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Journal articles
Cardiac lymphatics in health and disease
Abstract : The lymphatic vasculature, which accompanies the blood vasculature in most organs, is indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and nutritional lipid uptake and transport, as well as in reverse cholesterol transport. In this Review, we discuss the physiological role of the lymphatic system in the heart in the maintenance of cardiac health and describe alterations in lymphatic structure and function that occur in cardiovascular pathology, including atherosclerosis and myocardial infarction. We also briefly discuss the role that immune cells might have in the regulation of lymphatic growth (lymphangiogenesis) and function. Finally, we provide examples of how the cardiac lymphatics can be targeted therapeutically to restore lymphatic drainage in the heart to limit myocardial oedema and chronic inflammation.
Cited literature [171 references]
https://www.hal.inserm.fr/inserm-02296547
Contributor : Ebba Brakenhielm <>
Submitted on : Wednesday, September 25, 2019 - 11:57:46 AM
Last modification on : Tuesday, July 20, 2021 - 2:22:02 PM
Long-term archiving on: : Sunday, February 9, 2020 - 8:32:57 PM
Contributor : Ebba Brakenhielm <>
Submitted on : Wednesday, September 25, 2019 - 11:57:46 AM
Last modification on : Tuesday, July 20, 2021 - 2:22:02 PM
Long-term archiving on: : Sunday, February 9, 2020 - 8:32:57 PM