Acquisition of data (provided animals, acquired and managed patients, provided facilities, Taly Administrative, technical, or material support (i.e., reporting or organizing data, constructing databases): P. Laurent-Puig ,
Effect of low-frequency KRAS mutations on the response to anti-EGFR therapy in metastatic colorectal cancer, Ann Oncol, vol.24, pp.1267-73, 2013. ,
Global cancer statistics, CA Cancer J Clin, vol.61, pp.69-90, 2011. ,
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab, J Clin Oncol, vol.26, pp.374-383, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00363737
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab, J Clin Oncol, vol.25, pp.3230-3237, 2007. ,
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy, Br J Cancer, vol.96, pp.1166-1175, 2007. ,
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab, Ann Oncol, vol.19, pp.508-523, 2008. ,
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer, Lancet Oncol, vol.9, pp.962-72, 2008. ,
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer, J Clin Oncol, vol.27, pp.5924-5954, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00618089
Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations, Crit Rev Oncol Hematol, vol.85, pp.45-81, 2013. ,
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer, N Engl J Med, vol.369, pp.1023-1057, 2013. ,
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers, Nature, vol.486, pp.537-577, 2012. ,
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy, Int J Colorectal Dis, vol.26, pp.1271-1278, 2011. ,
KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program, Virchows Arch, vol.453, pp.417-448, 2008. ,
Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach, Pharmacogenomics, vol.11, pp.1169-79, 2010. ,
Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues, Anal Biochem, vol.391, pp.166-174, 2009. ,
Sensitive sequencing method for KRAS mutation detection by pyrosequencing, J Mol Diagn, vol.7, pp.413-434, 2005. ,
A commercial real-time PCR kit provides greater sensitivity than direct sequencing to detect KRAS mutations: a morphologybased approach in colorectal carcinoma, J Mol Diagn, vol.12, pp.292-301, 2010. ,
Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implications, J Mol Diagn, vol.12, pp.425-457, 2010. ,
Detecting biomarkers with microdroplet technology, Trends Mol Med, vol.18, pp.405-421, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-02299585
Quantitative and sensitive detection of rare mutations using droplet-based microfluidics, Lab Chip, pp.2156-66, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-02148770
Evaluation of a droplet digital polymerase chain reaction format for DNA copy number quantification, Anal Chem, vol.84, pp.1003-1014, 2012. ,
High-throughput droplet digital PCR system for absolute quantitation of DNA copy number, Anal Chem, vol.83, pp.8604-8614, 2011. ,
1-Million droplet array with wide-field fluorescence imaging for digital PCR, Lab Chip, vol.11, pp.3838-3883, 2011. ,
Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR, Lab Chip, vol.11, pp.2167-74, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02299588
Multiplex picoliter-droplet digital PCR for quantitative assessment of DNA integrity in clinical samples, Clin Chem, vol.59, pp.815-838, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-02299583
Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients, Clin Chem, vol.59, pp.1722-1753, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-02299581
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer, Nature, vol.486, pp.532-538, 2012. ,
Clinical relevance of kras mutation detection in metastatic colorectal cancer treated by cetuximala plus chemotherapy, Gastroenterology, vol.132, p.433, 2007. ,
Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer, Clin Cancer Res, vol.17, pp.4901-4915, 2011. ,
KRAS mutations detected by the amplification refractory mutation systemScorpion assays strongly correlate with therapeutic effect of cetuximab, Br J Cancer, vol.105, pp.403-409, 2011. ,
Detection and quantification of mutations in the plasma of patients with colorectal tumors, Proc Natl Acad Sci U S A, vol.102, pp.16368-73, 2005. ,
Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients, Gastroenterology, vol.135, pp.489-98, 2008. ,
Droplet Digital PCR quantitation of HER2 expression in FFPE breast cancer samples, Methods, vol.59, pp.20-23, 2013. ,
Digital quantification of mutant DNA in cancer patients, Curr Opin Oncol, vol.19, pp.36-42, 2007. ,
, Proc Natl Acad Sci U S A, vol.96, pp.9236-9277, 1999.
Liquid biopsy: monitoring cancer-genetics in the blood, Nat Rev Clin Oncol, vol.10, pp.472-84, 2013. ,
External quality assessment for KRAS testing is needed: setup of a European program and report of the first joined regional quality assessment rounds, Oncologist, vol.16, pp.467-78, 2011. ,
Molecular analysis of tumors to improve characterization and treatment, Clin Cancer Res, vol.21, pp.1087-1097, 2013. ,