From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

Abstract : Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
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Adak Nasiripourdori, Valérie Taly, Thomas Grutter, Antoine Taly. From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins, MDPI, 2011, 3 (3), pp.260-293. ⟨10.3390/toxins3030260⟩. ⟨inserm-02299586⟩

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