V. Irish, R. Lehmann, and M. Akam, The Drosophila posterior-group gene nanos functions by repressing hunchback activity, Nature, vol.338, issue.6217, pp.646-654, 1989.

C. Wang and R. Lehmann, Nanos is the localized posterior determinant in Drosophila, Cell, vol.66, issue.4, pp.637-684, 1991.

Z. Wang and H. Lin, Nanos maintains germline stem cell self-renewal by preventing differentiation, Science, vol.303, issue.5666, pp.2016-2025, 2004.

B. Ye, C. Petritsch, I. E. Clark, E. R. Gavis, L. Y. Jan et al., Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons, Curr Biol, vol.14, issue.4, pp.314-335, 2004.

C. J. Mee, E. C. Pym, K. G. Moffat, and R. A. Baines, Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene, J Neurosci, vol.24, issue.40, pp.8695-703, 2004.

N. I. Muraro, A. J. Weston, A. P. Gerber, S. Luschnig, K. G. Moffat et al., Pumilio binds Para mRNA and requires Nanos and brat to regulate sodium current in Drosophila motoneurons, J Neurosci, vol.28, issue.9, pp.2099-109, 2008.

H. Tan and W. W. Tee, Committing the primordial germ cell: an updated molecular perspective, Wiley Interdiscip Rev Syst Biol Med, vol.11, issue.1, p.1436, 2019.

M. Tsuda, Y. Sasaoka, M. Kiso, K. Abe, S. Haraguchi et al., Conserved role of nanos proteins in germ cell development, Science, vol.301, issue.5637, pp.1239-1280, 2003.

A. Suzuki, M. Tsuda, and Y. Saga, Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development, Development, vol.134, issue.1, pp.77-83, 2007.

K. Kusz-zamelczyk, M. Sajek, A. Spik, R. Glazar, P. Jedrzejczak et al., Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia, J Med Genet, vol.50, issue.3, pp.187-93, 2013.

V. T. Julaton, R. Pera, and R. A. , NANOS3 function in human germ cell development, Hum Mol Genet, vol.20, issue.11, pp.2238-50, 2011.

E. De-keuckelaere, P. Hulpiau, Y. Saeys, G. Berx, and F. Van-roy, Nanos genes and their role in development and beyond, Cell Mol Life Sci, vol.75, issue.11, pp.1929-1975, 2018.

F. Lai and M. L. King, Repressive translational control in germ cells, Mol Reprod Dev, vol.80, issue.8, pp.665-76, 2013.

T. Quenault, T. Lithgow, and A. Traven, PUF proteins: repression, activation and mRNA localization, Trends Cell Biol, vol.21, issue.2, pp.104-116, 2011.

M. Wang, L. Oge, M. D. Perez-garcia, L. Hamama, and S. Sakr, The PUF protein family: overview on PUF RNA targets, biological functions, and posttranscriptional regulation, Int J Mol Sci, vol.19, issue.2, 2018.

D. Bhandari, T. Raisch, O. Weichenrieder, J. S. Izaurralde, and E. , Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression, Genes Dev, vol.28, issue.8, pp.888-901, 2014.

R. Suzuki, S. Honda, and Y. Kirino, PIWI expression and function in cancer, Front Genet, vol.3, p.204, 2012.

V. K. Mayya and T. F. Duchaine, Ciphers and executioners: how 3?-untranslated regions determine the fate of messenger RNAs, Front Genet, vol.10, p.6, 2019.

J. Jaruzelska, M. Kotecki, K. Kusz, A. Spik, M. Firpo et al., Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells, Dev Genes Evol, vol.213, issue.3, pp.120-126, 2003.

C. A. Weidmann, C. Qiu, R. M. Arvola, T. F. Lou, J. Killingsworth et al., Drosophila Nanos acts as a molecular clamp that modulates the RNAbinding and repression activities of Pumilio, Elife, vol.5, 2016.

W. O. Miles, K. Tschop, A. Herr, J. Y. Ji, and N. J. Dyson, Pumilio facilitates miRNA regulation of the E2F3 oncogene, Genes Dev, vol.26, issue.4, pp.356-68, 2012.

A. Janic, L. Mendizabal, S. Llamazares, D. Rossell, and C. Gonzalez, Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila, Science, vol.330, issue.6012, pp.1824-1831, 2010.

K. Strumane, A. Bonnomet, C. Stove, R. Vandenbroucke, B. Nawrocki-raby et al., E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion, Cancer Res, vol.66, issue.20, pp.10007-10022, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00144608

A. Bonnomet, M. Polette, K. Strumane, C. Gilles, V. Dalstein et al., The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression, Oncogene, vol.27, issue.26, pp.3692-3701, 2008.

A. D. Krentz, M. W. Murphy, T. Zhang, A. L. Sarver, S. Jain et al., Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line, Dev Biol, vol.377, issue.1, pp.67-78, 2013.

A. Jorgensen, J. E. Nielsen, K. Almstrup, B. G. Toft, B. L. Petersen et al., Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ, J Pathol, vol.229, issue.4, pp.588-98, 2013.

S. Grelet, V. Andries, M. Polette, C. Gilles, K. Staes et al., The human NANOS3 gene contributes to lung tumour invasion by inducing epithelialmesenchymal transition, J Pathol, vol.237, issue.1, pp.25-37, 2015.

O. Nyabi, M. Naessens, K. Haigh, A. Gembarska, S. Goossens et al., Efficient mouse transgenesis using gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells, Nucleic Acids Res, vol.37, issue.7, p.55, 2009.

C. Postic, M. Shiota, K. D. Niswender, T. L. Jetton, Y. Chen et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase, J Biol Chem, vol.274, issue.1, pp.305-320, 1999.

A. Ramirez, A. Page, A. Gandarillas, J. Zanet, S. Pibre et al., A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cremediated recombination, Genesis, vol.39, issue.1, pp.52-59, 2004.
URL : https://hal.archives-ouvertes.fr/hal-02262417

A. K. Perl, S. E. Wert, D. E. Loudy, Z. Shan, P. A. Blair et al., Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli, Am J Respir Cell Mol Biol, vol.33, issue.5, pp.455-62, 2005.

S. Marino, M. Vooijs, H. Van-der-gulden, J. Jonkers, and A. Berns, Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum, Genes Dev, vol.14, issue.8, pp.994-1004, 2000.

D. A. Tuveson, A. T. Shaw, N. A. Willis, D. P. Silver, J. E. Chang et al., Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects, Cancer Cell, vol.5, issue.4, pp.375-87, 2004.

C. Kilkenny, W. J. Browne, I. C. Cuthill, M. Emerson, and D. G. Altman, Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research, PLoS Biol, vol.8, issue.6, p.1000412, 2010.

J. Vandesompele, D. Preter, K. Pattyn, F. Poppe, B. Van-roy et al., Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol, vol.3, issue.7, p.34, 2002.

R. W. Payne, D. A. Murray, S. A. Harding, D. B. Baird, and D. M. Soutar, An introduction to GenStat for windows. 14th ed. Hemel Hempstead. UK: VSN International, 2011.

S. Hayashi, P. Lewis, L. Pevny, and A. P. Mcmahon, Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain, Mech Dev, vol.119, issue.1, pp.97-101, 2002.

M. Gossen, S. Freundlieb, G. Bender, G. Muller, W. Hillen et al., Transcriptional activation by tetracyclines in mammalian cells, Science, vol.268, issue.5218, pp.1766-1775, 1995.

L. Johnson, K. Mercer, D. Greenbaum, R. T. Bronson, D. Crowley et al., Somatic activation of the K-ras oncogene causes early onset lung cancer in mice, Nature, vol.410, issue.6832, pp.1111-1117, 2001.

G. H. Fisher, S. L. Wellen, D. Klimstra, J. M. Lenczowski, J. W. Tichelaar et al., Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes, Genes Dev, vol.15, issue.24, pp.3249-62, 2001.

E. L. Jackson, K. P. Olive, D. A. Tuveson, R. Bronson, D. Crowley et al., The differential effects of mutant p53 alleles on advanced murine lung cancer, Cancer Res, vol.65, issue.22, pp.10280-10288, 2005.

G. Prelich, Gene overexpression: uses, mechanisms, and interpretation, Genetics, vol.190, issue.3, pp.841-54, 2012.

W. D. Travis, E. Brambilla, M. Noguchi, A. G. Nicholson, K. Geisinger et al., European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary, Proc Am Thorac Soc, vol.8, issue.5, pp.381-386, 2011.

D. H. Tompkins, V. Besnard, A. W. Lange, S. E. Wert, A. R. Keiser et al., Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells, PLoS One, vol.4, issue.12, p.8248, 2009.

K. D. Pruitt, J. Harrow, R. A. Harte, C. Wallin, M. Diekhans et al., The consensus coding sequence (CCDS) project: identifying a common proteincoding gene set for the human and mouse genomes, Genome Res, vol.19, issue.7, pp.1316-1339, 2009.

M. C. Kwon and A. Berns, Mouse models for lung cancer, Mol Oncol, vol.7, issue.2, pp.165-77, 2013.

C. Sheridan and J. Downward, Overview of KRAS-driven genetically engineered mouse models of non-small cell lung cancer, Curr Protoc Pharmacol, vol.70, pp.14-35, 2015.

S. Zheng, A. K. El-naggar, E. S. Kim, J. M. Kurie, and G. Lozano, A genetic mouse model for metastatic lung cancer with gender differences in survival, Oncogene, vol.26, issue.48, pp.6896-904, 2007.

P. M. Bracci, J. Sison, H. Hansen, K. M. Walsh, C. P. Quesenberry et al., Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS), J Thorac Oncol, vol.7, issue.9, pp.1352-60, 2012.

S. Sun, J. H. Schiller, and A. F. Gazdar, Lung cancer in never smokers--a different disease, Nat Rev Cancer, vol.7, issue.10, pp.778-90, 2007.

H. I. Kim, H. Lim, and A. Moon, Sex differences in cancer: epidemiology, genetics and therapy, Biomol Ther, vol.26, issue.4, pp.335-377, 2018.

X. Xu, L. Huang, C. Futtner, B. Schwab, R. R. Rampersad et al., The cell of origin and subtype of K-Ras-induced lung tumors are modified by notch and Sox2, Genes Dev, vol.28, issue.17, pp.1929-1968, 2014.

R. L. Perlman, Mouse models of human disease: an evolutionary perspective, Evol Med Public Health, vol.2016, issue.1, pp.170-176, 2016.

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