DIABRISK-SL trial: further consideration of age and impact of imputations

Abstract : Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality worldwide. Early interventions may help to delay or prevent onset of cardiometabolic endpoints of clinical importance to T2DM patients.Wijesuriya et al. (BMC Med 15:146, 2017) published results of a randomised controlled trial in Sri Lanka testing the effect of two lifestyle modification programmes of varying intensity in participants aged 5-40 years with risk factors for T2DM. The intervention measured the impact of the two programmes on the primary composite endpoint consisting of various predictors of cardiometabolic disease. The authors concluded that the more intensive programme significantly reduced the incidence of predictors of cardiometabolic disease. Further, they delivered a large-scale intervention with restricted resources with widespread acceptance as demonstrated by the high uptake rate. However, we believe that further analysis is required to fully understand the potential for benefit, particularly in relation to age, retention and missing data.
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Efstathia Gkioni, Ketevan Glonti, Susanna Dodd, Carrol Gamble. DIABRISK-SL trial: further consideration of age and impact of imputations. BMC Medicine, BioMed Central, 2019, 17 (1), pp.121. ⟨10.1186/s12916-019-1361-2⟩. ⟨inserm-02291075⟩

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