pp.262-271, 1967.

D. Bowie, E. P. Garcia, J. Marshall, S. F. Traynelis, and G. D. Lange, Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins, J. Physiol, vol.547, pp.373-385, 2003.

L. M. Boland, J. A. Morrill, and B. P. Bean, omega-Conotoxin block of N-type calcium channels in frog and rat sympathetic neurons, J. Neurosci, vol.14, pp.5011-5027, 1994.

U. V. Lalo, Y. V. Pankratov, D. Arndts, and O. A. Krishtal, Omega-conotoxin GVIA potently inhibits the currents mediated by P2X receptors in rat DRG neurons, Brain. Res. Bull, vol.54, pp.507-512, 2001.

M. Skals, N. R. Jorgensen, J. Leipziger, and H. A. Praetorius, Alpha-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis, Proc. Natl. Acad. Sci, vol.106, pp.4030-4035, 2009.

O. Yilmaz, L. Yao, K. Maeda, T. M. Rose, E. L. Lewis et al., ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis, Cell Microbiol, vol.10, pp.863-875, 2008.

C. Csolle and B. Sperlagh, Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors, J. Neuroimmunol, vol.219, pp.38-46, 2010.

L. Verstrepen, T. Bekaert, T. L. Chau, J. Tavernier, A. Chariot et al., TLR-4, IL-1R and TNF-R signaling to NF-kappaB: Variations on a common theme, Cell Mol. Life. Sci, vol.65, pp.2964-2978, 2008.

D. J. Cameron, Inhibition of macrophage mediated cytotoxicity by exogenous adenosine. 5'-triphosphate, J. Clin. Lab. Immunol, vol.15, pp.215-218, 1984.

W. P. Schilling, T. Wasylyna, G. R. Dubyak, B. D. Humphreys, and . Sinkins, Maitotoxin and P2Z/P2X(7) purinergic receptor stimulation activate a common cytolytic pore, Am. J. Physiol, vol.277, pp.766-776, 1999.

P. M. Lundy, P. Nelson, L. Mi, R. Frew, S. Minaker et al., Pharmacological differentiation of the P2X7 receptor and the maitotoxin-activated cationic channel, Eur. J. Pharmacol, vol.487, pp.17-28, 2004.