G. Airagnes, A. Pelissolo, M. Lavallee, M. Flament, and F. Limosin, Benzodiazepine misuse in the elderly: risk factors, consequences, and management, Curr Psychiatry Rep, vol.18, issue.10, p.89, 2016.

N. Ait-daoud, D. Blevins, S. Khanna, S. Sharma, and C. P. Holstege, Women and addiction, Psychiatr Clin N Am, vol.40, issue.2, pp.285-97, 2017.

, AFSSAPS: Etat des lieux de la consommation de benzodiazépines en France. Rapport d'expertise, 2012.

J. Brett and B. Murnion, Management of benzodiazepine misuse and dependence, Aust Prescr, vol.38, issue.5, pp.152-157, 2015.

J. Jankovic, Treatment of dystonia, Lancet Neurol, vol.5, issue.10, pp.864-72, 2006.

J. Donoghue and M. Lader, Usage of benzodiazepines: a review, Int J Psychiatry Clin Pract, vol.14, issue.2, pp.78-87, 2010.

M. Lader, Benzodiazepine harm: how can it be reduced?, Br J Clin Pharmacol, vol.77, issue.2, pp.295-301, 2014.

T. Nordfjaern, A population-based cohort study of anxiety, depression, sleep and alcohol outcomes among benzodiazepine and z-hypnotic users, Addict Behav, vol.37, issue.10, pp.1151-1158, 2012.

T. A. Kurko, L. K. Saastamoinen, S. Tahkapaa, A. Tuulio-henriksson, T. Taiminen et al., Long-term use of benzodiazepines: definitions, prevalence and usage patterns -a systematic review of registerbased studies, Eur Psychiatry, vol.30, issue.8, pp.1037-1084, 2015.

J. Micallef, E. Frauger, and M. Lapeyre-mestre, Chapter 102 -misuse of benzodiazepines in France A2 -Preedy, victor R. In: Neuropathology of Drug Addictions and Substance Misuse, pp.1101-1112, 2016.

L. Orriols, L. R. Salmi, P. Philip, N. Moore, B. Delorme et al., The impact of medicinal drugs on traffic safety: a systematic review of epidemiological studies, Pharmacoepidemiol Drug Saf, vol.18, issue.8, pp.647-58, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00370537

A. Konopka, J. Pe?ka-wysiecka, A. Grzywacz, and J. Samochowiec, Psychosocial characteristics of benzodiazepine addicts compared to not addicted benzodiazepine users, Prog Neuro-Psychopharmacol Biol Psychiatry, vol.40, pp.229-264, 2013.

V. Tapiainen, H. Taipale, A. Tanskanen, J. Tiihonen, S. Hartikainen et al., The risk of Alzheimer's disease associated with benzodiazepines and related drugs: a nested case-control study, Acta Psychiatr Scand, vol.138, issue.2, pp.91-100, 2018.

V. Kapil, J. Green, L. Lait, C. Wood, D. Dargan et al., Misuse of benzodiazepines and Z-drugs in the UK, Br J Psychiatry, vol.205, issue.5, pp.407-415, 2014.

L. Manthey, T. Van-veen, E. J. Giltay, J. E. Stoop, A. K. Neven et al., Correlates of (inappropriate) benzodiazepine use: the Netherlands study of depression and anxiety (NESDA), Br J Clin Pharmacol, vol.71, issue.2, pp.263-72, 2011.

G. B. Ten-wolde, A. Dijkstra, P. Van-empelen, K. Neven, A. Zitman et al., Psychological determinants of the intention to educate patients about benzodiazepines, Pharm World Sci, vol.30, issue.4, pp.336-378, 2008.

B. Glintborg, L. Olsen, H. Poulsen, K. Linnet, and K. Dalhoff, Reliability of selfreported use of amphetamine, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates among acutely hospitalized elderly medical patients, Clin toxicol, vol.46, issue.3, pp.239-281, 2008.

U. Busto, K. Lanctot, P. Isaac, and A. M. , Benzodiazepine use and abuse in Canada, CMAJ, vol.141, issue.9, p.917, 1989.

D. P. Jutte, L. L. Roos, and M. D. Brownell, Administrative record linkage as a tool for public Health Research, Annu Rev Public Health, vol.32, issue.1, pp.91-108, 2011.

K. Demyttenaere, A. Bonnewyn, R. Bruffaerts, D. Girolamo, G. Gasquet et al., Clinical factors influencing the prescription of antidepressants and benzodiazepines:: results from the European study of the epidemiology of mental disorders (ESEMeD), J Affect Disord, vol.110, issue.1, pp.84-93, 2008.

J. Van-der-heyden, L. Gisle, E. Hesse, S. Demarest, S. Drieskens et al., Gender differences in the use of anxiolytics and antidepressants: a population based study, Pharmacoepidemiol Drug Saf, vol.18, issue.11, pp.1101-1111, 2009.

I. Fride-tvete, T. Bjørner, and T. Skomedal, Risk factors for excessive benzodiazepine use in a working age population: a nationwide 5-year survey in Norway, Scand J Prim Health Care, vol.33, issue.4, pp.252-261, 2015.

B. Redonnet, A. Chollet, E. Fombonne, L. Bowes, and M. Melchior, Tobacco, alcohol, cannabis and other illegal drug use among young adults: the socioeconomic context, Drug Alcohol Depend, vol.121, issue.3, pp.231-240, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00679745

F. Lugoboni, A. Mirijello, M. Faccini, R. Casari, A. Cossari et al., Quality of life in a cohort of high-dose benzodiazepine dependent patients, Drug Alcohol Depend, vol.142, pp.105-114, 2014.

E. Holm, E. Fosbol, H. Pedersen, T. B. Jensen, M. Nielsen et al., Eur Geriatr Med, vol.3, issue.5, pp.299-303, 1997.

A. Morel, M. Grall-bronnec, S. Bulteau, P. Chauvin-grelier, L. Gailledrat et al., Benzodiazepine dependence in subjects with alcohol use disorders: what prevalence?, Expert Opin Drug Saf, vol.15, issue.10, pp.1313-1322, 2016.

M. Zins and M. Goldberg, The French CONSTANCES population-based cohort: design, inclusion and follow-up, Eur J Epidemiol, vol.30, issue.12, pp.1317-1345, 2015.

G. Santin, A. Guéguen, M. Carton, D. Cyr, and M. Genreau, Estimation de prévalences dans Constances : premières explorations, Bull Epidémiol Hebd, vol.35, issue.36, pp.622-631, 2016.

J. Bezin, M. Duong, R. Lassalle, C. Droz, A. Pariente et al., The national healthcare system claims databases in France, SNIIRAM and EGB: powerful tools for pharmacoepidemiology, Pharmacoepidemiol Drug Saf, vol.26, issue.8, pp.954-62, 2017.

J. M. Cloos, V. Bocquet, I. Rolland-portal, P. Koch, and G. Chouinard, Hypnotics and Triazolobenzodiazepines -best predictors of high-dose benzodiazepine use: results from the Luxembourg National Health Insurance Registry, Psychother Psychosom, vol.84, issue.5, pp.273-83, 2015.

G. Airagnes, C. Lemogne, R. Olekhnovitch, Y. Roquelaure, N. Hoertel et al., Work-related stressors and increased risk of benzodiazepine long-term use: findings from the CONSTANCES populationbased cohort, Am J Public Health, vol.0, issue.0, pp.1-7
URL : https://hal.archives-ouvertes.fr/hal-01978480

S. L. Schneider, The International Standard Classification of Education, Class and Stratification Analysis, vol.30, pp.365-379, 2011.

A. J. Morin, G. Moullec, C. Maiano, L. Layet, J. L. Just et al., Psychometric properties of the Center for Epidemiologic Studies Depression Scale (CES-D) in French clinical and nonclinical adults. Revue d'epidemiologie et de sante publique, vol.59, pp.327-367, 2011.

T. F. Babor, J. C. Higgins-biddle, J. B. Saunders, and M. G. Monteiro, AUDIT: the alcohol use disorders identification test: guidelines for use in primary health care, 2 edn. Geneva: World Health Organization, 2001.

C. D. Newgard and J. S. Haukoos, Advanced statistics: missing data in clinical research--part 2: multiple imputation, Acad Emerg Med Off J Soc Acad Emerg Med, vol.14, issue.7, pp.669-78, 2007.

P. Boudes, Drug compliance in therapeutic trials: a review, Control Clin Trials, vol.19, issue.3, pp.257-68, 1998.

, Les chiffres clés de la Sécurité sociale (édition 2016) www.securite-sociale.fr/ IMG/pdf/chiffres_cles_ed_2016_web, 2016.

C. C. Kan, M. H. Breteler, and F. G. Zitman, High prevalence of benzodiazepine dependence in out-patient users, based on the DSM-III-R and ICD-10 criteria, Acta Psychiatr Scand, vol.96, issue.2, pp.85-93, 1997.

C. I. Neutel and W. Walop, Drug utilization by men and women: why the differences?, Drug Inf J, vol.39, issue.3, pp.299-310, 2005.

C. Kan, S. Hilberink, and M. Breteler, Determination of the Main Risk Factors for Benzodiazepine Dependence Using a Multivariate and Multidimensional Approach, vol.45, 2004.

T. B. Ngoundo-mbongue, M. Niezborala, P. Sulem, D. Briant-vincens, Y. Bancarel et al., Psychoactive drug consumption: performance-enhancing behaviour and pharmacodependence in workers, Pharmacoepidemiol Drug Saf, vol.14, issue.2, pp.81-90, 2005.

M. Valenstein, K. K. Taylor, K. Austin, H. C. Kales, J. F. Mccarthy et al., Benzodiazepine use among depressed patients treated in mental health settings, Am J Psychiatr, vol.161, issue.4, pp.654-61, 2004.

, ANSM: Point d'information. Plan d'actions de l'ANSM visant à réduire le mésusage des benzodiazépines, 2012.

, HAS: Modalités d'arrêt des benzodiazépines et médicaments apparentés chez le patient âgé, 2007.

, HAS: Arrêt des benzodiazépines et médicaments apparentés: démarche du médecin traitant en ambulatoire, 2015.

A. Panes, R. Lassalle, M. Bernard, C. Dureaud-pournin, and A. Pariente, FourrierRéglat A. Misuse of benzodiazepines in the French population: a cohort study in the Échantillon Genéraliste de Bénéficiaires between 2007 and 2012. Revue d'epidemiologie et de sante publique, vol.64, pp.132-135, 2016.

M. Soyka, Treatment of benzodiazepine dependence, N Engl J Med, vol.376, issue.12, pp.1147-57, 2017.