J. Ferlay, I. Soerjomataram, and R. Dikshit, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int J Cancer, vol.136, pp.359-86, 2015.

V. Deschoolmeester, M. Baay, P. Specenier, F. Lardon, and J. B. Vermorken, A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy, Oncologist, vol.15, pp.699-731, 2010.

A. Custodio and J. Feliu, Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations, Crit Rev Oncol Hematol, vol.85, pp.45-81, 2013.

M. R. Sharma, M. L. Maitland, and M. J. Ratain, RECIST: no longer the sharpest tool in the oncology clinical trials toolbox-point, Cancer Res, vol.72, pp.5145-5154, 2012.

M. J. Goldstein and E. P. Mitchell, Carcinoembryonic antigen in the staging and followup of patients with colorectal cancer, Cancer Invest, vol.23, pp.338-51, 2005.

E. Kidess-sigal, H. E. Liu, and M. M. Triboulet, Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: comparison to ctDNA and tissue in metastatic colorectal cancer, Oncotarget, vol.7, pp.85349-64, 2016.

R. Lebofsky, C. Decraene, and V. Bernard, Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types, Mol Oncol, vol.9, pp.783-90, 2015.

F. Diehl, K. Schmidt, and M. A. Choti, Circulating mutant DNA to assess tumor dynamics, Nat Med, vol.14, pp.985-90, 2008.

F. Mouliere, S. El-messaoudi, D. Pang, A. Dritschilo, and A. R. Thierry, Multi-marker analysis of circulating cell-free DNA toward personalized medicine for colorectal cancer, Mol Oncol, vol.8, pp.927-968, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-01076572

K. L. Spindler, N. Pallisgaard, I. Vogelius, and A. Jakobsen, Quantitative cell-free DNA, KRAS, and BRAF mutations in plasma from patients with metastatic colorectal cancer during treatment with cetuximab and irinotecan, Clin Cancer Res, vol.18, pp.1177-85, 2012.

B. Lefebure, F. Charbonnier, D. Fiore, and F. , Prognostic value of circulating mutant DNA in unresectable metastatic colorectal cancer, Ann Surg, vol.251, pp.275-80, 2010.

M. Li, W. D. Chen, and N. Papadopoulos, Sensitive digital quantification of DNA methylation in clinical samples, Nat Biotechnol, vol.27, pp.858-63, 2009.

J. P. Roperch, R. Incitti, and S. Forbin, Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer, BMC Cancer, vol.13, p.566, 2013.

S. Garrigou, G. Perkins, and F. Garlan, A study of hypermethylated circulating tumor DNA as a universal colorectal cancer biomarker, Clin Chem, vol.62, pp.1129-1168, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02295782

M. Beyens, N. Boeckx, G. Van-camp, O. De-beeck, K. Vandeweyer et al., pyAmpli: an amplicon-based variant filter pipeline for targeted resequencing data, BMC Bioinformatics, vol.18, p.554, 2017.

M. Ma, H. Zhu, C. Zhang, X. Sun, X. Gao et al., Liquid biopsy"ectDNA detection with great potential and challenges, Ann Transl Med, vol.3, p.235, 2015.

J. Gao, B. A. Aksoy, and U. Dogrusoz, Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal, Sci Signal, vol.6, p.1, 2013.

E. Cerami, J. Gao, and U. Dogrusoz, The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data, Cancer Discov, vol.2, pp.401-405, 2012.

A. W. Berger, D. Schwerdel, and H. Welz, Treatment monitoring in metastatic colorectal cancer patients by quantification and KRAS genotyping of circulating cell-free DNA, PLoS One, vol.12, p.174308, 2017.

C. Bettegowda, M. Sausen, and R. J. Leary, Detection of circulating tumor DNA in early-and late-stage human malignancies, Sci Transl Med, vol.6, pp.224-248, 2014.

G. Siravegna, B. Mussolin, and M. Buscarino, Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients, Nat Med, vol.21, p.827, 2015.

J. Tie, I. Kinde, and Y. Wang, Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer, Ann Oncol, vol.26, pp.1715-1737, 2015.

J. Tabernero, H. J. Lenz, and S. Siena, Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial, Lancet Oncol, vol.16, pp.937-985, 2015.

S. J. Dawson, D. W. Tsui, and M. Murtaza, Analysis of circulating tumor DNA to monitor metastatic breast cancer, N Engl J Med, vol.368, pp.1199-209, 2013.

F. Garlan, P. Laurent-puig, and D. Sefrioui, Early evaluation of circulating tumor DNA as marker of therapeutic efficacy in metastatic colorectal cancer patients (PLACOL study), Clin Cancer Res, vol.23, pp.5416-5441, 2017.

A. Herbst, N. Vdovin, and S. Gacesa, Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer, Int J Cancer, vol.140, pp.2134-2178, 2017.

L. Barault, A. Amatu, and G. Siravegna, Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

F. C. Wong, K. Sun, and P. Jiang, Cell-free DNA in maternal plasma and serum: a comparison of quantity, quality and tissue origin using genomic and epigenomic approaches, Clin Biochem, vol.49, pp.1379-86, 2016.

O. Gautschi, C. Bigosch, and B. Huegli, Circulating deoxyribonucleic acid as prognostic marker in non-small-cell lung cancer patients undergoing chemotherapy, J Clin Oncol, vol.22, pp.4157-64, 2004.

R. E. Board, V. S. Williams, and L. Knight, Isolation and extraction of circulating tumor DNA from patients with small cell lung cancer, Ann N Y Acad Sci, vol.1137, pp.98-107, 2008.

V. Taly, D. Pekin, and L. Benhaim, Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients, Clin Chem, vol.59, pp.1722-1753, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-02299581