G. Ruiz-irastorza, M. Crowther, W. Branch, and M. A. Khamashta, Antiphospholipid syndrome, Lancet, vol.376, pp.1498-509, 2010.

G. R. Hughes, Hughes syndrome (the antiphospholipid syndrome): ten clinical lessons, Autoimmun Rev, vol.7, pp.262-268, 2008.

C. Christodoulou, S. Sangle, D. Cruz, and D. P. , Vasculopathy and arterial stenotic lesions in the antiphospholipid syndrome, Rheumatology (Oxford), vol.46, pp.907-917, 2007.

R. Cervera, M. A. Khamashta, Y. Shoenfeld, M. T. Camps, S. Jacobsen et al., Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients, Ann Rheum Dis, vol.68, pp.1428-1460, 2009.

M. Charakida, C. Besler, J. R. Batuca, S. Sangle, S. Marques et al., Vascular abnormalities, paraoxonase activity, and dysfunctional HDL in primary antiphospholipid syndrome, JAMA, vol.302, pp.1210-1217, 2009.

P. R. Ames, A. Margarita, and J. D. Alves, Antiphospholipid antibodies and atherosclerosis: insights from systemic lupus erythematosus and primary antiphospholipid syndrome, Clin Rev Allergy Immunol, vol.37, pp.29-35, 2009.

C. C. Belizna, V. Richard, E. Primard, J. M. Kerleau, N. Cailleux et al., Early atheroma in primary and secondary antiphospholipid syndrome: an intrinsic finding, Semin Arthritis Rheum, vol.37, pp.373-80, 2008.

M. Cugno, M. O. Borghi, L. M. Lonati, L. Ghiadoni, M. Gerosa et al., Patients with antiphospholipid syndrome display endothelial perturbation, J Autoimmun, vol.34, pp.105-115, 2010.

S. S. Pierangeli, M. Colden-stanfield, X. Liu, J. H. Barker, G. L. Anderson et al., Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo, Circulation, vol.99, pp.1997-2002, 1999.

M. Sorice, A. Longo, A. Capozzi, T. Garofalo, R. Misasi et al., Anti-?2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor ? and tissue factor by signal transduction pathways involving lipid rafts, Arthritis Rheum, vol.56, pp.2687-97, 2007.

S. Simoncini, C. Sapet, L. Camoin-jau, N. Bardin, J. R. Harle et al., Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome, Int Immunol, vol.17, pp.489-500, 2005.

S. K. Drexler and B. M. Foxwell, The role of Toll-like receptors in chronic inflammation, Int J Biochem Cell Biol, vol.42, pp.506-524, 2010.

Y. Benhamou, J. Favre, P. Musette, S. Renet, C. Thuillez et al., Toll-like receptors 4 contribute to endothelial injury and inflammation in hemorrhagic shock in mice, Crit Care Med, vol.37, pp.1724-1732, 2009.

J. Favre, P. Musette, V. Douin-echinard, K. Laude, J. P. Henry et al., Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction, Arterioscler Thromb Vasc Biol, vol.27, pp.1064-71, 2007.

H. M. Paterson, T. J. Murphy, E. J. Purcell, O. Shelley, S. J. Kriynovich et al., Injury primes the innate immune system for enhanced Toll-like receptor reactivity, J Immunol, vol.171, pp.1473-83, 2003.

K. L. Allen, F. V. Fonseca, V. Betapudi, B. Willard, J. Zhang et al., A novel pathway for human endothelial cell activation by antiphospholipid/anti-?2 glycoprotein I antibodies, Blood, vol.119, pp.884-93, 2011.

N. Satta, E. K. Kruithof, C. Fickentscher, S. Dunoyer-geindre, F. Boehlen et al., Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies, Blood, vol.117, pp.5523-5554, 2011.

H. Xie, H. Zhou, H. Wang, D. Chen, L. Xia et al., Anti-?2GPI/?2GPI induced TF and TNF-? expression in monocytes involving both TLR-4/MyD88 and TLR-4/TRIF signaling pathways, Mol Immunol, vol.53, pp.246-54, 2013.

E. Raschi, C. Testoni, D. Bosisio, M. O. Borghi, T. Koike et al., Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies, Blood, vol.101, pp.3495-500, 2003.

S. S. Pierangeli, M. E. Vega-ostertag, E. Raschi, X. Liu, Z. Romaypenabad et al., Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies, Ann Rheum Dis, vol.66, pp.1327-1360, 2007.

R. Joannides, C. Monteil, B. H. De-ligny, P. F. Westeel, M. Iacob et al., Immunosuppressant regimen based on sirolimus decreases aortic stiffness in renal transplant recipients in comparison to cyclosporine, Am J Transplant, vol.11, pp.2414-2436, 2011.

D. Maltete, J. Bellien, L. Cabrejo, M. Iacob, F. Proust et al., Hypertrophic remodeling and increased arterial stiffness in patients with intracranial aneurysms, Atherosclerosis, vol.211, pp.486-91, 2012.

J. Bellien, M. Iacob, R. , I. Lucas, D. Monteil et al., Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension, Circulation, vol.125, pp.1266-75, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00680446

M. R. Dasu, S. Devaraj, S. Park, and I. Jialal, Increased Toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects, Diabetes Care, vol.33, pp.861-869, 2010.

S. Banquet, E. Gomez, L. Nicol, F. Edwards-levy, J. P. Henry et al., Arteriogenic therapy by intramyocardial sustained delivery of a novel growth factor combination prevents chronic heart failure, Circulation, vol.124, pp.1059-69, 2011.

O. Benveniste, L. Drouot, F. Jouen, J. L. Charuel, C. Bloch-queyrat et al., Correlation of anti-signal recognition particle autoantibody levels with creatine kinase activity in patients with necrotizing myopathy, Arthritis Rheum, vol.63, pp.1961-71, 2011.

C. Belizna, A. Lartigue, J. Favre, D. Gilbert, F. Tron et al., Antiphospholipid antibodies induce vascular functional changes in mice: a mechanism of vascular lesions in antiphospholipid syndrome?, Lupus, vol.17, pp.185-94, 2008.

V. Pengo, G. Ruiz-irastorza, G. Denas, L. Andreoli, M. Khamashta et al., High intensity anticoagulation in the prevention of the recurrence of arterial thrombosis in antiphospholipid syndrome: 'PROS' and 'CONS, Autoimmun Rev, vol.11, pp.577-80, 2012.

F. Mercanoglu, D. Erdogan, H. Oflaz, R. Kucukkaya, F. Selcukbiricik et al., Impaired brachial endothelial function in patients with primary anti-phospholipid syndrome, Int J Clin Pract, vol.58, pp.1003-1010, 2004.

P. Gresele, R. Migliacci, M. C. Vedovati, A. Ruffatti, C. Becattini et al., Patients with primary antiphospholipid antibody syndrome and without associated vascular risk factors present a normal endothelial function, Thromb Res, vol.123, pp.444-51, 2009.

R. R. Forastiero, M. E. Martinuzzo, and G. F. De-larranaga, Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies, Lupus, vol.14, pp.129-165, 2005.

J. Swadzba, T. Iwaniec, and J. Musial, Increased level of tumor necrosis factor-? in patients with antiphospholipid syndrome: marker not only of inflammation but also of the prothrombotic state, Rheumatol Int, vol.31, pp.307-320, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00568320

H. Zhou, A. S. Wolberg, and R. A. Roubey, Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep, Blood, vol.104, pp.2353-2361, 2004.

D. Ferro, M. Saliola, P. L. Meroni, G. Valesini, C. Caroselli et al., Enhanced monocyte expression of tissue factor by oxidative ROLE OF

, stress in patients with antiphospholipid antibodies: effect of antioxidant treatment, J Thromb Haemost, vol.1, pp.523-554, 2003.

P. R. Ames, J. Nourooz-zadeh, C. Tommasino, J. Alves, V. Brancaccio et al., Oxidative stress in primary antiphospholipid syndrome, Thromb Haemost, vol.79, pp.447-456, 1998.

J. Delgado-alves, L. J. Mason, P. R. Ames, P. P. Chen, J. Rauch et al., Antiphospholipid antibodies are associated with enhanced oxidative stress, decreased plasma nitric oxide and paraoxonase activity in an experimental mouse model, Rheumatology (Oxford), vol.44, pp.1238-1282, 2005.

S. Ramesh, C. N. Morrell, C. Tarango, G. D. Thomas, I. S. Yuhanna et al., Antiphospholipid antibodies promote leukocyteendothelial cell adhesion and thrombosis in mice by antagonizing eNOS via ?2GPI and apoER2, J Clin Invest, vol.121, pp.120-151, 2011.

P. R. Ames, J. R. Batuca, A. Ciampa, L. Iannaccone, D. Alves et al., Clinical relevance of nitric oxide metabolites and nitrative stress in thrombotic primary antiphospholipid syndrome, J Rheumatol, vol.37, pp.2523-2553, 2010.

C. F. Liang, J. T. Liu, Y. Wang, A. Xu, and P. M. Vanhoutte, Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4, Arterioscler Thromb Vasc Biol, vol.33, pp.777-84, 2013.

G. Montiel-manzano, Z. Romay-penabad, P. De-martinez, E. Meillon-garcia, L. A. Garcia-latorre et al., In vivo effects of an inhibitor of nuclear factor-B on thrombogenic properties of antiphospholipid antibodies, Ann N Y Acad Sci, vol.1108, pp.540-53, 2007.

J. Zhang and K. R. Mccrae, Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-?2 glycoprotein I antibodies, Blood, vol.105, pp.1964-1973, 2005.

H. Zhou, D. Chen, H. Xie, L. Xia, T. Wang et al., Activation of MAPKs in the anti-?2GPI/?2GPI-induced tissue factor expression through TLR-4/IRAKs pathway in THP-1 cells, Thromb Res, vol.130, pp.229-264, 2012.

E. Charrier, P. Cordeiro, M. Cordeau, R. Dardari, A. Michaud et al., Post-transcriptional down-regulation of Toll-like receptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells, Cell Immunol, vol.276, pp.114-135, 2012.

K. D. Taganov, M. P. Boldin, K. J. Chang, and D. Baltimore, NF-Bdependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses, Proc Natl Acad Sci, vol.103, pp.12481-12487, 2006.

J. Fan, R. S. Frey, and A. B. Malik, TLR-4 signaling induces TLR-2 expression in endothelial cells via neutrophil NADPH oxidase, J Clin Invest, vol.112, pp.1234-1277, 2003.

N. Laflamme, H. Echchannaoui, R. Landmann, and S. Rivest, Cooperation between Toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gramnegative and gram-positive bacteria, Eur J Immunol, vol.33, pp.1127-1165, 2003.

G. Gladigau, P. Haselmayer, I. Scharrer, M. Munder, N. Prinz et al., A role for Toll-like receptor mediated signals in neutrophils in the pathogenesis of the anti-phospholipid syndrome, PLoS One, vol.7, p.42176, 2012.

A. Arad, V. Proulle, R. A. Furie, B. C. Furie, and B. Furie, ?2-glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model, Blood, vol.117, pp.3453-3462, 2011.

Y. Shoenfeld, M. Blank, R. Cervera, J. Font, E. Raschi et al., Infectious origin of the antiphospholipid syndrome, Ann Rheum Dis, vol.65, pp.2-6, 2006.

H. Xie, L. Sheng, H. Zhou, and J. Yan, The role of TLR-4 in pathophysiology of antiphospholipid syndrome-associated thrombosis and pregnancy morbidity, Br J Haematol, vol.164, pp.165-76, 2014.