Role for Egr1 in the transcriptional program associated with neuronal differentiation of PC12 cells, PLoS ONE, vol.12, p.170076, 2017. ,
Mouse and rat BDNF gene structure and expression revisited, J Neurosci Res, vol.85, pp.525-535, 2007. ,
Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct, 2011. ,
, Immunoprecipitation with an anti-GR antibody followed by western blot analysis with an anti-EGR1 antibody (IP GR WB EGR1). MW: molecular weight markers in kDa, Input, non-immunoprecipitated cell lysate, GR and BDNF functionally interact in BZ cells. (A)
DEX RU). (B) PMA treatment rapidly increases Egr1 transcript expression as measured by RT-qPCR. Results are expressed as attomol Egr1/attomol 36b4; t0: before treatment ,
, IP experiment with an anti-GR antibody followed by Western blot analysis with anti-GR antibody. MW: molecular weight markers in kDa. Input, non-immunoprecipitated cell lysate, PMA 10 À8 M, IP is a mix of leftover from IP in D, all 4 conditions. (D) Upper panel, coImmunoprecipitation with anti-GR antibody followed by western blot analysis with anti-EGR1 antibody
Lower panel, quantification of band intensities by densitometry, a.u: arbitrary units. Left panel, Input samples, right panel IP samples. dendritic compartments, Proc Natl Acad Sci, vol.108, pp.16813-16818 ,
cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression, J Neurosci, vol.31, pp.18237-18250, 2011. ,
Sadenosylmethionine reduces the inhibitory effect of Ab on BDNF expression through decreasing methylation level of BDNF exon ? in rats, Biochem Biophys Res Commun, vol.495, pp.2609-2615, 2018. ,
Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuronlike cells, Mol Brain, vol.10, p.12, 2017. ,
Early life stress effects on glucocorticoid-bdnf interplay in the hippocampus, Front Mol Neurosci, vol.8, p.68, 2015. ,
The role of early growth response 1 (EGR1) in brain plasticity and neuropsychiatric disorders, Front Behav Neurosci, vol.11, p.35, 2017. ,
Stress and glucocorticoid receptordependent mechanisms in long-term memory: from adaptive responses to psychopathologies, Neurobiol Learn Mem, vol.112, pp.17-29, 2014. ,
Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade, Philos Trans R Soc Lond, B, Biol Sci, vol.367, pp.2495-2510, 2012. ,
Extraocular motor system exhibits a higher expression of neurotrophins when compared with other brainstem motor systems, Front Neurosci, vol.11, p.399, 2017. ,
Are BDNF and glucocorticoid activities calibrated?, Neuroscience, vol.239, pp.173-195, 2013. ,
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect, Proc Natl Acad Sci, vol.105, pp.4862-4867, 2008. ,
Role of BDNF epigenetics in activity-dependent neuronal plasticity, Neuropharmacology, vol.76, pp.709-718, 2014. ,
Brain-derived neurotrophic factor and major depressive disorder: evidence from meta-analyses, Front Psychiatry, vol.8, p.308, 2017. ,
A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?, Prog Neurobiol, vol.74, pp.183-211, 2004. ,
Update of neurotrophic factors in neurobiology of addiction and future directions, Neurobiol Dis, vol.97, pp.189-200, 2017. ,
BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity, Cell Mol Neurobiol, vol.38, pp.579-593, 2018. ,
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation, Mol Cell Biol, vol.33, pp.3700-3714, 2013. ,
Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells, FASEB J, vol.29, pp.3977-3989, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-01158040
Lombe`s M (2000) Targeted oncogenesis reveals a distinct tissuespecific utilization of alternative promoters of the human mineralocorticoid receptor gene in transgenic mice, J Biol Chem, vol.275, pp.7878-7886 ,
BDNF and hippocampal synaptic plasticity, Vitam Horm, vol.104, pp.153-195, 2017. ,
Molecular cloning and expression of brain-derived neurotrophic factor, Nature, vol.341, pp.149-152, 1989. ,
Maternal care, hippocampal glucocorticoid receptors, and hypothalamicpituitary-adrenal responses to stress, Science, vol.277, pp.1659-1662, 1997. ,
Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate, Am J Physiol Gastrointest Liver Physiol, vol.289, pp.653-663, 2005. ,
Immediate early genes anchor a biological pathway of proteins required for memory formation, long-term depression and risk for schizophrenia, Front Behav Neurosci, vol.12, p.23, 2018. ,
Bdnf mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus, Brain Struct Funct, vol.222, pp.3295-3307, 2017. ,
Brain-derived neurotrophic factor and glucocorticoids: reciprocal influence on the central nervous system, Neuroscience, vol.239, pp.157-172, 2013. ,
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease, J Allergy Clin Immunol, vol.132, pp.1033-1044, 2013. ,
Design of a novel gene therapy construct to achieve sustained brain-derived neurotrophic factor signaling in neurons, Hum Gene Ther, vol.29, pp.828-841, 2018. ,
Steroid receptor interactions with heat shock protein and immunophilin chaperones, Endocr Rev, vol.18, pp.306-360, 1997. ,
Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene, J Neurosci, vol.31, pp.3295-3308, 2011. ,
Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions, J Neurosci, vol.25, pp.6243-6250, 2005. ,
Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus, Neuroscience, vol.260, pp.265-275, 2014. ,
Lack of promoter IV-driven BDNF transcription results in depression-like behavior, Genes Brain Behav, vol.9, pp.712-721, 2010. ,
Huntington's disease: from mutant Huntingtin protein to neurotrophic factor therapy, Int J Biomed Sci, vol.7, pp.89-100, 2011. ,
AP-1 transcription factors mediate BDNF-positive feedback loop in cortical neurons, J Neurosci, vol.36, pp.1290-1305, 2016. ,
NeuroD factors discriminate mineralocorticoid from glucocorticoid receptor DNA binding in the male rat brain, Endocrinology, vol.158, pp.1511-1522, 2017. ,
The transcription factor Zif268/Egr1, brain plasticity, and memory, Prog Mol Biol Transl Sci, vol.122, pp.89-129, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01102902
Crosstalk between activated forms of the aryl hydrocarbon receptor and glucocorticoid receptor, Toxicology, vol.262, pp.87-97, 2009. ,
The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor, Philos Trans R Soc Lond, B, Biol Sci, p.369, 2014. ,
Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: recent developments, Brain Res, vol.1665, pp.1-21, 2017. ,
Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss, J Neurosci, vol.32, pp.8545-8553, 2012. ,